Silylaryl triflates in the formation of arynes with application in the preparation of N,N-diarylamino acid derivatives

Silylaryl triflates in the formation of arynes with application in the preparation of N,N-diarylamino acid derivatives

<p><strong><em></em></strong><em>Through this work we are developing our research involving the formation of arynes from 2-(trimethylsilyl)aryl triflates, under relatively mild reaction conditions. Thus, esters of amino acids are being subjected to the reaction wi...

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Main Authors: Danilo Y. Albuquerque, Irlon M. Ferreira, Cristiano Raminelli
Format: Article
Language:English
Published: Universidade Federal de Mato Grosso do Sul 2012-06-01
Series:Orbital: The Electronic Journal of Chemistry
Subjects:
benzyne chemistry
silylaryl triflates
unnatural amino acids
Online Access:http://orbital.ufms.br/index.php/Chemistry/article/view/379
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spelling doaj-13337e341c2642e7a978d189685880512021-07-07T19:22:34ZengUniversidade Federal de Mato Grosso do SulOrbital: The Electronic Journal of Chemistry1984-64282012-06-0141828310.17807/orbital.v4i1.379148Silylaryl triflates in the formation of arynes with application in the preparation of N,N-diarylamino acid derivativesDanilo Y. Albuquerque0Irlon M. Ferreira1Cristiano RaminelliFaculdade de Ciências Exatas e Tecnologia, Universidade Federal da Grande Dourados, Dourados, MSFaculdade de Ciências Exatas e Tecnologia, Universidade Federal da Grande Dourados, Dourados, MS<p><strong><em></em></strong><em>Through this work we are developing our research involving the formation of arynes from 2-(trimethylsilyl)aryl triflates, under relatively mild reaction conditions. Thus, esters of amino acids are being subjected to the reaction with 2-(trimethylsilyl)aryl triflates, using cesium fluoride in acetonitrile at 80<sup>o</sup>C for 24 h, resulting in the formation of N,N-diarylamino acid derivatives, important chiral intermediates in the construction of peptides and drugs.</em></p>http://orbital.ufms.br/index.php/Chemistry/article/view/379benzyne chemistrysilylaryl triflatesunnatural amino acids
collection DOAJ
language English
format Article
sources DOAJ
author Danilo Y. Albuquerque
Irlon M. Ferreira
Cristiano Raminelli
spellingShingle Danilo Y. Albuquerque
Irlon M. Ferreira
Cristiano Raminelli
Silylaryl triflates in the formation of arynes with application in the preparation of N,N-diarylamino acid derivatives
Orbital: The Electronic Journal of Chemistry
benzyne chemistry
silylaryl triflates
unnatural amino acids
author_facet Danilo Y. Albuquerque
Irlon M. Ferreira
Cristiano Raminelli
author_sort Danilo Y. Albuquerque
title Silylaryl triflates in the formation of arynes with application in the preparation of N,N-diarylamino acid derivatives
title_short Silylaryl triflates in the formation of arynes with application in the preparation of N,N-diarylamino acid derivatives
title_full Silylaryl triflates in the formation of arynes with application in the preparation of N,N-diarylamino acid derivatives
title_fullStr Silylaryl triflates in the formation of arynes with application in the preparation of N,N-diarylamino acid derivatives
title_full_unstemmed Silylaryl triflates in the formation of arynes with application in the preparation of N,N-diarylamino acid derivatives
title_sort silylaryl triflates in the formation of arynes with application in the preparation of n,n-diarylamino acid derivatives
publisher Universidade Federal de Mato Grosso do Sul
series Orbital: The Electronic Journal of Chemistry
issn 1984-6428
publishDate 2012-06-01
description <p><strong><em></em></strong><em>Through this work we are developing our research involving the formation of arynes from 2-(trimethylsilyl)aryl triflates, under relatively mild reaction conditions. Thus, esters of amino acids are being subjected to the reaction with 2-(trimethylsilyl)aryl triflates, using cesium fluoride in acetonitrile at 80<sup>o</sup>C for 24 h, resulting in the formation of N,N-diarylamino acid derivatives, important chiral intermediates in the construction of peptides and drugs.</em></p>
topic benzyne chemistry
silylaryl triflates
unnatural amino acids
url http://orbital.ufms.br/index.php/Chemistry/article/view/379
work_keys_str_mv AT daniloyalbuquerque silylaryltriflatesintheformationofaryneswithapplicationinthepreparationofnndiarylaminoacidderivatives
AT irlonmferreira silylaryltriflatesintheformationofaryneswithapplicationinthepreparationofnndiarylaminoacidderivatives
AT cristianoraminelli silylaryltriflatesintheformationofaryneswithapplicationinthepreparationofnndiarylaminoacidderivatives
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