Antiplasmodial activity of traditional polyherbal remedy from Odisha, India: Their potential for prophylactic use
Objective: To evaluate the potential prophylactic activity of traditional polyherbal remedy against malaria. Methods: A traditional polyherbal remedy against malaria from Odisha, India was evaluated for its potential prophylactic activity using in vitro hepatic cell lines assay and the murine malari...
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Wolters Kluwer Medknow Publications
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doaj-139f59b946e449658ce1ab7c4fe5fed32020-11-24T20:52:16ZengWolters Kluwer Medknow PublicationsAsian Pacific Journal of Tropical Biomedicine2221-16912015-12-0151298298610.1016/j.apjtb.2015.09.002Antiplasmodial activity of traditional polyherbal remedy from Odisha, India: Their potential for prophylactic usePrakash Bangalore Nagendrappa0Jean-François Franetich1Frederick Gay2Audrey Lorthiois3Padma Venkatasubramanian4Dominique Mazier5Institute of Trans-Disciplinary Health Sciences and Technology, Foundation for Revitalisation of Local Health Traditions, 74/2, Jarakabande Kaval, Attur Post, Via Yelahanka, Bangalore 560 106, Karnataka, IndiaCimi-Paris (UPMC UMRS CR7, Inserm U1135, CNRS ERL 8255), Paris, FranceAP-HP, Pitié-Salpêtrière Hospital Group, Parasitology–Mycology Department, Paris, FranceCimi-Paris (UPMC UMRS CR7, Inserm U1135, CNRS ERL 8255), Paris, FranceInstitute of Trans-Disciplinary Health Sciences and Technology, Foundation for Revitalisation of Local Health Traditions, 74/2, Jarakabande Kaval, Attur Post, Via Yelahanka, Bangalore 560 106, Karnataka, IndiaCimi-Paris (UPMC UMRS CR7, Inserm U1135, CNRS ERL 8255), Paris, FranceObjective: To evaluate the potential prophylactic activity of traditional polyherbal remedy against malaria. Methods: A traditional polyherbal remedy against malaria from Odisha, India was evaluated for its potential prophylactic activity using in vitro hepatic cell lines assay and the murine malaria system Plasmodium yoelii yoelii/Anopheles stephensi. Results: The polyherbal extract inhibited the Plasmodium yoelii hepatic stages in vitro (IC50 0.74 mg/mL), a therapeutic index of 9.54. In mice treated with the aqueous extract (2000 mg/kg/day), peak parasitaemia values were 81% lower in the experimental 2.35% ± 0.14% as compared to controls 12.62% ± 0.52% (P < 0.001), suggesting significant prophylactic activity. Conclusions: The observations provide a proof of concept for a traditional malaria prophylactic remedy used by tribal populations in India.http://www.sciencedirect.com/science/article/pii/S2221169115002142Polyherbal remedyPlasmodiumMalaria prophylaxisAntiplasmodial activity |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Prakash Bangalore Nagendrappa Jean-François Franetich Frederick Gay Audrey Lorthiois Padma Venkatasubramanian Dominique Mazier |
spellingShingle |
Prakash Bangalore Nagendrappa Jean-François Franetich Frederick Gay Audrey Lorthiois Padma Venkatasubramanian Dominique Mazier Antiplasmodial activity of traditional polyherbal remedy from Odisha, India: Their potential for prophylactic use Asian Pacific Journal of Tropical Biomedicine Polyherbal remedy Plasmodium Malaria prophylaxis Antiplasmodial activity |
author_facet |
Prakash Bangalore Nagendrappa Jean-François Franetich Frederick Gay Audrey Lorthiois Padma Venkatasubramanian Dominique Mazier |
author_sort |
Prakash Bangalore Nagendrappa |
title |
Antiplasmodial activity of traditional polyherbal remedy from Odisha, India: Their potential for prophylactic use |
title_short |
Antiplasmodial activity of traditional polyherbal remedy from Odisha, India: Their potential for prophylactic use |
title_full |
Antiplasmodial activity of traditional polyherbal remedy from Odisha, India: Their potential for prophylactic use |
title_fullStr |
Antiplasmodial activity of traditional polyherbal remedy from Odisha, India: Their potential for prophylactic use |
title_full_unstemmed |
Antiplasmodial activity of traditional polyherbal remedy from Odisha, India: Their potential for prophylactic use |
title_sort |
antiplasmodial activity of traditional polyherbal remedy from odisha, india: their potential for prophylactic use |
publisher |
Wolters Kluwer Medknow Publications |
series |
Asian Pacific Journal of Tropical Biomedicine |
issn |
2221-1691 |
publishDate |
2015-12-01 |
description |
Objective: To evaluate the potential prophylactic activity of traditional polyherbal remedy against malaria.
Methods: A traditional polyherbal remedy against malaria from Odisha, India was evaluated for its potential prophylactic activity using in vitro hepatic cell lines assay and the murine malaria system Plasmodium yoelii yoelii/Anopheles stephensi.
Results: The polyherbal extract inhibited the Plasmodium yoelii hepatic stages in vitro (IC50 0.74 mg/mL), a therapeutic index of 9.54. In mice treated with the aqueous extract (2000 mg/kg/day), peak parasitaemia values were 81% lower in the experimental 2.35% ± 0.14% as compared to controls 12.62% ± 0.52% (P < 0.001), suggesting significant prophylactic activity.
Conclusions: The observations provide a proof of concept for a traditional malaria prophylactic remedy used by tribal populations in India. |
topic |
Polyherbal remedy Plasmodium Malaria prophylaxis Antiplasmodial activity |
url |
http://www.sciencedirect.com/science/article/pii/S2221169115002142 |
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