Natural Cinnamic Acids, Synthetic Derivatives and Hybrids with Antimicrobial Activity
Antimicrobial natural preparations involving cinnamon, storax and propolis have been long used topically for treating infections. Cinnamic acids and related molecules are partly responsible for the therapeutic effects observed in these preparations. Most of the cinnamic acids, their esters, amides,...
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Online Access: | http://www.mdpi.com/1420-3049/19/12/19292 |
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doaj-1333dbfacf054ed8a7657e4eef9693e72020-11-25T00:14:24ZengMDPI AGMolecules1420-30492014-11-011912192921934910.3390/molecules191219292molecules191219292Natural Cinnamic Acids, Synthetic Derivatives and Hybrids with Antimicrobial ActivityJuan David Guzman0Departamento de Química y Biología, División de Ciencias Básicas, Universidad del Norte, Km. 5 vía Puerto Colombia, Barranquilla 081007, ColombiaAntimicrobial natural preparations involving cinnamon, storax and propolis have been long used topically for treating infections. Cinnamic acids and related molecules are partly responsible for the therapeutic effects observed in these preparations. Most of the cinnamic acids, their esters, amides, aldehydes and alcohols, show significant growth inhibition against one or several bacterial and fungal species. Of particular interest is the potent antitubercular activity observed for some of these cinnamic derivatives, which may be amenable as future drugs for treating tuberculosis. This review intends to summarize the literature data on the antimicrobial activity of the natural cinnamic acids and related derivatives. In addition, selected hybrids between cinnamic acids and biologically active scaffolds with antimicrobial activity were also included. A comprehensive literature search was performed collating the minimum inhibitory concentration (MIC) of each cinnamic acid or derivative against the reported microorganisms. The MIC data allows the relative comparison between series of molecules and the derivation of structure-activity relationships.http://www.mdpi.com/1420-3049/19/12/19292cinnamic acidcoumaric acidshybridsantimicrobialtuberculosis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Juan David Guzman |
spellingShingle |
Juan David Guzman Natural Cinnamic Acids, Synthetic Derivatives and Hybrids with Antimicrobial Activity Molecules cinnamic acid coumaric acids hybrids antimicrobial tuberculosis |
author_facet |
Juan David Guzman |
author_sort |
Juan David Guzman |
title |
Natural Cinnamic Acids, Synthetic Derivatives and Hybrids with Antimicrobial Activity |
title_short |
Natural Cinnamic Acids, Synthetic Derivatives and Hybrids with Antimicrobial Activity |
title_full |
Natural Cinnamic Acids, Synthetic Derivatives and Hybrids with Antimicrobial Activity |
title_fullStr |
Natural Cinnamic Acids, Synthetic Derivatives and Hybrids with Antimicrobial Activity |
title_full_unstemmed |
Natural Cinnamic Acids, Synthetic Derivatives and Hybrids with Antimicrobial Activity |
title_sort |
natural cinnamic acids, synthetic derivatives and hybrids with antimicrobial activity |
publisher |
MDPI AG |
series |
Molecules |
issn |
1420-3049 |
publishDate |
2014-11-01 |
description |
Antimicrobial natural preparations involving cinnamon, storax and propolis have been long used topically for treating infections. Cinnamic acids and related molecules are partly responsible for the therapeutic effects observed in these preparations. Most of the cinnamic acids, their esters, amides, aldehydes and alcohols, show significant growth inhibition against one or several bacterial and fungal species. Of particular interest is the potent antitubercular activity observed for some of these cinnamic derivatives, which may be amenable as future drugs for treating tuberculosis. This review intends to summarize the literature data on the antimicrobial activity of the natural cinnamic acids and related derivatives. In addition, selected hybrids between cinnamic acids and biologically active scaffolds with antimicrobial activity were also included. A comprehensive literature search was performed collating the minimum inhibitory concentration (MIC) of each cinnamic acid or derivative against the reported microorganisms. The MIC data allows the relative comparison between series of molecules and the derivation of structure-activity relationships. |
topic |
cinnamic acid coumaric acids hybrids antimicrobial tuberculosis |
url |
http://www.mdpi.com/1420-3049/19/12/19292 |
work_keys_str_mv |
AT juandavidguzman naturalcinnamicacidssyntheticderivativesandhybridswithantimicrobialactivity |
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