Silylaryl triflates in the formation of arynes with application in the preparation of N,N-diarylamino acid derivatives
<p><strong><em></em></strong><em>Through this work we are developing our research involving the formation of arynes from 2-(trimethylsilyl)aryl triflates, under relatively mild reaction conditions. Thus, esters of amino acids are being subjected to the reaction wi...
Main Authors: | , , |
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Format: | Article |
Language: | English |
Published: |
Universidade Federal de Mato Grosso do Sul
2012-06-01
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Series: | Orbital: The Electronic Journal of Chemistry |
Subjects: | |
Online Access: | http://orbital.ufms.br/index.php/Chemistry/article/view/379 |
Summary: | <p><strong><em></em></strong><em>Through this work we are developing our research involving the formation of arynes from 2-(trimethylsilyl)aryl triflates, under relatively mild reaction conditions. Thus, esters of amino acids are being subjected to the reaction with 2-(trimethylsilyl)aryl triflates, using cesium fluoride in acetonitrile at 80<sup>o</sup>C for 24 h, resulting in the formation of N,N-diarylamino acid derivatives, important chiral intermediates in the construction of peptides and drugs.</em></p> |
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ISSN: | 1984-6428 |