Natural Cinnamic Acids, Synthetic Derivatives and Hybrids with Antimicrobial Activity

Antimicrobial natural preparations involving cinnamon, storax and propolis have been long used topically for treating infections. Cinnamic acids and related molecules are partly responsible for the therapeutic effects observed in these preparations. Most of the cinnamic acids, their esters, amides,...

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Main Author: Juan David Guzman
Format: Article
Language:English
Published: MDPI AG 2014-11-01
Series:Molecules
Subjects:
Online Access:http://www.mdpi.com/1420-3049/19/12/19292
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spelling doaj-1333dbfacf054ed8a7657e4eef9693e72020-11-25T00:14:24ZengMDPI AGMolecules1420-30492014-11-011912192921934910.3390/molecules191219292molecules191219292Natural Cinnamic Acids, Synthetic Derivatives and Hybrids with Antimicrobial ActivityJuan David Guzman0Departamento de Química y Biología, División de Ciencias Básicas, Universidad del Norte, Km. 5 vía Puerto Colombia, Barranquilla 081007, ColombiaAntimicrobial natural preparations involving cinnamon, storax and propolis have been long used topically for treating infections. Cinnamic acids and related molecules are partly responsible for the therapeutic effects observed in these preparations. Most of the cinnamic acids, their esters, amides, aldehydes and alcohols, show significant growth inhibition against one or several bacterial and fungal species. Of particular interest is the potent antitubercular activity observed for some of these cinnamic derivatives, which may be amenable as future drugs for treating tuberculosis. This review intends to summarize the literature data on the antimicrobial activity of the natural cinnamic acids and related derivatives. In addition, selected hybrids between cinnamic acids and biologically active scaffolds with antimicrobial activity were also included. A comprehensive literature search was performed collating the minimum inhibitory concentration (MIC) of each cinnamic acid or derivative against the reported microorganisms. The MIC data allows the relative comparison between series of molecules and the derivation of structure-activity relationships.http://www.mdpi.com/1420-3049/19/12/19292cinnamic acidcoumaric acidshybridsantimicrobialtuberculosis
collection DOAJ
language English
format Article
sources DOAJ
author Juan David Guzman
spellingShingle Juan David Guzman
Natural Cinnamic Acids, Synthetic Derivatives and Hybrids with Antimicrobial Activity
Molecules
cinnamic acid
coumaric acids
hybrids
antimicrobial
tuberculosis
author_facet Juan David Guzman
author_sort Juan David Guzman
title Natural Cinnamic Acids, Synthetic Derivatives and Hybrids with Antimicrobial Activity
title_short Natural Cinnamic Acids, Synthetic Derivatives and Hybrids with Antimicrobial Activity
title_full Natural Cinnamic Acids, Synthetic Derivatives and Hybrids with Antimicrobial Activity
title_fullStr Natural Cinnamic Acids, Synthetic Derivatives and Hybrids with Antimicrobial Activity
title_full_unstemmed Natural Cinnamic Acids, Synthetic Derivatives and Hybrids with Antimicrobial Activity
title_sort natural cinnamic acids, synthetic derivatives and hybrids with antimicrobial activity
publisher MDPI AG
series Molecules
issn 1420-3049
publishDate 2014-11-01
description Antimicrobial natural preparations involving cinnamon, storax and propolis have been long used topically for treating infections. Cinnamic acids and related molecules are partly responsible for the therapeutic effects observed in these preparations. Most of the cinnamic acids, their esters, amides, aldehydes and alcohols, show significant growth inhibition against one or several bacterial and fungal species. Of particular interest is the potent antitubercular activity observed for some of these cinnamic derivatives, which may be amenable as future drugs for treating tuberculosis. This review intends to summarize the literature data on the antimicrobial activity of the natural cinnamic acids and related derivatives. In addition, selected hybrids between cinnamic acids and biologically active scaffolds with antimicrobial activity were also included. A comprehensive literature search was performed collating the minimum inhibitory concentration (MIC) of each cinnamic acid or derivative against the reported microorganisms. The MIC data allows the relative comparison between series of molecules and the derivation of structure-activity relationships.
topic cinnamic acid
coumaric acids
hybrids
antimicrobial
tuberculosis
url http://www.mdpi.com/1420-3049/19/12/19292
work_keys_str_mv AT juandavidguzman naturalcinnamicacidssyntheticderivativesandhybridswithantimicrobialactivity
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