Radiologic Complete Response In Lung Adenocarcinoma With Symptomatic Brain Metastasis After Systematic Therapy: A Case Study

Jianxin Chen,1 Junhui Wang,2 Qinhong Zheng,1 Meiling Weng,1 Xilin Wu1 1Department of Medical Oncology, Quzhou People’s Hospital, Quzhou, Zhejiang 324000, People’s Republic of China; 2Department of Radiation Oncology, Quzhou People’s Hospital, Quzhou, Zhejiang 324000, Pe...

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Main Authors: Chen J, Wang J, Zheng Q, Weng M, Wu X
Format: Article
Language:English
Published: Dove Medical Press 2019-11-01
Series:OncoTargets and Therapy
Subjects:
Online Access:https://www.dovepress.com/radiologic-complete-response-in-lung-adenocarcinoma-with-symptomatic-b-peer-reviewed-article-OTT
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spelling doaj-136d1069a3a7476e8528154909d72f492020-11-25T01:33:52ZengDove Medical PressOncoTargets and Therapy1178-69302019-11-01Volume 129551955749677Radiologic Complete Response In Lung Adenocarcinoma With Symptomatic Brain Metastasis After Systematic Therapy: A Case StudyChen JWang JZheng QWeng MWu XJianxin Chen,1 Junhui Wang,2 Qinhong Zheng,1 Meiling Weng,1 Xilin Wu1 1Department of Medical Oncology, Quzhou People’s Hospital, Quzhou, Zhejiang 324000, People’s Republic of China; 2Department of Radiation Oncology, Quzhou People’s Hospital, Quzhou, Zhejiang 324000, People’s Republic of ChinaCorrespondence: Xilin WuDepartment of Medical Oncology, Quzhou People’s Hospital, Quzhou, Zhejiang 324000, People’s Republic of ChinaEmail wuxilin1544@163.comAbstract: Patients diagnosed as lung adenocarcinoma with brain metastasis usually result in poor prognosis with limited survival time. Palliative systematic therapy has emerged as the primary choice for non-small cell lung cancer patients with brain metastasis harboring wild-type drive genes. However, the objective response rate and long-term survival for patients treated with this therapy remained unsatisfied. Herein, we present a case with lung adenocarcinoma accompanied with symptomatic brain metastasis who achieved radiologic complete response after receiving combined therapy including stereotactic body radiation therapy, anti-angiogenesis, and chemotherapy. He has achieved a duration of disease-free survival of thirty-six months, and is still in extension.Keywords: complete response, lung adenocarcinoma, brain metastasis, systematic therapyhttps://www.dovepress.com/radiologic-complete-response-in-lung-adenocarcinoma-with-symptomatic-b-peer-reviewed-article-OTTcomplete responselung adenocarcinomabrain metastasissystematic therapy
collection DOAJ
language English
format Article
sources DOAJ
author Chen J
Wang J
Zheng Q
Weng M
Wu X
spellingShingle Chen J
Wang J
Zheng Q
Weng M
Wu X
Radiologic Complete Response In Lung Adenocarcinoma With Symptomatic Brain Metastasis After Systematic Therapy: A Case Study
OncoTargets and Therapy
complete response
lung adenocarcinoma
brain metastasis
systematic therapy
author_facet Chen J
Wang J
Zheng Q
Weng M
Wu X
author_sort Chen J
title Radiologic Complete Response In Lung Adenocarcinoma With Symptomatic Brain Metastasis After Systematic Therapy: A Case Study
title_short Radiologic Complete Response In Lung Adenocarcinoma With Symptomatic Brain Metastasis After Systematic Therapy: A Case Study
title_full Radiologic Complete Response In Lung Adenocarcinoma With Symptomatic Brain Metastasis After Systematic Therapy: A Case Study
title_fullStr Radiologic Complete Response In Lung Adenocarcinoma With Symptomatic Brain Metastasis After Systematic Therapy: A Case Study
title_full_unstemmed Radiologic Complete Response In Lung Adenocarcinoma With Symptomatic Brain Metastasis After Systematic Therapy: A Case Study
title_sort radiologic complete response in lung adenocarcinoma with symptomatic brain metastasis after systematic therapy: a case study
publisher Dove Medical Press
series OncoTargets and Therapy
issn 1178-6930
publishDate 2019-11-01
description Jianxin Chen,1 Junhui Wang,2 Qinhong Zheng,1 Meiling Weng,1 Xilin Wu1 1Department of Medical Oncology, Quzhou People’s Hospital, Quzhou, Zhejiang 324000, People’s Republic of China; 2Department of Radiation Oncology, Quzhou People’s Hospital, Quzhou, Zhejiang 324000, People’s Republic of ChinaCorrespondence: Xilin WuDepartment of Medical Oncology, Quzhou People’s Hospital, Quzhou, Zhejiang 324000, People’s Republic of ChinaEmail wuxilin1544@163.comAbstract: Patients diagnosed as lung adenocarcinoma with brain metastasis usually result in poor prognosis with limited survival time. Palliative systematic therapy has emerged as the primary choice for non-small cell lung cancer patients with brain metastasis harboring wild-type drive genes. However, the objective response rate and long-term survival for patients treated with this therapy remained unsatisfied. Herein, we present a case with lung adenocarcinoma accompanied with symptomatic brain metastasis who achieved radiologic complete response after receiving combined therapy including stereotactic body radiation therapy, anti-angiogenesis, and chemotherapy. He has achieved a duration of disease-free survival of thirty-six months, and is still in extension.Keywords: complete response, lung adenocarcinoma, brain metastasis, systematic therapy
topic complete response
lung adenocarcinoma
brain metastasis
systematic therapy
url https://www.dovepress.com/radiologic-complete-response-in-lung-adenocarcinoma-with-symptomatic-b-peer-reviewed-article-OTT
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