Effects of Acupuncture on 1-Chloro-2,4-dinitrochlorobenzene-Induced Atopic Dermatitis
Though the effects of acupuncture in atopic dermatitis have been proven in clinical studies, its mechanism remains unclear. In this study, we investigate the effectiveness and mechanism of action for acupuncture treatment on the LI11 meridian point for treatment of allergic contact dermatitis. BALB/...
Main Authors: | , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Hindawi Limited
2013-01-01
|
Series: | Evidence-Based Complementary and Alternative Medicine |
Online Access: | http://dx.doi.org/10.1155/2013/982095 |
id |
doaj-134e299b36fb457da41d2acf1782342d |
---|---|
record_format |
Article |
spelling |
doaj-134e299b36fb457da41d2acf1782342d2020-11-24T23:11:34ZengHindawi LimitedEvidence-Based Complementary and Alternative Medicine1741-427X1741-42882013-01-01201310.1155/2013/982095982095Effects of Acupuncture on 1-Chloro-2,4-dinitrochlorobenzene-Induced Atopic DermatitisJi-Yeun Park0Hi-Joon Park1You Yeon Choi2Mi Hye Kim3Seung-Nam Kim4Woong Mo Yang5Studies of Translational Acupuncture Research (STAR), Acupuncture and Meridian Science Research Center (AMSRC), Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 130-701, Republic of KoreaStudies of Translational Acupuncture Research (STAR), Acupuncture and Meridian Science Research Center (AMSRC), Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 130-701, Republic of KoreaDepartment of Prescriptionology, College of Korean Medicine, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 130-701, Republic of KoreaDepartment of Prescriptionology, College of Korean Medicine, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 130-701, Republic of KoreaStudies of Translational Acupuncture Research (STAR), Acupuncture and Meridian Science Research Center (AMSRC), Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 130-701, Republic of KoreaDepartment of Prescriptionology, College of Korean Medicine, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 130-701, Republic of KoreaThough the effects of acupuncture in atopic dermatitis have been proven in clinical studies, its mechanism remains unclear. In this study, we investigate the effectiveness and mechanism of action for acupuncture treatment on the LI11 meridian point for treatment of allergic contact dermatitis. BALB/c mice received 1-chloro-2,4-dinitrobenzene (DNCB) application to induce skin inflammation. Acupuncture treatment on LI11 significantly inhibited cutaneous hyperplasia, serum IgE levels, and expression of proinflammatory cytokine (IL-4, IL-8, and TNF-α) mRNA and NF-κB, ERK1/2, JNK, and p38 proteins. Acupuncture treatment of local points also inhibited cutaneous hyperplasia and serum IgE levels; however, it was not effective in regulating proinflammatory cytokines and proteins. In addition, LI11 treatment is more effective at reducing serum IgE levels and pro-inflammatory cytokines and proteins than local point treatment. These results suggest that acupuncture treatment is effective in alleviating allergic contact dermatitis by reducing pro-inflammatory cytokines and proteins.http://dx.doi.org/10.1155/2013/982095 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ji-Yeun Park Hi-Joon Park You Yeon Choi Mi Hye Kim Seung-Nam Kim Woong Mo Yang |
spellingShingle |
Ji-Yeun Park Hi-Joon Park You Yeon Choi Mi Hye Kim Seung-Nam Kim Woong Mo Yang Effects of Acupuncture on 1-Chloro-2,4-dinitrochlorobenzene-Induced Atopic Dermatitis Evidence-Based Complementary and Alternative Medicine |
author_facet |
Ji-Yeun Park Hi-Joon Park You Yeon Choi Mi Hye Kim Seung-Nam Kim Woong Mo Yang |
author_sort |
Ji-Yeun Park |
title |
Effects of Acupuncture on 1-Chloro-2,4-dinitrochlorobenzene-Induced Atopic Dermatitis |
title_short |
Effects of Acupuncture on 1-Chloro-2,4-dinitrochlorobenzene-Induced Atopic Dermatitis |
title_full |
Effects of Acupuncture on 1-Chloro-2,4-dinitrochlorobenzene-Induced Atopic Dermatitis |
title_fullStr |
Effects of Acupuncture on 1-Chloro-2,4-dinitrochlorobenzene-Induced Atopic Dermatitis |
title_full_unstemmed |
Effects of Acupuncture on 1-Chloro-2,4-dinitrochlorobenzene-Induced Atopic Dermatitis |
title_sort |
effects of acupuncture on 1-chloro-2,4-dinitrochlorobenzene-induced atopic dermatitis |
publisher |
Hindawi Limited |
series |
Evidence-Based Complementary and Alternative Medicine |
issn |
1741-427X 1741-4288 |
publishDate |
2013-01-01 |
description |
Though the effects of acupuncture in atopic dermatitis have been proven in clinical studies, its mechanism remains unclear. In this study, we investigate the effectiveness and mechanism of action for acupuncture treatment on the LI11 meridian point for treatment of allergic contact dermatitis. BALB/c mice received 1-chloro-2,4-dinitrobenzene (DNCB) application to induce skin inflammation. Acupuncture treatment on LI11 significantly inhibited cutaneous hyperplasia, serum IgE levels, and expression of proinflammatory cytokine (IL-4, IL-8, and TNF-α) mRNA and NF-κB, ERK1/2, JNK, and p38 proteins. Acupuncture treatment of local points also inhibited cutaneous hyperplasia and serum IgE levels; however, it was not effective in regulating proinflammatory cytokines and proteins. In addition, LI11 treatment is more effective at reducing serum IgE levels and pro-inflammatory cytokines and proteins than local point treatment. These results suggest that acupuncture treatment is effective in alleviating allergic contact dermatitis by reducing pro-inflammatory cytokines and proteins. |
url |
http://dx.doi.org/10.1155/2013/982095 |
work_keys_str_mv |
AT jiyeunpark effectsofacupunctureon1chloro24dinitrochlorobenzeneinducedatopicdermatitis AT hijoonpark effectsofacupunctureon1chloro24dinitrochlorobenzeneinducedatopicdermatitis AT youyeonchoi effectsofacupunctureon1chloro24dinitrochlorobenzeneinducedatopicdermatitis AT mihyekim effectsofacupunctureon1chloro24dinitrochlorobenzeneinducedatopicdermatitis AT seungnamkim effectsofacupunctureon1chloro24dinitrochlorobenzeneinducedatopicdermatitis AT woongmoyang effectsofacupunctureon1chloro24dinitrochlorobenzeneinducedatopicdermatitis |
_version_ |
1725603800197103616 |