Membrane-Associated Flavivirus Replication Complex—Its Organization and Regulation

Membrane-Associated Flavivirus Replication Complex—Its Organization and Regulation

Flavivirus consists of a large number of arthropod-borne viruses, many of which cause life-threatening diseases in humans. A characteristic feature of flavivirus infection is to induce the rearrangement of intracellular membrane structure in the cytoplasm. This unique membranous structure called rep...

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Main Authors: Eiji Morita, Youichi Suzuki
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Viruses
Subjects:
flavivirus
replication complex
replication organelle
endoplasmic reticulum
membranous microenvironment
cellular factors
Online Access:https://www.mdpi.com/1999-4915/13/6/1060
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spelling doaj-137c22d276f545669f20ec710fba44822021-06-30T23:13:11ZengMDPI AGViruses1999-49152021-06-01131060106010.3390/v13061060Membrane-Associated Flavivirus Replication Complex—Its Organization and RegulationEiji Morita0Youichi Suzuki1Department of Biochemistry and Molecular Biology, Faculty of Agriculture and Life Science, Hirosaki University, 3 Bunkyo-cho, Hirosaki-shi 036-8561, JapanDepartment of Microbiology and Infection Control, Faculty of Medicine, Osaka Medical and Pharmaceutical University, 2-7 Daigaku-machi, Takatsuki 569-8686, JapanFlavivirus consists of a large number of arthropod-borne viruses, many of which cause life-threatening diseases in humans. A characteristic feature of flavivirus infection is to induce the rearrangement of intracellular membrane structure in the cytoplasm. This unique membranous structure called replication organelle is considered as a microenvironment that provides factors required for the activity of the flaviviral replication complex. The replication organelle serves as a place to coordinate viral RNA amplification, protein translation, and virion assembly and also to protect the viral replication complex from the cellular immune defense system. In this review, we summarize the current understanding of how the formation and function of membrane-associated flaviviral replication organelle are regulated by cellular factors.https://www.mdpi.com/1999-4915/13/6/1060flavivirusreplication complexreplication organelleendoplasmic reticulummembranous microenvironmentcellular factors
collection DOAJ
language English
format Article
sources DOAJ
author Eiji Morita
Youichi Suzuki
spellingShingle Eiji Morita
Youichi Suzuki
Membrane-Associated Flavivirus Replication Complex—Its Organization and Regulation
Viruses
flavivirus
replication complex
replication organelle
endoplasmic reticulum
membranous microenvironment
cellular factors
author_facet Eiji Morita
Youichi Suzuki
author_sort Eiji Morita
title Membrane-Associated Flavivirus Replication Complex—Its Organization and Regulation
title_short Membrane-Associated Flavivirus Replication Complex—Its Organization and Regulation
title_full Membrane-Associated Flavivirus Replication Complex—Its Organization and Regulation
title_fullStr Membrane-Associated Flavivirus Replication Complex—Its Organization and Regulation
title_full_unstemmed Membrane-Associated Flavivirus Replication Complex—Its Organization and Regulation
title_sort membrane-associated flavivirus replication complex—its organization and regulation
publisher MDPI AG
series Viruses
issn 1999-4915
publishDate 2021-06-01
description Flavivirus consists of a large number of arthropod-borne viruses, many of which cause life-threatening diseases in humans. A characteristic feature of flavivirus infection is to induce the rearrangement of intracellular membrane structure in the cytoplasm. This unique membranous structure called replication organelle is considered as a microenvironment that provides factors required for the activity of the flaviviral replication complex. The replication organelle serves as a place to coordinate viral RNA amplification, protein translation, and virion assembly and also to protect the viral replication complex from the cellular immune defense system. In this review, we summarize the current understanding of how the formation and function of membrane-associated flaviviral replication organelle are regulated by cellular factors.
topic flavivirus
replication complex
replication organelle
endoplasmic reticulum
membranous microenvironment
cellular factors
url https://www.mdpi.com/1999-4915/13/6/1060
work_keys_str_mv AT eijimorita membraneassociatedflavivirusreplicationcomplexitsorganizationandregulation
AT youichisuzuki membraneassociatedflavivirusreplicationcomplexitsorganizationandregulation
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