Progress of the relationship between serum uric acid and neurodegenerative diseases

• Main Authors: Yang FU, Jian-fang MA, Sheng-di CHEN
• Format: Article
• Language: English
• Published: Tianjin Huanhu Hospital 2018-03-01
• Series: Chinese Journal of Contemporary Neurology and Neurosurgery
• Subjects: Uric acid; Parkinson disease; Alzheimer disease; Amyotrophic lateral sclerosis; Multiple system atrophy; Review
• Online Access: http://www.cjcnn.org/index.php/cjcnn/article/view/1752
• ISSN: 1672-6731

Serum uric acid (sUA), a natural antioxidant in human body, has been found to be related to the occurrence and development of various neurodegenerative diseases in recent years, including Parkinson's disease (PD), multiple system atrophy (MSA), Alzheimer's disease (AD) and amyotrophic lateral sclerosis (ALS). Increasing of sUA level has been found to reduce the incidence of PD and ALS, but the relationship between sUA and AD, MSA remains largely unknown. The in vitro studies and animal experiments revealed that sUA can enhance the antioxidant capacity of neurons and delay neurodegeneration and apoptosis. This paper mainly reviews the progress in epidemiological and basic studies of the relationship between sUA and neurodegenerative diseases in recent years, and aims to provide a reference for future novel prevention and treatment strategies for neurodegenerative diseases. DOI: 10.3969/j.issn.1672-6731.2018.03.010