PDE9 Inhibitor PF-04447943 Attenuates DSS-Induced Colitis by Suppressing Oxidative Stress, Inflammation, and Regulating T-Cell Polarization

PDE9 Inhibitor PF-04447943 Attenuates DSS-Induced Colitis by Suppressing Oxidative Stress, Inflammation, and Regulating T-Cell Polarization

Ulcerative colitis (UC) is a form of inflammatory bowel disease, which manifests as irritation or swelling and sores in the large intestine in a relapsing and remitting manner. In a dextran sulfate sodium sulfate (DSS)-induced UC model in female mice, we found that the levels of cyclic guanosine mon...

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Bibliographic Details
Main Authors: Mohammad Nasiruddin Rana, Jie Lu, Enfu Xue, Jingjing Ruan, Yuting Liu, Lejun Zhang, Rana Dhar, Yajun Li, Zhengqiang Hu, Jie Zhou, Wangqian Ma, Huifang Tang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Pharmacology
Subjects:
ulcerative colitis
PF-04447943
inflammasome
Treg/Th17 cell balance
PDE9A
oxidative stress
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.643215/full

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https://www.frontiersin.org/articles/10.3389/fphar.2021.643215/full

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