Potential Role of Mic60/Mitofilin in Parkinson’s Disease
There are currently no treatments that hinder or halt the inexorable progression of Parkinson’s disease (PD). While the etiology of PD remains elusive, evidence suggests that early dysfunction of mitochondrial respiration and homeostasis play a major role in PD pathogenesis. The mitochondrial struct...
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doaj-13c59150f21b4e96955ee292fcd4e4d32020-11-25T00:41:59ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2019-01-011210.3389/fnins.2018.00898429303Potential Role of Mic60/Mitofilin in Parkinson’s DiseaseVictor S. Van Laar0Victor S. Van Laar1P. Anthony Otero2P. Anthony Otero3P. Anthony Otero4Teresa G. Hastings5Teresa G. Hastings6Teresa G. Hastings7Sarah B. Berman8Sarah B. Berman9Sarah B. Berman10Department of Neurology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, United StatesPittsburgh Institute for Neurodegenerative Diseases, University of Pittsburgh, Pittsburgh, PA, United StatesPittsburgh Institute for Neurodegenerative Diseases, University of Pittsburgh, Pittsburgh, PA, United StatesDivision of Neuropathology, Department of Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, United StatesCellular and Molecular Pathology (CMP) Program, Department of Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, United StatesDepartment of Neurology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, United StatesPittsburgh Institute for Neurodegenerative Diseases, University of Pittsburgh, Pittsburgh, PA, United StatesDepartment of Neuroscience, University of Pittsburgh, Pittsburgh, PA, United StatesDepartment of Neurology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, United StatesPittsburgh Institute for Neurodegenerative Diseases, University of Pittsburgh, Pittsburgh, PA, United StatesClinical and Translational Science Institute, University of Pittsburgh, Pittsburgh, PA, United StatesThere are currently no treatments that hinder or halt the inexorable progression of Parkinson’s disease (PD). While the etiology of PD remains elusive, evidence suggests that early dysfunction of mitochondrial respiration and homeostasis play a major role in PD pathogenesis. The mitochondrial structural protein Mic60, also known as mitofilin, is critical for maintaining mitochondrial architecture and function. Loss of Mic60 is associated with detrimental effects on mitochondrial homeostasis. Growing evidence now implicates Mic60 in the pathogenesis of PD. In this review, we discuss the data supporting a role of Mic60 and mitochondrial dysfunction in PD. We will also consider the potential of Mic60 as a therapeutic target for treating neurological disorders.https://www.frontiersin.org/article/10.3389/fnins.2018.00898/fullMic60/mitofilinmitochondriaParkinson’s diseaseneurodegenerationmitochondrial dynamics |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Victor S. Van Laar Victor S. Van Laar P. Anthony Otero P. Anthony Otero P. Anthony Otero Teresa G. Hastings Teresa G. Hastings Teresa G. Hastings Sarah B. Berman Sarah B. Berman Sarah B. Berman |
spellingShingle |
Victor S. Van Laar Victor S. Van Laar P. Anthony Otero P. Anthony Otero P. Anthony Otero Teresa G. Hastings Teresa G. Hastings Teresa G. Hastings Sarah B. Berman Sarah B. Berman Sarah B. Berman Potential Role of Mic60/Mitofilin in Parkinson’s Disease Frontiers in Neuroscience Mic60/mitofilin mitochondria Parkinson’s disease neurodegeneration mitochondrial dynamics |
author_facet |
Victor S. Van Laar Victor S. Van Laar P. Anthony Otero P. Anthony Otero P. Anthony Otero Teresa G. Hastings Teresa G. Hastings Teresa G. Hastings Sarah B. Berman Sarah B. Berman Sarah B. Berman |
author_sort |
Victor S. Van Laar |
title |
Potential Role of Mic60/Mitofilin in Parkinson’s Disease |
title_short |
Potential Role of Mic60/Mitofilin in Parkinson’s Disease |
title_full |
Potential Role of Mic60/Mitofilin in Parkinson’s Disease |
title_fullStr |
Potential Role of Mic60/Mitofilin in Parkinson’s Disease |
title_full_unstemmed |
Potential Role of Mic60/Mitofilin in Parkinson’s Disease |
title_sort |
potential role of mic60/mitofilin in parkinson’s disease |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Neuroscience |
issn |
1662-453X |
publishDate |
2019-01-01 |
description |
There are currently no treatments that hinder or halt the inexorable progression of Parkinson’s disease (PD). While the etiology of PD remains elusive, evidence suggests that early dysfunction of mitochondrial respiration and homeostasis play a major role in PD pathogenesis. The mitochondrial structural protein Mic60, also known as mitofilin, is critical for maintaining mitochondrial architecture and function. Loss of Mic60 is associated with detrimental effects on mitochondrial homeostasis. Growing evidence now implicates Mic60 in the pathogenesis of PD. In this review, we discuss the data supporting a role of Mic60 and mitochondrial dysfunction in PD. We will also consider the potential of Mic60 as a therapeutic target for treating neurological disorders. |
topic |
Mic60/mitofilin mitochondria Parkinson’s disease neurodegeneration mitochondrial dynamics |
url |
https://www.frontiersin.org/article/10.3389/fnins.2018.00898/full |
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