Summary: | Two new sesquiterpenoids belonging to the guaiane, 4α,9α,10α-trihydroxyguaia-11(13)en-12,6α-olide (<b>1</b>), and germacrane, 9β-hydroxyparthenolide-9-<i>O</i>-β-D-glucopyranoside (<b>2</b>), classes have been isolated from the leaves of the Saudi medicinal plant <i>Anvillea garcinii</i> along with seven known compounds (<b>3</b>–<b>9</b>). The structures of the new metabolites were elucidated by spectroscopic analysis, including one-dimensional (1D) and two-dimensional (2D) Nuclear Magnetic Resonance (NMR) and high-resolution electrospray ionization mass spectrometry (HR-ESIMS). The antimicrobial properties of <b>1</b>–<b>9</b> were screened against seven different pathogenic microbes, and compounds <b>1</b>–<b>3</b> showed a potent antifungal activity.
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