Predictive Value of Serial Measurements of sTREM-1 in the Treatment Response of Patients with Community-acquired Pneumonia
To evaluate the roles of plasma sTREM-1 (soluble triggering receptor expressed on myeloid cells-1) and C-reactive protein (CRP) in predicting treatment response in patients with community-acquired pneumonia (CAP). Methods: Patients with CAP were enrolled prospectively at a medical center in central...
Main Authors: | , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2007-01-01
|
Series: | Journal of the Formosan Medical Association |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S0929664609602394 |
id |
doaj-13a1895e2c4a463bb92e1d9842053cd6 |
---|---|
record_format |
Article |
spelling |
doaj-13a1895e2c4a463bb92e1d9842053cd62020-11-25T01:10:21ZengElsevierJournal of the Formosan Medical Association0929-66462007-01-01106318719510.1016/S0929-6646(09)60239-4Predictive Value of Serial Measurements of sTREM-1 in the Treatment Response of Patients with Community-acquired PneumoniaWen-Cheng Chao0Chia-Hui Wang1Ming-Cheng Chan2Kuan-Chih Chow3Jeng-Yuan Hsu4Chieh-Liang Wu5Division of Chest Medicine, Department of Internal Medicine, Taichung Veterans General Hospital, Taipei, TaiwanDepartment of Life Science and Graduate Institute of Biomedical Sciences, National Chung-Hsing University, Taipei, TaiwanDivision of Chest Medicine, Department of Internal Medicine, Taichung Veterans General Hospital, Taipei, TaiwanDepartment of Life Science and Graduate Institute of Biomedical Sciences, National Chung-Hsing University, Taipei, TaiwanDivision of Chest Medicine, Department of Internal Medicine, Taichung Veterans General Hospital, Taipei, TaiwanDivision of Critical Care and Respiratory Therapy, Department of Internal Medicine, Taichung Veterans General Hospital, Taipei, TaiwanTo evaluate the roles of plasma sTREM-1 (soluble triggering receptor expressed on myeloid cells-1) and C-reactive protein (CRP) in predicting treatment response in patients with community-acquired pneumonia (CAP). Methods: Patients with CAP were enrolled prospectively at a medical center in central Taiwan from September 1, 2004 to July 31, 2005. They were treated according to the guidelines proposed by the American Thoracic Society. Patients were noted as nonresponsive to initial treatment if they had one of the following: persistent fever for more than 3 days, progression on chest radiograph, switching to other antibiotics, or need of mechanical ventilation and/or chest tube drainage. Results: Fifty-eight patients (43 males/15 females; mean age, 67 ± 21 years) with CAP were enrolled. Twelve (12/58, 21%) were nonresponsive. In the response group, CRP was reduced up to 58% from day 1 to day 3 (from 18.8 to 7.8 mg/dL), whereas sTREM-1 was reduced by only 15% (from 32.8 to 28.1 pg/mL). In the nonresponse group, CRP still declined 20% (from 22.2 to 17.7 mg/dL), whereas sTREM-1 was persistently high (from 61.7 to 63.7 pg/mL). Using multivariate logistic regression analysis, both CRP (p = 0.006) and sTREM-1 (p = 0.046) on day 3 predicted treatment response significantly, but CRP on day 3 had stronger statistic power. Conclusion: Both CRP and sTREM-1 on day 3 could be useful in predicting nonresponsive CAP patients. Differential trends between sTREM-1 and CRP in nonresponsive CAP suggest that sTREM-1 could be an adjuvant biomarker to CRP in predicting CAP patients without response to empiric treatment. [J Formos Med Assoc 2007;106(3):187-195]http://www.sciencedirect.com/science/article/pii/S0929664609602394C-reactive proteincommunity-acquired pneumoniaTaiwantreatment failureTREM-1 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Wen-Cheng Chao Chia-Hui Wang Ming-Cheng Chan Kuan-Chih Chow Jeng-Yuan Hsu Chieh-Liang Wu |
spellingShingle |
Wen-Cheng Chao Chia-Hui Wang Ming-Cheng Chan Kuan-Chih Chow Jeng-Yuan Hsu Chieh-Liang Wu Predictive Value of Serial Measurements of sTREM-1 in the Treatment Response of Patients with Community-acquired Pneumonia Journal of the Formosan Medical Association C-reactive protein community-acquired pneumonia Taiwan treatment failure TREM-1 |
author_facet |
Wen-Cheng Chao Chia-Hui Wang Ming-Cheng Chan Kuan-Chih Chow Jeng-Yuan Hsu Chieh-Liang Wu |
author_sort |
Wen-Cheng Chao |
title |
Predictive Value of Serial Measurements of sTREM-1 in the Treatment Response of Patients with Community-acquired Pneumonia |
title_short |
Predictive Value of Serial Measurements of sTREM-1 in the Treatment Response of Patients with Community-acquired Pneumonia |
title_full |
Predictive Value of Serial Measurements of sTREM-1 in the Treatment Response of Patients with Community-acquired Pneumonia |
title_fullStr |
Predictive Value of Serial Measurements of sTREM-1 in the Treatment Response of Patients with Community-acquired Pneumonia |
title_full_unstemmed |
Predictive Value of Serial Measurements of sTREM-1 in the Treatment Response of Patients with Community-acquired Pneumonia |
title_sort |
predictive value of serial measurements of strem-1 in the treatment response of patients with community-acquired pneumonia |
publisher |
Elsevier |
series |
Journal of the Formosan Medical Association |
issn |
0929-6646 |
publishDate |
2007-01-01 |
description |
To evaluate the roles of plasma sTREM-1 (soluble triggering receptor expressed on myeloid cells-1) and C-reactive protein (CRP) in predicting treatment response in patients with community-acquired pneumonia (CAP).
Methods: Patients with CAP were enrolled prospectively at a medical center in central Taiwan from September 1, 2004 to July 31, 2005. They were treated according to the guidelines proposed by the American Thoracic Society. Patients were noted as nonresponsive to initial treatment if they had one of the following: persistent fever for more than 3 days, progression on chest radiograph, switching to other antibiotics, or need of mechanical ventilation and/or chest tube drainage.
Results: Fifty-eight patients (43 males/15 females; mean age, 67 ± 21 years) with CAP were enrolled. Twelve (12/58, 21%) were nonresponsive. In the response group, CRP was reduced up to 58% from day 1 to day 3 (from 18.8 to 7.8 mg/dL), whereas sTREM-1 was reduced by only 15% (from 32.8 to 28.1 pg/mL). In the nonresponse group, CRP still declined 20% (from 22.2 to 17.7 mg/dL), whereas sTREM-1 was persistently high (from 61.7 to 63.7 pg/mL). Using multivariate logistic regression analysis, both CRP (p = 0.006) and sTREM-1 (p = 0.046) on day 3 predicted treatment response significantly, but CRP on day 3 had stronger statistic power.
Conclusion: Both CRP and sTREM-1 on day 3 could be useful in predicting nonresponsive CAP patients. Differential trends between sTREM-1 and CRP in nonresponsive CAP suggest that sTREM-1 could be an adjuvant biomarker to CRP in predicting CAP patients without response to empiric treatment. [J Formos Med Assoc 2007;106(3):187-195] |
topic |
C-reactive protein community-acquired pneumonia Taiwan treatment failure TREM-1 |
url |
http://www.sciencedirect.com/science/article/pii/S0929664609602394 |
work_keys_str_mv |
AT wenchengchao predictivevalueofserialmeasurementsofstrem1inthetreatmentresponseofpatientswithcommunityacquiredpneumonia AT chiahuiwang predictivevalueofserialmeasurementsofstrem1inthetreatmentresponseofpatientswithcommunityacquiredpneumonia AT mingchengchan predictivevalueofserialmeasurementsofstrem1inthetreatmentresponseofpatientswithcommunityacquiredpneumonia AT kuanchihchow predictivevalueofserialmeasurementsofstrem1inthetreatmentresponseofpatientswithcommunityacquiredpneumonia AT jengyuanhsu predictivevalueofserialmeasurementsofstrem1inthetreatmentresponseofpatientswithcommunityacquiredpneumonia AT chiehliangwu predictivevalueofserialmeasurementsofstrem1inthetreatmentresponseofpatientswithcommunityacquiredpneumonia |
_version_ |
1725175297175715840 |