Transplacental inhibitory effect of carrot juice on the clastogenicity of cyclophosphamide in mice
Genetic damage during the prenatal period can provoke important neoplastic alterations and other diseases in postnatal life. Beta-carotene (ßC) is considered to be one of the most important anticarcinogens in the diet and can protect mammalian cells against genotoxic events. As carrots are important...
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Sociedade Brasileira de Genética
1999-01-01
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Series: | Genetics and Molecular Biology |
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doaj-13a69847691749969064f2ff01cc8a4f2020-11-25T02:47:01ZengSociedade Brasileira de GenéticaGenetics and Molecular Biology1415-47571678-46851999-01-012216568Transplacental inhibitory effect of carrot juice on the clastogenicity of cyclophosphamide in miceGimmler-Luz Maria ClaraCardoso Valesca VeigaSardiglia Cassius UgarteWidholzer Débora da SilvaGenetic damage during the prenatal period can provoke important neoplastic alterations and other diseases in postnatal life. Beta-carotene (ßC) is considered to be one of the most important anticarcinogens in the diet and can protect mammalian cells against genotoxic events. As carrots are important dietary source of ßC, we decided to test the effect of fresh carrot juice (CaJ) on cyclophosphamide (CP)-induced genotoxicity in maternal and fetal erythropoietic tissues. The treatment with CaJ started on the 7th day of the pregnancy of BALB/c female mice. We observed, on the 16th gestational day, that this treatment did not modify the spontaneous frequency of micronucleated polychromatic erythrocytes (mPCE) in the bone marrow of the females nor in the livers of their fetuses. The mPCE frequency observed 24 h after an intraperitoneal injection of CP (40 mg/kg) on the 15th day was significantly lower in CaJ-pretreated pregnant female bone marrow and in the liver of their fetuses than those observed in the group treated with CP only. These results demonstrate the presence of natural anticlastogens in carrots.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47571999000100013 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Gimmler-Luz Maria Clara Cardoso Valesca Veiga Sardiglia Cassius Ugarte Widholzer Débora da Silva |
spellingShingle |
Gimmler-Luz Maria Clara Cardoso Valesca Veiga Sardiglia Cassius Ugarte Widholzer Débora da Silva Transplacental inhibitory effect of carrot juice on the clastogenicity of cyclophosphamide in mice Genetics and Molecular Biology |
author_facet |
Gimmler-Luz Maria Clara Cardoso Valesca Veiga Sardiglia Cassius Ugarte Widholzer Débora da Silva |
author_sort |
Gimmler-Luz Maria Clara |
title |
Transplacental inhibitory effect of carrot juice on the clastogenicity of cyclophosphamide in mice |
title_short |
Transplacental inhibitory effect of carrot juice on the clastogenicity of cyclophosphamide in mice |
title_full |
Transplacental inhibitory effect of carrot juice on the clastogenicity of cyclophosphamide in mice |
title_fullStr |
Transplacental inhibitory effect of carrot juice on the clastogenicity of cyclophosphamide in mice |
title_full_unstemmed |
Transplacental inhibitory effect of carrot juice on the clastogenicity of cyclophosphamide in mice |
title_sort |
transplacental inhibitory effect of carrot juice on the clastogenicity of cyclophosphamide in mice |
publisher |
Sociedade Brasileira de Genética |
series |
Genetics and Molecular Biology |
issn |
1415-4757 1678-4685 |
publishDate |
1999-01-01 |
description |
Genetic damage during the prenatal period can provoke important neoplastic alterations and other diseases in postnatal life. Beta-carotene (ßC) is considered to be one of the most important anticarcinogens in the diet and can protect mammalian cells against genotoxic events. As carrots are important dietary source of ßC, we decided to test the effect of fresh carrot juice (CaJ) on cyclophosphamide (CP)-induced genotoxicity in maternal and fetal erythropoietic tissues. The treatment with CaJ started on the 7th day of the pregnancy of BALB/c female mice. We observed, on the 16th gestational day, that this treatment did not modify the spontaneous frequency of micronucleated polychromatic erythrocytes (mPCE) in the bone marrow of the females nor in the livers of their fetuses. The mPCE frequency observed 24 h after an intraperitoneal injection of CP (40 mg/kg) on the 15th day was significantly lower in CaJ-pretreated pregnant female bone marrow and in the liver of their fetuses than those observed in the group treated with CP only. These results demonstrate the presence of natural anticlastogens in carrots. |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47571999000100013 |
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