Extremely Low-Frequency Magnetic Fields and Redox-Responsive Pathways Linked to Cancer Drug Resistance: Insights from Co-Exposure-Based In Vitro Studies
Electrical devices currently used in clinical practice and common household equipments generate extremely low-frequency magnetic fields (ELF-MF) that were classified by the International Agency for Research on Cancer as “possible carcinogenic.” Assuming that ELF-MF plays a role in the carcinogenic p...
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doaj-132b9f66cc944af1926bc61b805fad9a2020-11-24T22:52:38ZengFrontiers Media S.A.Frontiers in Public Health2296-25652018-02-01610.3389/fpubh.2018.00033318574Extremely Low-Frequency Magnetic Fields and Redox-Responsive Pathways Linked to Cancer Drug Resistance: Insights from Co-Exposure-Based In Vitro StudiesStefano Falone0Silvano Santini1Valeria Cordone2Giovanna Di Emidio3Carla Tatone4Marisa Cacchio5Fernanda Amicarelli6Fernanda Amicarelli7Department of Life, Health and Environmental Sciences, University of L’Aquila, L’Aquila, ItalyDepartment of Life, Health and Environmental Sciences, University of L’Aquila, L’Aquila, ItalyDepartment of Life, Health and Environmental Sciences, University of L’Aquila, L’Aquila, ItalyDepartment of Life, Health and Environmental Sciences, University of L’Aquila, L’Aquila, ItalyDepartment of Life, Health and Environmental Sciences, University of L’Aquila, L’Aquila, ItalyDepartment of Neurosciences, Imaging and Clinical Sciences, University “G. d’Annunzio”, Chieti, ItalyDepartment of Life, Health and Environmental Sciences, University of L’Aquila, L’Aquila, ItalyInstitute of Translational Pharmacology (IFT)—National Research Council (CNR), L’Aquila, ItalyElectrical devices currently used in clinical practice and common household equipments generate extremely low-frequency magnetic fields (ELF-MF) that were classified by the International Agency for Research on Cancer as “possible carcinogenic.” Assuming that ELF-MF plays a role in the carcinogenic process without inducing direct genomic alterations, ELF-MF may be involved in the promotion or progression of cancers. In particular, ELF-MF-induced responses are suspected to activate redox-responsive intracellular signaling or detoxification scavenging systems. In fact, improved protection against oxidative stress and redox-active xenobiotics is thought to provide critical proliferative and survival advantage in tumors. On this basis, an ever-growing research activity worldwide is attempting to establish whether tumor cells may develop multidrug resistance through the activation of essential cytoprotective networks in the presence of ELF fields, and how this might trigger relevant changes in tumor phenotype. This review builds a framework around how the activity of redox-responsive mediators may be controlled by co-exposure to ELF-MF and reactive oxygen species-generating agents in tumor and cancer cells, in order to clarify whether and how such potential molecular targets could help to minimize or neutralize the functional interaction between ELF-MF and malignancies.http://journal.frontiersin.org/article/10.3389/fpubh.2018.00033/fullchemoresistancereactive oxygen speciesglutathionecytotoxicitygenotoxicitycatalase |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Stefano Falone Silvano Santini Valeria Cordone Giovanna Di Emidio Carla Tatone Marisa Cacchio Fernanda Amicarelli Fernanda Amicarelli |
spellingShingle |
Stefano Falone Silvano Santini Valeria Cordone Giovanna Di Emidio Carla Tatone Marisa Cacchio Fernanda Amicarelli Fernanda Amicarelli Extremely Low-Frequency Magnetic Fields and Redox-Responsive Pathways Linked to Cancer Drug Resistance: Insights from Co-Exposure-Based In Vitro Studies Frontiers in Public Health chemoresistance reactive oxygen species glutathione cytotoxicity genotoxicity catalase |
author_facet |
Stefano Falone Silvano Santini Valeria Cordone Giovanna Di Emidio Carla Tatone Marisa Cacchio Fernanda Amicarelli Fernanda Amicarelli |
author_sort |
Stefano Falone |
title |
Extremely Low-Frequency Magnetic Fields and Redox-Responsive Pathways Linked to Cancer Drug Resistance: Insights from Co-Exposure-Based In Vitro Studies |
title_short |
Extremely Low-Frequency Magnetic Fields and Redox-Responsive Pathways Linked to Cancer Drug Resistance: Insights from Co-Exposure-Based In Vitro Studies |
title_full |
Extremely Low-Frequency Magnetic Fields and Redox-Responsive Pathways Linked to Cancer Drug Resistance: Insights from Co-Exposure-Based In Vitro Studies |
title_fullStr |
Extremely Low-Frequency Magnetic Fields and Redox-Responsive Pathways Linked to Cancer Drug Resistance: Insights from Co-Exposure-Based In Vitro Studies |
title_full_unstemmed |
Extremely Low-Frequency Magnetic Fields and Redox-Responsive Pathways Linked to Cancer Drug Resistance: Insights from Co-Exposure-Based In Vitro Studies |
title_sort |
extremely low-frequency magnetic fields and redox-responsive pathways linked to cancer drug resistance: insights from co-exposure-based in vitro studies |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Public Health |
issn |
2296-2565 |
publishDate |
2018-02-01 |
description |
Electrical devices currently used in clinical practice and common household equipments generate extremely low-frequency magnetic fields (ELF-MF) that were classified by the International Agency for Research on Cancer as “possible carcinogenic.” Assuming that ELF-MF plays a role in the carcinogenic process without inducing direct genomic alterations, ELF-MF may be involved in the promotion or progression of cancers. In particular, ELF-MF-induced responses are suspected to activate redox-responsive intracellular signaling or detoxification scavenging systems. In fact, improved protection against oxidative stress and redox-active xenobiotics is thought to provide critical proliferative and survival advantage in tumors. On this basis, an ever-growing research activity worldwide is attempting to establish whether tumor cells may develop multidrug resistance through the activation of essential cytoprotective networks in the presence of ELF fields, and how this might trigger relevant changes in tumor phenotype. This review builds a framework around how the activity of redox-responsive mediators may be controlled by co-exposure to ELF-MF and reactive oxygen species-generating agents in tumor and cancer cells, in order to clarify whether and how such potential molecular targets could help to minimize or neutralize the functional interaction between ELF-MF and malignancies. |
topic |
chemoresistance reactive oxygen species glutathione cytotoxicity genotoxicity catalase |
url |
http://journal.frontiersin.org/article/10.3389/fpubh.2018.00033/full |
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