Silylaryl triflates in the formation of arynes with application in the preparation of N,N-diarylamino acid derivatives
<p><strong><em></em></strong><em>Through this work we are developing our research involving the formation of arynes from 2-(trimethylsilyl)aryl triflates, under relatively mild reaction conditions. Thus, esters of amino acids are being subjected to the reaction wi...
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Universidade Federal de Mato Grosso do Sul
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doaj-13337e341c2642e7a978d189685880512021-07-07T19:22:34ZengUniversidade Federal de Mato Grosso do SulOrbital: The Electronic Journal of Chemistry1984-64282012-06-0141828310.17807/orbital.v4i1.379148Silylaryl triflates in the formation of arynes with application in the preparation of N,N-diarylamino acid derivativesDanilo Y. Albuquerque0Irlon M. Ferreira1Cristiano RaminelliFaculdade de Ciências Exatas e Tecnologia, Universidade Federal da Grande Dourados, Dourados, MSFaculdade de Ciências Exatas e Tecnologia, Universidade Federal da Grande Dourados, Dourados, MS<p><strong><em></em></strong><em>Through this work we are developing our research involving the formation of arynes from 2-(trimethylsilyl)aryl triflates, under relatively mild reaction conditions. Thus, esters of amino acids are being subjected to the reaction with 2-(trimethylsilyl)aryl triflates, using cesium fluoride in acetonitrile at 80<sup>o</sup>C for 24 h, resulting in the formation of N,N-diarylamino acid derivatives, important chiral intermediates in the construction of peptides and drugs.</em></p>http://orbital.ufms.br/index.php/Chemistry/article/view/379benzyne chemistrysilylaryl triflatesunnatural amino acids |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Danilo Y. Albuquerque Irlon M. Ferreira Cristiano Raminelli |
spellingShingle |
Danilo Y. Albuquerque Irlon M. Ferreira Cristiano Raminelli Silylaryl triflates in the formation of arynes with application in the preparation of N,N-diarylamino acid derivatives Orbital: The Electronic Journal of Chemistry benzyne chemistry silylaryl triflates unnatural amino acids |
author_facet |
Danilo Y. Albuquerque Irlon M. Ferreira Cristiano Raminelli |
author_sort |
Danilo Y. Albuquerque |
title |
Silylaryl triflates in the formation of arynes with application in the preparation of N,N-diarylamino acid derivatives |
title_short |
Silylaryl triflates in the formation of arynes with application in the preparation of N,N-diarylamino acid derivatives |
title_full |
Silylaryl triflates in the formation of arynes with application in the preparation of N,N-diarylamino acid derivatives |
title_fullStr |
Silylaryl triflates in the formation of arynes with application in the preparation of N,N-diarylamino acid derivatives |
title_full_unstemmed |
Silylaryl triflates in the formation of arynes with application in the preparation of N,N-diarylamino acid derivatives |
title_sort |
silylaryl triflates in the formation of arynes with application in the preparation of n,n-diarylamino acid derivatives |
publisher |
Universidade Federal de Mato Grosso do Sul |
series |
Orbital: The Electronic Journal of Chemistry |
issn |
1984-6428 |
publishDate |
2012-06-01 |
description |
<p><strong><em></em></strong><em>Through this work we are developing our research involving the formation of arynes from 2-(trimethylsilyl)aryl triflates, under relatively mild reaction conditions. Thus, esters of amino acids are being subjected to the reaction with 2-(trimethylsilyl)aryl triflates, using cesium fluoride in acetonitrile at 80<sup>o</sup>C for 24 h, resulting in the formation of N,N-diarylamino acid derivatives, important chiral intermediates in the construction of peptides and drugs.</em></p> |
topic |
benzyne chemistry silylaryl triflates unnatural amino acids |
url |
http://orbital.ufms.br/index.php/Chemistry/article/view/379 |
work_keys_str_mv |
AT daniloyalbuquerque silylaryltriflatesintheformationofaryneswithapplicationinthepreparationofnndiarylaminoacidderivatives AT irlonmferreira silylaryltriflatesintheformationofaryneswithapplicationinthepreparationofnndiarylaminoacidderivatives AT cristianoraminelli silylaryltriflatesintheformationofaryneswithapplicationinthepreparationofnndiarylaminoacidderivatives |
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1721314839218880512 |