Mortality and morbidity in community-acquired sepsis in European pediatric intensive care units: a prospective cohort study from the European Childhood Life-threatening Infectious Disease Study (EUCLIDS)
Abstract Background Sepsis is one of the main reasons for non-elective admission to pediatric intensive care units (PICUs), but little is known about determinants influencing outcome. We characterized children admitted with community-acquired sepsis to European PICUs and studied risk factors for mor...
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2018-05-01
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Online Access: | http://link.springer.com/article/10.1186/s13054-018-2052-7 |
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Article |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Navin P. Boeddha Luregn J. Schlapbach Gertjan J. Driessen Jethro A. Herberg Irene Rivero-Calle Miriam Cebey-López Daniela S. Klobassa Ria Philipsen Ronald de Groot David P. Inwald Simon Nadel Stéphane Paulus Eleanor Pinnock Fatou Secka Suzanne T. Anderson Rachel S. Agbeko Christoph Berger Colin G. Fink Enitan D. Carrol Werner Zenz Michael Levin Michiel van der Flier Federico Martinón-Torres Jan A. Hazelzet Marieke Emonts on behalf of the EUCLIDS consortium |
spellingShingle |
Navin P. Boeddha Luregn J. Schlapbach Gertjan J. Driessen Jethro A. Herberg Irene Rivero-Calle Miriam Cebey-López Daniela S. Klobassa Ria Philipsen Ronald de Groot David P. Inwald Simon Nadel Stéphane Paulus Eleanor Pinnock Fatou Secka Suzanne T. Anderson Rachel S. Agbeko Christoph Berger Colin G. Fink Enitan D. Carrol Werner Zenz Michael Levin Michiel van der Flier Federico Martinón-Torres Jan A. Hazelzet Marieke Emonts on behalf of the EUCLIDS consortium Mortality and morbidity in community-acquired sepsis in European pediatric intensive care units: a prospective cohort study from the European Childhood Life-threatening Infectious Disease Study (EUCLIDS) Critical Care Bacteremia Meningococcal infections Pneumococcal infections Mortality Morbidity |
author_facet |
Navin P. Boeddha Luregn J. Schlapbach Gertjan J. Driessen Jethro A. Herberg Irene Rivero-Calle Miriam Cebey-López Daniela S. Klobassa Ria Philipsen Ronald de Groot David P. Inwald Simon Nadel Stéphane Paulus Eleanor Pinnock Fatou Secka Suzanne T. Anderson Rachel S. Agbeko Christoph Berger Colin G. Fink Enitan D. Carrol Werner Zenz Michael Levin Michiel van der Flier Federico Martinón-Torres Jan A. Hazelzet Marieke Emonts on behalf of the EUCLIDS consortium |
author_sort |
Navin P. Boeddha |
title |
Mortality and morbidity in community-acquired sepsis in European pediatric intensive care units: a prospective cohort study from the European Childhood Life-threatening Infectious Disease Study (EUCLIDS) |
title_short |
Mortality and morbidity in community-acquired sepsis in European pediatric intensive care units: a prospective cohort study from the European Childhood Life-threatening Infectious Disease Study (EUCLIDS) |
title_full |
Mortality and morbidity in community-acquired sepsis in European pediatric intensive care units: a prospective cohort study from the European Childhood Life-threatening Infectious Disease Study (EUCLIDS) |
title_fullStr |
Mortality and morbidity in community-acquired sepsis in European pediatric intensive care units: a prospective cohort study from the European Childhood Life-threatening Infectious Disease Study (EUCLIDS) |
title_full_unstemmed |
Mortality and morbidity in community-acquired sepsis in European pediatric intensive care units: a prospective cohort study from the European Childhood Life-threatening Infectious Disease Study (EUCLIDS) |
title_sort |
mortality and morbidity in community-acquired sepsis in european pediatric intensive care units: a prospective cohort study from the european childhood life-threatening infectious disease study (euclids) |
publisher |
BMC |
series |
Critical Care |
issn |
1364-8535 |
publishDate |
2018-05-01 |
description |
Abstract Background Sepsis is one of the main reasons for non-elective admission to pediatric intensive care units (PICUs), but little is known about determinants influencing outcome. We characterized children admitted with community-acquired sepsis to European PICUs and studied risk factors for mortality and disability. Methods Data were collected within the collaborative Seventh Framework Programme (FP7)-funded EUCLIDS study, which is a prospective multicenter cohort study aiming to evaluate genetic determinants of susceptibility and/or severity in sepsis. This report includes 795 children admitted with community-acquired sepsis to 52 PICUs from seven European countries between July 2012 and January 2016. The primary outcome measure was in-hospital death. Secondary outcome measures were PICU-free days censured at day 28, hospital length of stay, and disability. Independent predictors were identified by multivariate regression analysis. Results Patients most commonly presented clinically with sepsis without a source (n = 278, 35%), meningitis/encephalitis (n = 182, 23%), or pneumonia (n = 149, 19%). Of 428 (54%) patients with confirmed bacterial infection, Neisseria meningitidis (n = 131, 31%) and Streptococcus pneumoniae (n = 78, 18%) were the main pathogens. Mortality was 6% (51/795), increasing to 10% in the presence of septic shock (45/466). Of the survivors, 31% were discharged with disability, including 24% of previously healthy children who survived with disability. Mortality and disability were independently associated with S. pneumoniae infections (mortality OR 4.1, 95% CI 1.1–16.0, P = 0.04; disability OR 5.4, 95% CI 1.8–15.8, P < 0.01) and illness severity as measured by Pediatric Index of Mortality (PIM2) score (mortality OR 2.8, 95% CI 1.3–6.1, P < 0.01; disability OR 3.4, 95% CI 1.8–6.4, P < 0.001). Conclusions Despite widespread immunization campaigns, invasive bacterial disease remains responsible for substantial morbidity and mortality in critically ill children in high-income countries. Almost one third of sepsis survivors admitted to the PICU were discharged with some disability. More research is required to delineate the long-term outcome of pediatric sepsis and to identify interventional targets. Our findings emphasize the importance of improved early sepsis-recognition programs to address the high burden of disease. |
topic |
Bacteremia Meningococcal infections Pneumococcal infections Mortality Morbidity |
url |
http://link.springer.com/article/10.1186/s13054-018-2052-7 |
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doaj-13b9ec1324764aaebd05ec2c3ffc61352020-11-25T02:34:01ZengBMCCritical Care1364-85352018-05-0122111310.1186/s13054-018-2052-7Mortality and morbidity in community-acquired sepsis in European pediatric intensive care units: a prospective cohort study from the European Childhood Life-threatening Infectious Disease Study (EUCLIDS)Navin P. Boeddha0Luregn J. Schlapbach1Gertjan J. Driessen2Jethro A. Herberg3Irene Rivero-Calle4Miriam Cebey-López5Daniela S. Klobassa6Ria Philipsen7Ronald de Groot8David P. Inwald9Simon Nadel10Stéphane Paulus11Eleanor Pinnock12Fatou Secka13Suzanne T. Anderson14Rachel S. Agbeko15Christoph Berger16Colin G. Fink17Enitan D. Carrol18Werner Zenz19Michael Levin20Michiel van der Flier21Federico Martinón-Torres22Jan A. Hazelzet23Marieke Emonts24on behalf of the EUCLIDS consortiumIntensive Care and Department of Pediatric Surgery, Erasmus MC-Sophia Children’s Hospital, University Medical Center RotterdamFaculty of Medicine, The University of QueenslandDepartment of Pediatrics, Division of Pediatric Infectious Diseases & Immunology, Erasmus MC-Sophia Children’s Hospital, University Medical Center RotterdamSection of Pediatrics, Imperial College LondonTranslational Pediatrics and Infectious Diseases Section- Pediatrics Department, Hospital Clínico Universitario de Santiago de CompostelaGenetics- Vaccines- Infectious Diseases and Pediatrics research group GENVIP, Health Research Institute of Santiago IDIS/SERGASDepartment of General Paediatrics, Medical University of GrazRadboudumc Technology Center Clinical Studies, RadboudumcSection of Pediatric Infectious Diseases, Laboratory of Medical Immunology, Radboud Institute for Molecular Life SciencesDepartment of Paediatrics, Faculty of Medicine, Imperial College London, South Kensington CampusDepartment of Paediatrics, Faculty of Medicine, Imperial College London, South Kensington CampusDivision of Paediatric Infectious Diseases, Alder Hey Children’s NHS Foundation TrustMicropathology Ltd, University of Warwick Science ParkMedical research Council UnitMedical research Council UnitDepartment of Paediatric Intensive Care, Great North Children’s Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, Victoria WingDivision of Infectious Diseases and Hospital Epidemiology, and Children’s Research Center, University Children’s Hospital ZurichMicropathology Ltd, University of Warwick Science ParkInstitute of Infection & Global Health, University of LiverpoolDepartment of General Paediatrics, Medical University of GrazSection of Pediatrics, Imperial College LondonRadboudumc Technology Center Clinical Studies, RadboudumcTranslational Pediatrics and Infectious Diseases Section- Pediatrics Department, Hospital Clínico Universitario de Santiago de CompostelaDepartment of Public Health, Erasmus MC, University Medical Center RotterdamInstitute of Cellular Medicine, Newcastle UniversityAbstract Background Sepsis is one of the main reasons for non-elective admission to pediatric intensive care units (PICUs), but little is known about determinants influencing outcome. We characterized children admitted with community-acquired sepsis to European PICUs and studied risk factors for mortality and disability. Methods Data were collected within the collaborative Seventh Framework Programme (FP7)-funded EUCLIDS study, which is a prospective multicenter cohort study aiming to evaluate genetic determinants of susceptibility and/or severity in sepsis. This report includes 795 children admitted with community-acquired sepsis to 52 PICUs from seven European countries between July 2012 and January 2016. The primary outcome measure was in-hospital death. Secondary outcome measures were PICU-free days censured at day 28, hospital length of stay, and disability. Independent predictors were identified by multivariate regression analysis. Results Patients most commonly presented clinically with sepsis without a source (n = 278, 35%), meningitis/encephalitis (n = 182, 23%), or pneumonia (n = 149, 19%). Of 428 (54%) patients with confirmed bacterial infection, Neisseria meningitidis (n = 131, 31%) and Streptococcus pneumoniae (n = 78, 18%) were the main pathogens. Mortality was 6% (51/795), increasing to 10% in the presence of septic shock (45/466). Of the survivors, 31% were discharged with disability, including 24% of previously healthy children who survived with disability. Mortality and disability were independently associated with S. pneumoniae infections (mortality OR 4.1, 95% CI 1.1–16.0, P = 0.04; disability OR 5.4, 95% CI 1.8–15.8, P < 0.01) and illness severity as measured by Pediatric Index of Mortality (PIM2) score (mortality OR 2.8, 95% CI 1.3–6.1, P < 0.01; disability OR 3.4, 95% CI 1.8–6.4, P < 0.001). Conclusions Despite widespread immunization campaigns, invasive bacterial disease remains responsible for substantial morbidity and mortality in critically ill children in high-income countries. Almost one third of sepsis survivors admitted to the PICU were discharged with some disability. More research is required to delineate the long-term outcome of pediatric sepsis and to identify interventional targets. Our findings emphasize the importance of improved early sepsis-recognition programs to address the high burden of disease.http://link.springer.com/article/10.1186/s13054-018-2052-7BacteremiaMeningococcal infectionsPneumococcal infectionsMortalityMorbidity |