Peptidoglycan reshaping by a noncanonical peptidase for helical cell shape in Campylobacter jejuni
Peptidoglycans (PG) define bacterial cell shapes. Here, the authors provide mechanistic insights into the peptidoglycan peptidase 3 (Pgp3) from the spiral shaped human pathogen Campylobacter jejuni by determining its crystal structure alone and in complex with synthetic cell-wall PG derivatives, and...
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2020-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-13934-4 |
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doaj-13c1a77948d7413ba83fdcf089e8a2782021-05-11T09:18:09ZengNature Publishing GroupNature Communications2041-17232020-01-0111111110.1038/s41467-019-13934-4Peptidoglycan reshaping by a noncanonical peptidase for helical cell shape in Campylobacter jejuniKyungjin Min0Doo Ri An1Hye-Jin Yoon2Neha Rana3Ji Su Park4Jinshil Kim5Mijoon Lee6Dusan Hesek7Sangryeol Ryu8B. Moon Kim9Shahriar Mobashery10Se Won Suh11Hyung Ho Lee12Department of Chemistry, College of Natural Sciences, Seoul National UniversityDepartment of Biophysics and Chemical Biology, College of Natural Sciences, Seoul National UniversityDepartment of Chemistry, College of Natural Sciences, Seoul National UniversityDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre DameDepartment of Chemistry, College of Natural Sciences, Seoul National UniversityDepartment of Food and Animal Biotechnology, Department of Agricultural Biotechnology, and Research Institute for Agriculture and Life Sciences, Seoul National UniversityDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre DameDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre DameDepartment of Food and Animal Biotechnology, Department of Agricultural Biotechnology, and Research Institute for Agriculture and Life Sciences, Seoul National UniversityDepartment of Chemistry, College of Natural Sciences, Seoul National UniversityDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre DameDepartment of Chemistry, College of Natural Sciences, Seoul National UniversityDepartment of Chemistry, College of Natural Sciences, Seoul National UniversityPeptidoglycans (PG) define bacterial cell shapes. Here, the authors provide mechanistic insights into the peptidoglycan peptidase 3 (Pgp3) from the spiral shaped human pathogen Campylobacter jejuni by determining its crystal structure alone and in complex with synthetic cell-wall PG derivatives, and they further show that the enzyme has both d,d-endopeptidase and d,d-carboxypeptidase activitieshttps://doi.org/10.1038/s41467-019-13934-4 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Kyungjin Min Doo Ri An Hye-Jin Yoon Neha Rana Ji Su Park Jinshil Kim Mijoon Lee Dusan Hesek Sangryeol Ryu B. Moon Kim Shahriar Mobashery Se Won Suh Hyung Ho Lee |
| spellingShingle |
Kyungjin Min Doo Ri An Hye-Jin Yoon Neha Rana Ji Su Park Jinshil Kim Mijoon Lee Dusan Hesek Sangryeol Ryu B. Moon Kim Shahriar Mobashery Se Won Suh Hyung Ho Lee Peptidoglycan reshaping by a noncanonical peptidase for helical cell shape in Campylobacter jejuni Nature Communications |
| author_facet |
Kyungjin Min Doo Ri An Hye-Jin Yoon Neha Rana Ji Su Park Jinshil Kim Mijoon Lee Dusan Hesek Sangryeol Ryu B. Moon Kim Shahriar Mobashery Se Won Suh Hyung Ho Lee |
| author_sort |
Kyungjin Min |
| title |
Peptidoglycan reshaping by a noncanonical peptidase for helical cell shape in Campylobacter jejuni |
| title_short |
Peptidoglycan reshaping by a noncanonical peptidase for helical cell shape in Campylobacter jejuni |
| title_full |
Peptidoglycan reshaping by a noncanonical peptidase for helical cell shape in Campylobacter jejuni |
| title_fullStr |
Peptidoglycan reshaping by a noncanonical peptidase for helical cell shape in Campylobacter jejuni |
| title_full_unstemmed |
Peptidoglycan reshaping by a noncanonical peptidase for helical cell shape in Campylobacter jejuni |
| title_sort |
peptidoglycan reshaping by a noncanonical peptidase for helical cell shape in campylobacter jejuni |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2020-01-01 |
| description |
Peptidoglycans (PG) define bacterial cell shapes. Here, the authors provide mechanistic insights into the peptidoglycan peptidase 3 (Pgp3) from the spiral shaped human pathogen Campylobacter jejuni by determining its crystal structure alone and in complex with synthetic cell-wall PG derivatives, and they further show that the enzyme has both d,d-endopeptidase and d,d-carboxypeptidase activities |
| url |
https://doi.org/10.1038/s41467-019-13934-4 |
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