Histochemical characterization of human osteochondral tissue: comparison between healthy cartilage, arthrotic tissues, and cartilage defect treated with MACI technique

Histochemical characterization of human osteochondral tissue: comparison between healthy cartilage, arthrotic tissues, and cartilage defect treated with MACI technique

Matrix-induced sutologous chondrocytes implantation (MACI) is a promising technique for the treatment of articular cartilage lesions, but long time outcome have to be established. We developed and optimized specific techniques of histochemical staining to characterize healthy and pathologic osteocho...

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Main Authors: F. Tessarolo, R. Tatti, M. Molinari, P. Dorigotti, R. Antolini, G. Nollo
Format: Article
Language:English
Published: PAGEPress Publications 2011-01-01
Series:Journal of Biological Research
Subjects:
MACI, cartilage, knee, chondrocytes, histochemistry
Online Access:http://www.pagepressjournals.org/index.php/jbr/article/view/4688
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spelling doaj-1342d965dadb40b083757bb62098132d2020-11-25T02:05:29ZengPAGEPress PublicationsJournal of Biological Research1826-88382284-02302011-01-0184110.4081/jbr.2011.46883835Histochemical characterization of human osteochondral tissue: comparison between healthy cartilage, arthrotic tissues, and cartilage defect treated with MACI techniqueF. TessaroloR. TattiM. MolinariP. DorigottiR. AntoliniG. NolloMatrix-induced sutologous chondrocytes implantation (MACI) is a promising technique for the treatment of articular cartilage lesions, but long time outcome have to be established. We developed and optimized specific techniques of histochemical staining to characterize healthy and pathologic osteochondral tissue. Seven different staining protocols were applied to assess tissue architecture, cells morphology, proteoglycan content, and collagen fibers distribution. Potentialities of histochemical staining and histomorphology of biopsies from second look arthroscopy will be presented.http://www.pagepressjournals.org/index.php/jbr/article/view/4688MACI, cartilage, knee, chondrocytes, histochemistry
collection DOAJ
language English
format Article
sources DOAJ
author F. Tessarolo
R. Tatti
M. Molinari
P. Dorigotti
R. Antolini
G. Nollo
spellingShingle F. Tessarolo
R. Tatti
M. Molinari
P. Dorigotti
R. Antolini
G. Nollo
Histochemical characterization of human osteochondral tissue: comparison between healthy cartilage, arthrotic tissues, and cartilage defect treated with MACI technique
Journal of Biological Research
MACI, cartilage, knee, chondrocytes, histochemistry
author_facet F. Tessarolo
R. Tatti
M. Molinari
P. Dorigotti
R. Antolini
G. Nollo
author_sort F. Tessarolo
title Histochemical characterization of human osteochondral tissue: comparison between healthy cartilage, arthrotic tissues, and cartilage defect treated with MACI technique
title_short Histochemical characterization of human osteochondral tissue: comparison between healthy cartilage, arthrotic tissues, and cartilage defect treated with MACI technique
title_full Histochemical characterization of human osteochondral tissue: comparison between healthy cartilage, arthrotic tissues, and cartilage defect treated with MACI technique
title_fullStr Histochemical characterization of human osteochondral tissue: comparison between healthy cartilage, arthrotic tissues, and cartilage defect treated with MACI technique
title_full_unstemmed Histochemical characterization of human osteochondral tissue: comparison between healthy cartilage, arthrotic tissues, and cartilage defect treated with MACI technique
title_sort histochemical characterization of human osteochondral tissue: comparison between healthy cartilage, arthrotic tissues, and cartilage defect treated with maci technique
publisher PAGEPress Publications
series Journal of Biological Research
issn 1826-8838
2284-0230
publishDate 2011-01-01
description Matrix-induced sutologous chondrocytes implantation (MACI) is a promising technique for the treatment of articular cartilage lesions, but long time outcome have to be established. We developed and optimized specific techniques of histochemical staining to characterize healthy and pathologic osteochondral tissue. Seven different staining protocols were applied to assess tissue architecture, cells morphology, proteoglycan content, and collagen fibers distribution. Potentialities of histochemical staining and histomorphology of biopsies from second look arthroscopy will be presented.
topic MACI, cartilage, knee, chondrocytes, histochemistry
url http://www.pagepressjournals.org/index.php/jbr/article/view/4688
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AT rtatti histochemicalcharacterizationofhumanosteochondraltissuecomparisonbetweenhealthycartilagearthrotictissuesandcartilagedefecttreatedwithmacitechnique
AT mmolinari histochemicalcharacterizationofhumanosteochondraltissuecomparisonbetweenhealthycartilagearthrotictissuesandcartilagedefecttreatedwithmacitechnique
AT pdorigotti histochemicalcharacterizationofhumanosteochondraltissuecomparisonbetweenhealthycartilagearthrotictissuesandcartilagedefecttreatedwithmacitechnique
AT rantolini histochemicalcharacterizationofhumanosteochondraltissuecomparisonbetweenhealthycartilagearthrotictissuesandcartilagedefecttreatedwithmacitechnique
AT gnollo histochemicalcharacterizationofhumanosteochondraltissuecomparisonbetweenhealthycartilagearthrotictissuesandcartilagedefecttreatedwithmacitechnique
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