Occurrence of the <span style="font-variant: small-caps">d</span>-Proline Chemotype in Enzyme Inhibitors

Occurrence of the <span style="font-variant: small-caps">d</span>-Proline Chemotype in Enzyme Inhibitors

Natural and nonnatural amino acids represent important building blocks for the development of peptidomimetic scaffolds, especially for targeting proteolytic enzymes and for addressing protein–protein interactions. Among all the different amino acids derivatives, proline is particularly rel...

Full description

Bibliographic Details
Main Authors:	Elena Lenci, Andrea Trabocchi
Format:	Article
Language:	English
Published:	MDPI AG 2019-04-01
Series:	Symmetry
Subjects:	drug discovery amino acids peptidomimetics enzyme inhibitors chiral pool stereochemistry
Online Access:	https://www.mdpi.com/2073-8994/11/4/558

Similar Items

The Thermal Properties and Degradability of Chiral Polyester-Imides Based on Several <span style="font-variant: small-caps">l</span>/<span style="font-variant: small-caps">d</span>-Amino Acids
by: Chen Qi, et al.
Published: (2020-09-01)

A Surface Mediated Supramolecular Chiral Phenomenon for Recognition of <span style="font-variant: small-caps">l</span>- and <span style="font-variant: small-caps">d</span>-Cysteine
by: Jing Wang, et al.
Published: (2018-12-01)

Small Molecular Weight Aldose (<span style="font-variant: small-caps">d</span>-Glucose) and Basic Amino Acids (<span style="font-variant: small-caps">l</span>-Lysine, <span style="font-variant: small-caps">l</span>-Arginine) Increase the Occurrence of PAHs in Grilled Pork Sausages
by: Wen Nie, et al.
Published: (2018-12-01)

Heat Capacities of <span style="font-variant: small-caps">l</span>-Histidine, <span style="font-variant: small-caps">l</span>-Phenylalanine, <span style="font-variant: small-caps">l</span>-Proline, <span style="font-variant: small-caps">l</span>-Tryptophan and <span style="font-variant: small-caps">l</span>-Tyrosine
by: Václav Pokorný, et al.
Published: (2021-07-01)

The Effects of Oral <span style="font-variant: small-caps">l</span>-Arginine and <span style="font-variant: small-caps">l</span>-Citrulline Supplementation on Blood Pressure
by: David Khalaf, et al.
Published: (2019-07-01)

<span style="font-variant: small-caps;">d</span>-Idose, <span style="font-variant: small-caps;">d</span>-Iduronic Acid, and <span style="font-variant: small-caps;">d</span>-Idonic Acid from <span style="font-variant: small-caps;">d</span>-Glucose via Seven-Carbon Sugars
by: Zilei Liu, et al.
Published: (2019-10-01)

Simultaneous Analysis of <span style="font-variant: small-caps">d,l</span>-Amino Acids in Human Urine Using a Chirality-Switchable Biaryl Axial Tag and Liquid Chromatography Electrospray Ionization Tandem Mass Spectrometry
by: Masashi Harada, et al.
Published: (2020-06-01)

2,3-Diaminopropanols Obtained from <span style="font-variant: small-caps">d</span>-Serine as Intermediates in the Synthesis of Protected 2,3-<span style="font-variant: small-caps">l</span>-Diaminopropanoic Acid (<span style="font-variant: small-caps">l</span>-Dap) Methyl Esters
by: Andrea Temperini, et al.
Published: (2020-03-01)

Design, Synthesis of Novel Tetrandrine-14-<span style="font-variant: small-caps">l</span>-Amino Acid and Tetrandrine-14-<span style="font-variant: small-caps">l</span>-Amino Acid-Urea Derivatives as Potential Anti-Cancer Agents
by: Sheng-Cao Hu, et al.
Published: (2020-04-01)

α-<span style="font-variant: small-caps">d</span>-Glucopyranosyl-(1→2)-[6-<i>O</i>-(<span style="font-variant: small-caps">l</span>-tryptophanyl)-β-<span style="font-variant: small-caps">d</span>-fructofuranoside]
by: Kwaku Kyeremeh, et al.
Published: (2019-06-01)

<i><span style="font-variant: small-caps">d</span></i>-, <i><span style="font-variant: small-caps">l</span></i>- and <i><span style="font-variant: small-caps">d</span>,<span style="font-variant: small-caps">l</span></i>-Tryptophan-Based Polyamidoamino Acids: pH-Dependent Structuring and Fluorescent Properties
by: Federica Lazzari, et al.
Published: (2019-03-01)

<span style="font-variant: small-caps">l</span>-Cysteine and <span style="font-variant: small-caps">l</span>-Serine Modified Dendrimer with Multiple Reduced Thiols as a Kidney-Targeting Reactive Oxygen Species Scavenger to Prevent Renal Ischemia/Reperfusion Injury
by: Satoru Matsuura, et al.
Published: (2018-12-01)

2-Ketoglutarate-Generated In Vitro Enzymatic Biosystem Facilitates Fe(II)/2-Ketoglutarate-Dependent Dioxygenase-Mediated C–H Bond Oxidation for (2<i><span style="font-variant: small-caps">s</span></i>,3<i><span style="font-variant: small-caps">r</span></i>,4<i><span style="font-variant: small-caps">s</span></i>)-4-Hydroxyisoleucine Synthesis
by: Xiao-Ran Jing, et al.
Published: (2020-07-01)

Comparative Cerebroprotective Potential of <span style="font-variant: small-caps">d</span>- and <span style="font-variant: small-caps">l</span>-Carnosine Following Ischemic Stroke in Mice
by: Saurabh Jain, et al.
Published: (2020-04-01)

Effects of Dietary Supplementation with <span style="font-variant: small-caps">dl</span>-Methionine and <span style="font-variant: small-caps">dl</span>-Methionyl-<span style="font-variant: small-caps">dl</span>-Methionine in Breeding Pigeons on the Carcass Characteristics, Meat Quality and Antioxidant Activity of Squabs
by: Shi-Guang Jiang, et al.
Published: (2019-10-01)

Hydroxyapatite-poly(<span style="font-variant: small-caps">d</span>,<span style="font-variant: small-caps">l</span>-lactide) Nanografts. Synthesis and Characterization as Bone Cement Additives
by: Kristina L. Goranova, et al.
Published: (2021-01-01)

GTP Preference of <span style="font-variant: small-caps">d</span>-Glycero-α-<span style="font-variant: small-caps">d</span>-<i>manno</i>-Heptose-1-Phosphate Guanylyltransferase from <i>Yersinia pseudotuberculosis</i>
by: Suwon Kim, et al.
Published: (2019-12-01)

Solvothermal Preparation of a Lanthanide Metal-Organic Framework for Highly Sensitive Discrimination of Nitrofurantoin and <span style="font-variant: small-caps">l</span>-Tyrosine
by: Tian-Tian Wang, et al.
Published: (2021-06-01)

Chiral Cocrystal Solid Solutions, Molecular Complexes, and Salts of <i>N</i>-Triphenylacetyl-<span style="font-variant: small-caps">l</span>-Tyrosine and Diamines
by: Agnieszka Czapik, et al.
Published: (2019-10-01)

<span style="font-variant: small-caps">e</span>4<span style="font-variant: small-caps">clim</span> 1.0: The Energy for a Climate Integrated Model: Description and Application to Italy
by: Alexis Tantet, et al.
Published: (2019-11-01)

Synthesis and In Vitro Screening of Novel Heterocyclic β-<span style="font-variant: small-caps">d</span>-Gluco- and β-<span style="font-variant: small-caps">d</span>-Galactoconjugates as Butyrylcholinesterase Inhibitors
by: Krešimir Baumann, et al.
Published: (2019-08-01)

<span style="font-variant: small-caps">l</span>-Malate (−2) Protonation State is Required for Efficient Decarboxylation to <span style="font-variant: small-caps">l</span>-Lactate by the Malolactic Enzyme of <i>Oenococcus oeni</i>
by: Waldo Acevedo, et al.
Published: (2020-07-01)

Ground Displacement in East Azerbaijan Province, Iran, Revealed by <span style="font-variant: small-caps">L</span>-band and <span style="font-variant: small-caps">C</span>-band InSAR Analyses
by: Sadra Karimzadeh, et al.
Published: (2020-12-01)

Effect of In-Mold Annealing on the Properties of Asymmetric Poly(<span style="font-variant: small-caps">l</span>-lactide)/Poly(<span style="font-variant: small-caps">d</span>-lactide) Blends Incorporated with Nanohydroxyapatite
by: Martin Boruvka, et al.
Published: (2021-08-01)

Crystallization and Alkaline Degradation Behaviors of Poly(<span style="font-variant: small-caps">l</span>-Lactide)/4-Armed Poly(ε-Caprolactone)-Block-Poly(<span style="font-variant: small-caps">d</span>-Lactide) Blends with Different Poly(<span style="font-variant: small-caps">d</span>-Lactide) Block Lengths
by: Suyang Dai, et al.
Published: (2020-09-01)

'n Ondersoek na nuwe metodes vir die stereospesifieke sintese van heteroprostaglandiene
Published: (2015)

Structure Mediation and Properties of Poly(<i><span style="font-variant: small-caps">l</span></i>-lactide)/Poly(<i><span style="font-variant: small-caps">d</span></i>-lactide) Blend Fibers
by: Bo Yang, et al.
Published: (2018-12-01)

Structure–Activity Study, Characterization, and Mechanism of Action of an Antimicrobial Peptoid D2 and Its <span style="font-variant: small-caps">d</span>- and <span style="font-variant: small-caps">l</span>-Peptide Analogues
by: Ines Greco, et al.
Published: (2019-03-01)

Replacement of <span style="font-variant: small-caps">l</span>-Amino Acids by <span style="font-variant: small-caps">d</span>-Amino Acids in the Antimicrobial Peptide Ranalexin and Its Consequences for Antimicrobial Activity and Biodistribution
by: Cornelius Domhan, et al.
Published: (2019-08-01)

Surface Modification of Poly(<span style="font-variant: small-caps">l</span>-lactic acid) through Stereocomplexation with Enantiomeric Poly(<span style="font-variant: small-caps">d</span>-lactic acid) and Its Copolymer
by: Qianjin Zhu, et al.
Published: (2021-05-01)

Extracellular <span style="font-variant: small-caps">l</span>-arginine Enhances Relaxations Induced by Opening of Calcium-Activated SKCa Channels in Porcine Retinal Arteriole
by: Ulf Simonsen, et al.
Published: (2019-04-01)

<span style="font-variant: small-caps">d</span>-Cysteine-Induced Rapid Root Abscission in the Water Fern <i>Azolla Pinnata</i>: Implications for the Linkage between <span style="font-variant: small-caps">d</span>-Amino Acid and Reactive Sulfur Species (RSS) in Plant Environmental Responses
by: Hideo Yamasaki, et al.
Published: (2019-09-01)

<i>N</i>-Amino-<span style="font-variant: small-caps">l</span>-Proline Methyl Ester from an Australian Fish Gut-Derived Fungus: Challenging the Distinction between Natural Product and Artifact
by: Osama G. Mohamed, et al.
Published: (2021-03-01)

Fungal Enzyme <span style="font-variant: small-caps">l</span>-Lysine α-Oxidase Affects the Amino Acid Metabolism in the Brain and Decreases the Polyamine Level
by: Elena V. Lukasheva, et al.
Published: (2020-11-01)

Recent Strategies and Applications for <span style="font-variant: small-caps">l</span>-Asparaginase Confinement
by: João C. F. Nunes, et al.
Published: (2020-12-01)

<span style="font-variant: small-caps">d</span>-glutamate and Gut Microbiota in Alzheimer’s Disease
by: Chun-Hung Chang, et al.
Published: (2020-04-01)

<span style="font-variant: small-caps">l</span>-Lactate: Food for Thoughts, Memory and Behavior
by: María Fernanda Veloz Castillo, et al.
Published: (2021-08-01)

Variational Quantum Chemistry Programs in <span style="font-variant: small-caps">JaqalPaq</span>
by: Oliver G. Maupin, et al.
Published: (2021-05-01)

Poly(Ethylene Glycol)-<i>b</i>-Poly(<span style="font-variant: small-caps">d</span>,<span style="font-variant: small-caps">l</span>-Lactide) Nanoparticles as Potential Carriers for Anticancer Drug Oxaliplatin
by: Yulia A. Kadina, et al.
Published: (2021-01-01)

The Impact of a Large Bolus Dose of <span style="font-variant: small-caps">l</span>-leucine and <span style="font-variant: small-caps">l</span>-isoleucine on Enteroendocrine and Pancreatic Hormones, and Glycemia in Healthy, Inactive Adults
by: Daniel E. Newmire, et al.
Published: (2019-11-01)