PDE9 Inhibitor PF-04447943 Attenuates DSS-Induced Colitis by Suppressing Oxidative Stress, Inflammation, and Regulating T-Cell Polarization
Ulcerative colitis (UC) is a form of inflammatory bowel disease, which manifests as irritation or swelling and sores in the large intestine in a relapsing and remitting manner. In a dextran sulfate sodium sulfate (DSS)-induced UC model in female mice, we found that the levels of cyclic guanosine mon...
Main Authors: | Mohammad Nasiruddin Rana, Jie Lu, Enfu Xue, Jingjing Ruan, Yuting Liu, Lejun Zhang, Rana Dhar, Yajun Li, Zhengqiang Hu, Jie Zhou, Wangqian Ma, Huifang Tang |
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Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2021-04-01
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Series: | Frontiers in Pharmacology |
Subjects: | |
Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2021.643215/full |
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