Effect of a single bout of morning or afternoon exercise on glucose fluctuation in young healthy men

• Main Authors: Yoshiaki Tanaka, Hitomi Ogata, Insung Park, Akira Ando, Asuka Ishihara, Momoko Kayaba, Katsuhiko Yajima, Chihiro Suzuki, Akihiro Araki, Haruka Osumi, Simeng Zhang, Jaehoon Seol, Keigo Takahashi, Yoshiharu Nabekura, Makoto Satoh, Kumpei Tokuyama
• Format: Article
• Language: English
• Published: Wiley 2021-04-01
• Series: Physiological Reports
• Subjects: continuous glucose monitoring; exercise timing; glucose fluctuation
• Online Access: https://doi.org/10.14814/phy2.14784

Abstract The timing of exercise plays an important role in the effect of the exercise on physiological functions, such as substrate oxidation and circadian rhythm. Exercise exerts different effects on the glycemic response to exercise and meal intake depending on when the exercise performed. Here, we comprehensively investigated the effects of the timing (morning or afternoon) of exercise on glucose fluctuation on the basis of several indices: glycemic variability over 24 h (24‐h SD), J‐index, mean amplitude of glucose excursions (MAGE), continuous overall net glycemic action (CONGA), and detrended fluctuation analysis (DFA). Eleven young men participated in 3 trials in a repeated measures design in which they performed a single bout of exercise at 60% of their maximal oxygen uptake for 1 h beginning either at 7:00 (morning exercise), 16:00 (afternoon exercise), or no exercise (control). Glucose levels were measured using a continuous glucose monitoring system (CGMs). Glucose fluctuation was slightly less stable when exercise was performed in the afternoon than in the morning, indicated by higher CONGA at 2 h and α2 in DFA in the afternoon exercise trial than in the control trial. Additionally, decreased stability in glucose fluctuation in the afternoon exercise trial was supported by the descending values of the other glucose fluctuation indices in order from the afternoon exercise, morning exercise, and control trials. Meal tolerance following exercise was decreased after both exercise trials. Glucose levels during exercise were decreased only in the afternoon exercise trial, resulting in less stable glucose fluctuations over 24 h.