TLR4 Signaling Pathway Modulators as Potential Therapeutics in Inflammation and Sepsis

TLR4 Signaling Pathway Modulators as Potential Therapeutics in Inflammation and Sepsis

Toll-Like Receptor 4 (TLR4) signal pathway plays an important role in initiating the innate immune response and its activation by bacterial endotoxin is responsible for chronic and acute inflammatory disorders that are becoming more and more frequent in developed countries. Modulation of the TLR4 pa...

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Bibliographic Details
Main Authors: Nikolay N. Kuzmich, Konstantin V. Sivak, Vladimir N. Chubarev, Yuri B. Porozov, Tatiana N. Savateeva-Lyubimova, Francesco Peri
Format: Article
Language:English
Published: MDPI AG 2017-10-01
Series:Vaccines
Subjects:
TLR4
sepsis
LPS
CD14
MD-2
in vivo studies
PAMP
DAMP
Online Access:https://www.mdpi.com/2076-393X/5/4/34

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