Effect of minimally invasive craniotomy combined with edaravone on cerebral oxygen metabolism, cerebrovascular function and oxidative stress in patients with acute cerebral hemorrhage
Objective: To investigate the effects of minimally invasive craniotomy combined with edaravone on cerebral oxygen metabolism, cerebrovascular function and oxidative stress in patients with acute cerebral hemorrhage. Methods: A total of 100 patients with acute cerebral hemorrhage treated in our ho...
Main Authors: | , , |
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Format: | Article |
Language: | English |
Published: |
Editorial Board of Journal of Hainan Medical University
2018-08-01
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Series: | Journal of Hainan Medical University |
Subjects: | |
Online Access: | http://www.hnykdxxb.com/PDF/201808/15.pdf |
Summary: | Objective: To investigate the effects of minimally invasive craniotomy combined with
edaravone on cerebral oxygen metabolism, cerebrovascular function and oxidative stress in
patients with acute cerebral hemorrhage. Methods: A total of 100 patients with acute cerebral
hemorrhage treated in our hospital from March 2015 to February 2017 were randomly divided
into control group and observation group. 50 patients in the control group were treated with
minimally invasive craniotomy. On the basis of control group, patients in the observation
group were treated with edaravone. Cerebral oxygen metabolism, cerebrovascular function
and oxidative stress were measured later in both groups. Results: After treatment, the levels
of SOD in both groups increased significantly and MDA levels decreased significantly, and
SOD level in the observation group was (97.34±1.95) U/mL, which was significantly higher
than the control group, MDA level was (2.77±0.11) mol/L and significantly lower than that
of the control group after treatment; After treatment, the levels of ET in both groups were
significantly lower than those before treatment, and the levels of CGRP were significantly
higher than those before treatment. ET level in observation group was (3.24±0.22) μg/L after
treatment, which was significantly lower than that in control group (59.67±0.79) pg/mL, which
was significantly higher than the control group; After treatment, the levels of SjvO2, CjvO2
and PbtO2 in both groups were significantly increased compared with before treatment, the
levels of Da-jvO2 and CEO2 were significantly lower than the level of before treatment, and
the levels of SjvO2, The levels of CjvO2 and PbtO2 were (62.93±1.63)%, (99.31±0.94) mL/
L and (28.56±1.55) mmHg, which were significantly higher than the control group. Da-jvO2
and CEO2 levels were (51.31±1.13) mL/L and (30.52±0.43)%, which were significantly lower
than the control group. Conclusion: Edaravone combined with minimally invasive craniotomy
can effectively reduce the level of oxidative stress, improve endothelial function and cerebral
oxygen metabolism, and has reliable curative effect. It is worth further clinical application. |
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ISSN: | 1007-1237 1007-1237 |