Tackling the Complexity of the Exposome: Considerations from the Gunma University Initiative for Advanced Research (GIAR) Exposome Symposium
The attempt to describe complex diseases by solely genetic determination has not been successful. There is increasing recognition that the development of disease is often a consequence of interactions between multiple genetic and environmental factors. To date, much of the research on environmental...
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doaj-13213780fb2e4371a655182ca4b2e0c22020-11-25T00:16:48ZengMDPI AGMetabolites2218-19892019-06-019610610.3390/metabo9060106metabo9060106Tackling the Complexity of the Exposome: Considerations from the Gunma University Initiative for Advanced Research (GIAR) Exposome SymposiumPei Zhang0Manish Arora1Romanas Chaleckis2Tomohiko Isobe3Mohit Jain4Isabel Meister5Erik Melén6Matthew Perzanowski7Federico Torta8Markus R. Wenk9Craig E. Wheelock10Gunma University Initiative for Advanced Research (GIAR), Gunma University, Maebashi 371-8510, JapanSenator Frank R Lautenberg Environmental Health Sciences Laboratory, Department of Environmental Medicine and Public Health, Division of Environmental Health, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USAGunma University Initiative for Advanced Research (GIAR), Gunma University, Maebashi 371-8510, JapanNational Center for the Japan Environment and Children’s Study, National Institute for Environmental Sciences, Tsukuba 305-0053, JapanDepartment of Medicine, University of California, San Diego, La Jolla, CA 92093, USAGunma University Initiative for Advanced Research (GIAR), Gunma University, Maebashi 371-8510, JapanInstitute of Environmental Medicine, Karolinska Institutet, Solna 171 77, SwedenDepartment of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY 10027, USADepartment of Biochemistry, YLL School of Medicine, National University of Singapore, Singapore 117597, SingaporeDepartment of Biochemistry, YLL School of Medicine, National University of Singapore, Singapore 117597, SingaporeGunma University Initiative for Advanced Research (GIAR), Gunma University, Maebashi 371-8510, JapanThe attempt to describe complex diseases by solely genetic determination has not been successful. There is increasing recognition that the development of disease is often a consequence of interactions between multiple genetic and environmental factors. To date, much of the research on environmental determinants of disease has focused on single exposures generally measured at a single time point. In order to address this limitation, the concept of the exposome has been introduced as a comprehensive approach, studying the full complement of environmental exposures from conception onwards. However, exposures are vast, dynamic, and diverse, and only a small proportion can be reasonably measured due to limitations in technology and feasibility. In addition, the interplay between genes and exposure as well as between different exposures is complicated and multifaceted, which leads to difficulties in linking disease or health outcomes with exposures. The large numbers of collected samples require well-designed logistics. Furthermore, the immense data sets generated from exposome studies require a significant computational investment for both data analysis and data storage. This report summarizes discussions during an international exposome symposium held at Gunma University in Japan regarding the concept of the exposome, challenges in exposome research, and future perspectives in the field.https://www.mdpi.com/2218-1989/9/6/106exposomemetabolomicsexposureepigeneticsenvironment |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Pei Zhang Manish Arora Romanas Chaleckis Tomohiko Isobe Mohit Jain Isabel Meister Erik Melén Matthew Perzanowski Federico Torta Markus R. Wenk Craig E. Wheelock |
spellingShingle |
Pei Zhang Manish Arora Romanas Chaleckis Tomohiko Isobe Mohit Jain Isabel Meister Erik Melén Matthew Perzanowski Federico Torta Markus R. Wenk Craig E. Wheelock Tackling the Complexity of the Exposome: Considerations from the Gunma University Initiative for Advanced Research (GIAR) Exposome Symposium Metabolites exposome metabolomics exposure epigenetics environment |
author_facet |
Pei Zhang Manish Arora Romanas Chaleckis Tomohiko Isobe Mohit Jain Isabel Meister Erik Melén Matthew Perzanowski Federico Torta Markus R. Wenk Craig E. Wheelock |
author_sort |
Pei Zhang |
title |
Tackling the Complexity of the Exposome: Considerations from the Gunma University Initiative for Advanced Research (GIAR) Exposome Symposium |
title_short |
Tackling the Complexity of the Exposome: Considerations from the Gunma University Initiative for Advanced Research (GIAR) Exposome Symposium |
title_full |
Tackling the Complexity of the Exposome: Considerations from the Gunma University Initiative for Advanced Research (GIAR) Exposome Symposium |
title_fullStr |
Tackling the Complexity of the Exposome: Considerations from the Gunma University Initiative for Advanced Research (GIAR) Exposome Symposium |
title_full_unstemmed |
Tackling the Complexity of the Exposome: Considerations from the Gunma University Initiative for Advanced Research (GIAR) Exposome Symposium |
title_sort |
tackling the complexity of the exposome: considerations from the gunma university initiative for advanced research (giar) exposome symposium |
publisher |
MDPI AG |
series |
Metabolites |
issn |
2218-1989 |
publishDate |
2019-06-01 |
description |
The attempt to describe complex diseases by solely genetic determination has not been successful. There is increasing recognition that the development of disease is often a consequence of interactions between multiple genetic and environmental factors. To date, much of the research on environmental determinants of disease has focused on single exposures generally measured at a single time point. In order to address this limitation, the concept of the exposome has been introduced as a comprehensive approach, studying the full complement of environmental exposures from conception onwards. However, exposures are vast, dynamic, and diverse, and only a small proportion can be reasonably measured due to limitations in technology and feasibility. In addition, the interplay between genes and exposure as well as between different exposures is complicated and multifaceted, which leads to difficulties in linking disease or health outcomes with exposures. The large numbers of collected samples require well-designed logistics. Furthermore, the immense data sets generated from exposome studies require a significant computational investment for both data analysis and data storage. This report summarizes discussions during an international exposome symposium held at Gunma University in Japan regarding the concept of the exposome, challenges in exposome research, and future perspectives in the field. |
topic |
exposome metabolomics exposure epigenetics environment |
url |
https://www.mdpi.com/2218-1989/9/6/106 |
work_keys_str_mv |
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