STRUCTURAL CHANGES OF THE PLACENTAL COMPLEX IN DYSFUNCTION OF PLACENT IN MICROGEN

• Main Authors: V. V. Ovcharuk, A. V. Boychuk, Yu. M. Orel
• Format: Article
• Language: Ukrainian
• Published: Ukrmedknyha Publishing House 2017-11-01
• Series: Vіsnik Naukovih Doslіdžen'
• Subjects: вагітна; породілля; плацентарна дисфункція; плід; плацента; тивортин; левокарнітин.
• Online Access: https://ojs.tdmu.edu.ua/index.php/visnyk-nauk-dos/article/view/8084

Indicators of perinatal morbidity and mortality are among the main criteria for assessing the health status of the state of the World Health Organization. The placental dysfunction complicates the condition of the uterus, which manifests itself as a delay in its growth, plays an important role in the structure of perinatal morbidity and mortality. The aim of the study – to evaluate the morphofunctional changes in the poster of healthy childbirths and to conduct a comparative study with placenta of pregnant women, diagnosed with placental dysfunction, who received treatment according to the generally accepted and proposed methodology. Materials and Methods. We studied morphofunctional changes in the litter in 30 healthy children and conducted a comparative analysis of the placenta in 60 births with diagnosed placental dysfunction, among them 30 pregnant women received treatment according to the generally accepted method and 30 proposed treatments. Research and Discussion. It was revealed that the complex therapy of placental dysfunction with the use of tivortin and L-carnitine reduces the intensity of pathological structural changes in the litter, in particular due to the improvement of the morphofunctional state of the blood stream. Conclusions. In the course of the physiological course of pregnancy, there is often a placid, as well as an intermediate type of blood supply to the placenta, which provide optimal conditions for hemodynamics in its vascular bed. Integrated therapy of placental dysfunction with the use of tyvortine and L-carnitine reduces the intensity of pathological structural changes in the litter, in particular due to the improvement of the morphofunctional state of the bloodstream, and also facilitates the activation of adaptive-compensatory processes in the placenta, which results in improved metabolic processes in the system mother-placenta-fetus.