HLA-DRB1 as a risk factor in children with autoimmune hepatitis and its relation to hepatitis A infection
<p>Abstract</p> <p>Background</p> <p>The human leukocyte antigens (HLAs) are proteins found in the membranes of nearly all nucleated cells. People with certain HLA antigens are more likely to develop certain autoimmune diseases. The aim of this study was to determine th...
Main Authors: | , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
BMC
2010-11-01
|
Series: | Italian Journal of Pediatrics |
Online Access: | http://www.ijponline.net/content/36/1/73 |
id |
doaj-1361c50e856442548a382672986aace6 |
---|---|
record_format |
Article |
spelling |
doaj-1361c50e856442548a382672986aace62020-11-24T21:20:19ZengBMCItalian Journal of Pediatrics1720-84241824-72882010-11-013617310.1186/1824-7288-36-73HLA-DRB1 as a risk factor in children with autoimmune hepatitis and its relation to hepatitis A infectionAbbas Amal AElhossiny Reham MElfaramawy Amel AMAziz Heba<p>Abstract</p> <p>Background</p> <p>The human leukocyte antigens (HLAs) are proteins found in the membranes of nearly all nucleated cells. People with certain HLA antigens are more likely to develop certain autoimmune diseases. The aim of this study was to determine the frequency of HLA-DRB1 in children with autoimmune hepatitis (AIH) as a risk factor for occurrence, its relation to preceding hepatitis A infection and treatment outcome.</p> <p>Subjects and methods</p> <p>25 children with AIH were subjected to HLA-DRB 1 typing performed by sequence specific oligonucleotide probe technique and compared to HLA-DRB1 found in 548 normal populations.</p> <p>Results</p> <p>The most frequent alleles found in our children with AIH were HLA-DRB1*13 (36%), HLA-DRB1*04 (18%) and HLA-DRB1*03 (14%). HLA-DRB1*13 was significantly more frequent in AIH patients compared to controls. In type I AIH patients HLA-DRB1*13 was the most frequent allele (32.4%), followed by HLA-DRB1*04 in (20.6%) and HLA-DRB1*03 in (14.7%), While in type II, the most frequent alleles were HLA-DRB1*13 in (40%), HLA-DRB1*07 (20%) and HLA-DRB1*15 in (20%). HLA-DRB1*12 was significantly more frequent in AIH patients with positive Hepatitis A IgM than in patients with negative hepatitis A IgM. No statistically significant difference between partial responders and complete responders to treatment as regards HLA-DRB1 subtypes.</p> <p>Conclusion</p> <p>It is concluded from the previous study that HLA-DRB1*13 may be a susceptibility allele for the occurrence of autoimmune hepatitis in our population. HLA-DRB1*07 and HLA-DRB1*15 may be susceptibility alleles for occurrence of autoimmune hepatitis type 2. HLA-DRB1*12 association with AIH in patients triggered by hepatitis A needs further studies.</p> http://www.ijponline.net/content/36/1/73 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Abbas Amal A Elhossiny Reham M Elfaramawy Amel AM Aziz Heba |
spellingShingle |
Abbas Amal A Elhossiny Reham M Elfaramawy Amel AM Aziz Heba HLA-DRB1 as a risk factor in children with autoimmune hepatitis and its relation to hepatitis A infection Italian Journal of Pediatrics |
author_facet |
Abbas Amal A Elhossiny Reham M Elfaramawy Amel AM Aziz Heba |
author_sort |
Abbas Amal A |
title |
HLA-DRB1 as a risk factor in children with autoimmune hepatitis and its relation to hepatitis A infection |
title_short |
HLA-DRB1 as a risk factor in children with autoimmune hepatitis and its relation to hepatitis A infection |
title_full |
HLA-DRB1 as a risk factor in children with autoimmune hepatitis and its relation to hepatitis A infection |
title_fullStr |
HLA-DRB1 as a risk factor in children with autoimmune hepatitis and its relation to hepatitis A infection |
title_full_unstemmed |
HLA-DRB1 as a risk factor in children with autoimmune hepatitis and its relation to hepatitis A infection |
title_sort |
hla-drb1 as a risk factor in children with autoimmune hepatitis and its relation to hepatitis a infection |
publisher |
BMC |
series |
Italian Journal of Pediatrics |
issn |
1720-8424 1824-7288 |
publishDate |
2010-11-01 |
description |
<p>Abstract</p> <p>Background</p> <p>The human leukocyte antigens (HLAs) are proteins found in the membranes of nearly all nucleated cells. People with certain HLA antigens are more likely to develop certain autoimmune diseases. The aim of this study was to determine the frequency of HLA-DRB1 in children with autoimmune hepatitis (AIH) as a risk factor for occurrence, its relation to preceding hepatitis A infection and treatment outcome.</p> <p>Subjects and methods</p> <p>25 children with AIH were subjected to HLA-DRB 1 typing performed by sequence specific oligonucleotide probe technique and compared to HLA-DRB1 found in 548 normal populations.</p> <p>Results</p> <p>The most frequent alleles found in our children with AIH were HLA-DRB1*13 (36%), HLA-DRB1*04 (18%) and HLA-DRB1*03 (14%). HLA-DRB1*13 was significantly more frequent in AIH patients compared to controls. In type I AIH patients HLA-DRB1*13 was the most frequent allele (32.4%), followed by HLA-DRB1*04 in (20.6%) and HLA-DRB1*03 in (14.7%), While in type II, the most frequent alleles were HLA-DRB1*13 in (40%), HLA-DRB1*07 (20%) and HLA-DRB1*15 in (20%). HLA-DRB1*12 was significantly more frequent in AIH patients with positive Hepatitis A IgM than in patients with negative hepatitis A IgM. No statistically significant difference between partial responders and complete responders to treatment as regards HLA-DRB1 subtypes.</p> <p>Conclusion</p> <p>It is concluded from the previous study that HLA-DRB1*13 may be a susceptibility allele for the occurrence of autoimmune hepatitis in our population. HLA-DRB1*07 and HLA-DRB1*15 may be susceptibility alleles for occurrence of autoimmune hepatitis type 2. HLA-DRB1*12 association with AIH in patients triggered by hepatitis A needs further studies.</p> |
url |
http://www.ijponline.net/content/36/1/73 |
work_keys_str_mv |
AT abbasamala hladrb1asariskfactorinchildrenwithautoimmunehepatitisanditsrelationtohepatitisainfection AT elhossinyrehamm hladrb1asariskfactorinchildrenwithautoimmunehepatitisanditsrelationtohepatitisainfection AT elfaramawyamelam hladrb1asariskfactorinchildrenwithautoimmunehepatitisanditsrelationtohepatitisainfection AT azizheba hladrb1asariskfactorinchildrenwithautoimmunehepatitisanditsrelationtohepatitisainfection |
_version_ |
1726002792685895680 |