The C60-Fullerene Porphyrin Adducts for Prevention of the Doxorubicin-Induced Acute Cardiotoxicity in Rat Myocardial Cells

• Main Authors: Seyed Vahid Shetab Boushehri, Seyed Nasser Ostad, Saeed Sarkar, Dmitry A. Kuznetsov, Anatoly L. Buchachenko, Marina A. Orlova, Bagher Minaii, Abbas Kebriaeezadeh, Seyed Mahdi Rezayat
• Format: Article
• Language: English
• Published: Tehran University of Medical Sciences 2010-10-01
• Series: Acta Medica Iranica
• Subjects: Fullerene nanoparticles; doxorubicin-induced cardiotoxicity; 25Mg2; mitochondrial dysfunctions.
• Online Access: https://acta.tums.ac.ir/index.php/acta/article/view/4061

This is a fullerene-based low toxic nanocationite designed for targeted delivery of the paramagnetic stable isotope of magnesium to the doxorubicin (DXR)-induced damaged heart muscle providing a prominent effect close to about 80% recovery of the tissue hypoxia symptoms in less than 24 hrs after a single injection (0.03 - 0.1 LD50). Magnesium magnetic isotope effect selectively stimulates the ATP formation in the oxygen-depleted cells due to a creatine kinase (CK) and mitochondrial respiratory chain-focusing "attack" of 25Mg2+ released by nanoparticles. These "smart nanoparticles" with membranotropic properties release the overactivating cations only in response to the intracellular acidosis. The resulting positive changes in the energy metabolism of heart cell may help to prevent local myocardial hypoxic (ischemic) disorders and, hence, to protect the heart muscle from a serious damage in a vast variety of the hypoxia-induced clinical situations including DXR side effects.