Antihypertensive effect of Korean Red Ginseng by enrichment of ginsenoside Rg3 and arginine–fructose
Background: Ginsenoside Rg3 and arginine–fructose (Arg-Fru) are known as the hypotensive compounds of Panax ginseng; however, their efficacy on antihypertension has not been reported yet to our best knowledge. Thus, hypotensive components-enriched fraction of red ginseng (HCEF-RG) was prepared from...
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doaj-139ba13dcf20458ea68abfcbe0f5c51d2020-11-25T00:00:48ZengElsevierJournal of Ginseng Research1226-84532016-07-0140323724410.1016/j.jgr.2015.08.002Antihypertensive effect of Korean Red Ginseng by enrichment of ginsenoside Rg3 and arginine–fructoseKyung Hee Lee0In Young Bae1Song I. Park2Jong-Dae Park3Hyeon Gyu Lee4Department of Food and Nutrition, Hanyang University, Seoul, KoreaDepartment of Food and Fermentation, Far East University, Eumseong, KoreaDepartment of Food and Nutrition, Hanyang University, Seoul, KoreaDepartment of Food and Nutrition, Hanyang University, Seoul, KoreaDepartment of Food and Nutrition, Hanyang University, Seoul, KoreaBackground: Ginsenoside Rg3 and arginine–fructose (Arg-Fru) are known as the hypotensive compounds of Panax ginseng; however, their efficacy on antihypertension has not been reported yet to our best knowledge. Thus, hypotensive components-enriched fraction of red ginseng (HCEF-RG) was prepared from fine root concentrate (FR) and their antihypertensive effects were investigated in spontaneously hypertensive rats (SHR). Methods: Male SHRs were divided into six groups: control (Wistar Kyoto, SHR); FR 500; FR 1,000; HCEF-RG 500; and HCEF-RG 1,000; samples (mg/kg body weight) were orally administered every day for 8 wk. Blood pressure was monitored at 1 wk, 2 wk, 3 wk, 4 wk, 6 wk, and 8 wk by tail cuff method. At 8 wk after samples administration, mice were killed for the measurement of renin activity (RA), angiotensin-I converting enzyme inhibition, angiotensin II, and nitric oxide (NO) levels in plasma. Results: HCEF-RG with four-fold more Rg3 and 24-fold more Arg-Fru contents was successfully prepared from reacted mixtures of FR and persimmon vinegar (12 times against FR, v/v) at 80°C for 18 h. Both FR 1,000 and HCEF-RG 1,000 showed lowered systolic blood pressure than SHR control group and HCEF-RG 1,000 group exhibited a significant decrease in diastolic blood pressure. RA was significantly lowered in all treated groups, while angiotensin II did not affect by FR and HCEF-RG treatment. However, angiotensin-I converting enzyme inhibition and NO in FR 1,000 and HCEF-RG 1,000 were significantly increased compared with SHR control group. Conclusion: HCEF-RG is more effective and useful for alleviating hypertension than FR, implying the health benefit of Rg3 and Arg-Fru.http://www.sciencedirect.com/science/article/pii/S1226845315000779arginine–fructoseblood pressureginsenoside Rg3hypotensive components-enrichedKorean Red Ginseng |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kyung Hee Lee In Young Bae Song I. Park Jong-Dae Park Hyeon Gyu Lee |
spellingShingle |
Kyung Hee Lee In Young Bae Song I. Park Jong-Dae Park Hyeon Gyu Lee Antihypertensive effect of Korean Red Ginseng by enrichment of ginsenoside Rg3 and arginine–fructose Journal of Ginseng Research arginine–fructose blood pressure ginsenoside Rg3 hypotensive components-enriched Korean Red Ginseng |
author_facet |
Kyung Hee Lee In Young Bae Song I. Park Jong-Dae Park Hyeon Gyu Lee |
author_sort |
Kyung Hee Lee |
title |
Antihypertensive effect of Korean Red Ginseng by enrichment of ginsenoside Rg3 and arginine–fructose |
title_short |
Antihypertensive effect of Korean Red Ginseng by enrichment of ginsenoside Rg3 and arginine–fructose |
title_full |
Antihypertensive effect of Korean Red Ginseng by enrichment of ginsenoside Rg3 and arginine–fructose |
title_fullStr |
Antihypertensive effect of Korean Red Ginseng by enrichment of ginsenoside Rg3 and arginine–fructose |
title_full_unstemmed |
Antihypertensive effect of Korean Red Ginseng by enrichment of ginsenoside Rg3 and arginine–fructose |
title_sort |
antihypertensive effect of korean red ginseng by enrichment of ginsenoside rg3 and arginine–fructose |
publisher |
Elsevier |
series |
Journal of Ginseng Research |
issn |
1226-8453 |
publishDate |
2016-07-01 |
description |
Background: Ginsenoside Rg3 and arginine–fructose (Arg-Fru) are known as the hypotensive compounds of Panax ginseng; however, their efficacy on antihypertension has not been reported yet to our best knowledge. Thus, hypotensive components-enriched fraction of red ginseng (HCEF-RG) was prepared from fine root concentrate (FR) and their antihypertensive effects were investigated in spontaneously hypertensive rats (SHR).
Methods: Male SHRs were divided into six groups: control (Wistar Kyoto, SHR); FR 500; FR 1,000; HCEF-RG 500; and HCEF-RG 1,000; samples (mg/kg body weight) were orally administered every day for 8 wk. Blood pressure was monitored at 1 wk, 2 wk, 3 wk, 4 wk, 6 wk, and 8 wk by tail cuff method. At 8 wk after samples administration, mice were killed for the measurement of renin activity (RA), angiotensin-I converting enzyme inhibition, angiotensin II, and nitric oxide (NO) levels in plasma.
Results: HCEF-RG with four-fold more Rg3 and 24-fold more Arg-Fru contents was successfully prepared from reacted mixtures of FR and persimmon vinegar (12 times against FR, v/v) at 80°C for 18 h. Both FR 1,000 and HCEF-RG 1,000 showed lowered systolic blood pressure than SHR control group and HCEF-RG 1,000 group exhibited a significant decrease in diastolic blood pressure. RA was significantly lowered in all treated groups, while angiotensin II did not affect by FR and HCEF-RG treatment. However, angiotensin-I converting enzyme inhibition and NO in FR 1,000 and HCEF-RG 1,000 were significantly increased compared with SHR control group.
Conclusion: HCEF-RG is more effective and useful for alleviating hypertension than FR, implying the health benefit of Rg3 and Arg-Fru. |
topic |
arginine–fructose blood pressure ginsenoside Rg3 hypotensive components-enriched Korean Red Ginseng |
url |
http://www.sciencedirect.com/science/article/pii/S1226845315000779 |
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