Progress of the relationship between serum uric acid and neurodegenerative diseases
Serum uric acid (sUA), a natural antioxidant in human body, has been found to be related to the occurrence and development of various neurodegenerative diseases in recent years, including Parkinson's disease (PD), multiple system atrophy (MSA), Alzheimer's disease (AD) and amyotrophic late...
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Tianjin Huanhu Hospital
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doaj-1348f193db3340e99551eac1f9ca6e752020-11-24T23:48:14ZengTianjin Huanhu HospitalChinese Journal of Contemporary Neurology and Neurosurgery1672-67312018-03-011832042121709Progress of the relationship between serum uric acid and neurodegenerative diseasesYang FU0Jian-fang MA1Sheng-di CHEN2Department of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, ChinaDepartment of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, ChinaDepartment of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, ChinaSerum uric acid (sUA), a natural antioxidant in human body, has been found to be related to the occurrence and development of various neurodegenerative diseases in recent years, including Parkinson's disease (PD), multiple system atrophy (MSA), Alzheimer's disease (AD) and amyotrophic lateral sclerosis (ALS). Increasing of sUA level has been found to reduce the incidence of PD and ALS, but the relationship between sUA and AD, MSA remains largely unknown. The in vitro studies and animal experiments revealed that sUA can enhance the antioxidant capacity of neurons and delay neurodegeneration and apoptosis. This paper mainly reviews the progress in epidemiological and basic studies of the relationship between sUA and neurodegenerative diseases in recent years, and aims to provide a reference for future novel prevention and treatment strategies for neurodegenerative diseases. DOI: 10.3969/j.issn.1672-6731.2018.03.010http://www.cjcnn.org/index.php/cjcnn/article/view/1752Uric acidParkinson diseaseAlzheimer diseaseAmyotrophic lateral sclerosisMultiple system atrophyReview |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yang FU Jian-fang MA Sheng-di CHEN |
spellingShingle |
Yang FU Jian-fang MA Sheng-di CHEN Progress of the relationship between serum uric acid and neurodegenerative diseases Chinese Journal of Contemporary Neurology and Neurosurgery Uric acid Parkinson disease Alzheimer disease Amyotrophic lateral sclerosis Multiple system atrophy Review |
author_facet |
Yang FU Jian-fang MA Sheng-di CHEN |
author_sort |
Yang FU |
title |
Progress of the relationship between serum uric acid and neurodegenerative diseases |
title_short |
Progress of the relationship between serum uric acid and neurodegenerative diseases |
title_full |
Progress of the relationship between serum uric acid and neurodegenerative diseases |
title_fullStr |
Progress of the relationship between serum uric acid and neurodegenerative diseases |
title_full_unstemmed |
Progress of the relationship between serum uric acid and neurodegenerative diseases |
title_sort |
progress of the relationship between serum uric acid and neurodegenerative diseases |
publisher |
Tianjin Huanhu Hospital |
series |
Chinese Journal of Contemporary Neurology and Neurosurgery |
issn |
1672-6731 |
publishDate |
2018-03-01 |
description |
Serum uric acid (sUA), a natural antioxidant in human body, has been found to be related to the occurrence and development of various neurodegenerative diseases in recent years, including Parkinson's disease (PD), multiple system atrophy (MSA), Alzheimer's disease (AD) and amyotrophic lateral sclerosis (ALS). Increasing of sUA level has been found to reduce the incidence of PD and ALS, but the relationship between sUA and AD, MSA remains largely unknown. The in vitro studies and animal experiments revealed that sUA can enhance the antioxidant capacity of neurons and delay neurodegeneration and apoptosis. This paper mainly reviews the progress in epidemiological and basic studies of the relationship between sUA and neurodegenerative diseases in recent years, and aims to provide a reference for future novel prevention and treatment strategies for neurodegenerative diseases.
DOI: 10.3969/j.issn.1672-6731.2018.03.010 |
topic |
Uric acid Parkinson disease Alzheimer disease Amyotrophic lateral sclerosis Multiple system atrophy Review |
url |
http://www.cjcnn.org/index.php/cjcnn/article/view/1752 |
work_keys_str_mv |
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1725486587232387072 |