Lovastatin suppresses bacterial therapy-induced neutrophil recruitment to the tumor by promoting neutrophil apoptosis

Lovastatin is a statin produced by Monascus purpureous-fermented pu-erh tea, which is used in the treatment of cardiovascular diseases and prostate cancer. Bacteria-mediated cancer immunotherapy (BCI), which is an effective antitumor strategy compared with conventional immunotherapies, targets neutr...

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Main Authors:	Hong Zhang, Shaoting Sang, Huimin Xu, Linghua Piao, Xiande Liu
Format:	Article
Language:	English
Published:	Elsevier 2021-11-01
Series:	Journal of Functional Foods
Subjects:	Bacteria-mediated cancer immunotherapy Lovastatin Neutrophils ERK AKT
Online Access:	http://www.sciencedirect.com/science/article/pii/S175646462100342X

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spelling	doaj-139b496c34b64a9a8696f34b5c84a86a2021-09-05T04:40:05ZengElsevierJournal of Functional Foods1756-46462021-11-0186104693Lovastatin suppresses bacterial therapy-induced neutrophil recruitment to the tumor by promoting neutrophil apoptosisHong Zhang0Shaoting Sang1Huimin Xu2Linghua Piao3Xiande Liu4College of Animal Science and Technology, Hainan University, Haikou, ChinaSchool of Life and Pharmaceutical Sciences, Hainan University, Haikou, ChinaSchool of Life and Pharmaceutical Sciences, Hainan University, Haikou, ChinaDepartment of Physiology, Hainan Medical University, Haikou, China; Corresponding authors at: School of Life and Pharmaceutical Sciences, Hainan University, No. 58 Renmin Avenue, Haikou 570228, China (X. Liu). Department of Physiology, Hainan Medical University, No. 3 Xueyuan Avenue, Haikou 571199, China (L. Piao).School of Life and Pharmaceutical Sciences, Hainan University, Haikou, China; Corresponding authors at: School of Life and Pharmaceutical Sciences, Hainan University, No. 58 Renmin Avenue, Haikou 570228, China (X. Liu). Department of Physiology, Hainan Medical University, No. 3 Xueyuan Avenue, Haikou 571199, China (L. Piao).Lovastatin is a statin produced by Monascus purpureous-fermented pu-erh tea, which is used in the treatment of cardiovascular diseases and prostate cancer. Bacteria-mediated cancer immunotherapy (BCI), which is an effective antitumor strategy compared with conventional immunotherapies, targets neutrophil infiltration associated with tumor recurrence and metastasis. In mouse colon cancer models, combination treatment with lovastatin and BCI suppressed tumor progression by extending the survival of tumor-colonizing bacteria. We used zebrafish live imaging to show that lovastatin decreases the recruitment of neutrophils to the inflammatory site by inducing neutrophil apoptosis via phosphorylation of ERK and AKT. The present findings suggest that the combination of BCI with lovastatin or fermented pu-erh tea is an effective approach compared with conventional cancer immunotherapy.http://www.sciencedirect.com/science/article/pii/S175646462100342XBacteria-mediated cancer immunotherapyLovastatinNeutrophilsERKAKT
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Hong Zhang Shaoting Sang Huimin Xu Linghua Piao Xiande Liu
spellingShingle	Hong Zhang Shaoting Sang Huimin Xu Linghua Piao Xiande Liu Lovastatin suppresses bacterial therapy-induced neutrophil recruitment to the tumor by promoting neutrophil apoptosis Journal of Functional Foods Bacteria-mediated cancer immunotherapy Lovastatin Neutrophils ERK AKT
author_facet	Hong Zhang Shaoting Sang Huimin Xu Linghua Piao Xiande Liu
author_sort	Hong Zhang
title	Lovastatin suppresses bacterial therapy-induced neutrophil recruitment to the tumor by promoting neutrophil apoptosis
title_short	Lovastatin suppresses bacterial therapy-induced neutrophil recruitment to the tumor by promoting neutrophil apoptosis
title_full	Lovastatin suppresses bacterial therapy-induced neutrophil recruitment to the tumor by promoting neutrophil apoptosis
title_fullStr	Lovastatin suppresses bacterial therapy-induced neutrophil recruitment to the tumor by promoting neutrophil apoptosis
title_full_unstemmed	Lovastatin suppresses bacterial therapy-induced neutrophil recruitment to the tumor by promoting neutrophil apoptosis
title_sort	lovastatin suppresses bacterial therapy-induced neutrophil recruitment to the tumor by promoting neutrophil apoptosis
publisher	Elsevier
series	Journal of Functional Foods
issn	1756-4646
publishDate	2021-11-01
description	Lovastatin is a statin produced by Monascus purpureous-fermented pu-erh tea, which is used in the treatment of cardiovascular diseases and prostate cancer. Bacteria-mediated cancer immunotherapy (BCI), which is an effective antitumor strategy compared with conventional immunotherapies, targets neutrophil infiltration associated with tumor recurrence and metastasis. In mouse colon cancer models, combination treatment with lovastatin and BCI suppressed tumor progression by extending the survival of tumor-colonizing bacteria. We used zebrafish live imaging to show that lovastatin decreases the recruitment of neutrophils to the inflammatory site by inducing neutrophil apoptosis via phosphorylation of ERK and AKT. The present findings suggest that the combination of BCI with lovastatin or fermented pu-erh tea is an effective approach compared with conventional cancer immunotherapy.
topic	Bacteria-mediated cancer immunotherapy Lovastatin Neutrophils ERK AKT
url	http://www.sciencedirect.com/science/article/pii/S175646462100342X
work_keys_str_mv	AT hongzhang lovastatinsuppressesbacterialtherapyinducedneutrophilrecruitmenttothetumorbypromotingneutrophilapoptosis AT shaotingsang lovastatinsuppressesbacterialtherapyinducedneutrophilrecruitmenttothetumorbypromotingneutrophilapoptosis AT huiminxu lovastatinsuppressesbacterialtherapyinducedneutrophilrecruitmenttothetumorbypromotingneutrophilapoptosis AT linghuapiao lovastatinsuppressesbacterialtherapyinducedneutrophilrecruitmenttothetumorbypromotingneutrophilapoptosis AT xiandeliu lovastatinsuppressesbacterialtherapyinducedneutrophilrecruitmenttothetumorbypromotingneutrophilapoptosis
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Lovastatin suppresses bacterial therapy-induced neutrophil recruitment to the tumor by promoting neutrophil apoptosis

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