Lysosomal enzyme cathepsin B enhances the aggregate forming activity of exogenous α-synuclein fibrils
The formation of intracellular aggregates containing α-synuclein (α-Syn) is one of the key steps in the progression of Parkinson's disease and dementia with Lewy bodies. Recently, it was reported that pathological α-Syn fibrils can undergo cell-to-cell transmission and form Lewy body-like aggre...
Main Authors: | Atsushi Tsujimura, Katsutoshi Taguchi, Yoshihisa Watanabe, Harutsugu Tatebe, Takahiko Tokuda, Toshiki Mizuno, Masaki Tanaka |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2015-01-01
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Series: | Neurobiology of Disease |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S0969996114003040 |
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