Is an Early Age at Illness Onset in Schizophrenia Associated With Increased Genetic Susceptibility? Analysis of Data From the Nationwide Danish Twin Register
Background: Early age at illness onset has been viewed as an important liability marker for schizophrenia, which may be associated with an increased genetic vulnerability. A twin approach can be valuable, because it allows for the investigation of specific illness markers in individuals with a share...
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doaj-13db1d8612324fb488c1e7e97378dd152020-11-25T03:25:11ZengElsevierEBioMedicine2352-39642017-04-0118C32032610.1016/j.ebiom.2017.04.002Is an Early Age at Illness Onset in Schizophrenia Associated With Increased Genetic Susceptibility? Analysis of Data From the Nationwide Danish Twin RegisterRikke Hilker0Dorte Helenius1Birgitte Fagerlund2Axel Skytthe3Kaare Christensen4Thomas M. Werge5Merete Nordentoft6Birte Glenthøj7Lundbeck Foundation Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research (CINS), DenmarkMental Health Center Sct. Hans, Mental Health Services, Capital Region Denmark, DK-4000, Roskilde, DenmarkLundbeck Foundation Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research (CINS), DenmarkThe Danish Twin Register, University of Southern Denmark, DK-5000, Odense C, DenmarkThe Danish Twin Register, University of Southern Denmark, DK-5000, Odense C, DenmarkLundbeck Foundation Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research (CINS), DenmarkLundbeck Foundation Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research (CINS), DenmarkLundbeck Foundation Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research (CINS), DenmarkBackground: Early age at illness onset has been viewed as an important liability marker for schizophrenia, which may be associated with an increased genetic vulnerability. A twin approach can be valuable, because it allows for the investigation of specific illness markers in individuals with a shared genetic background. Methods: We linked nationwide registers to identify a cohort of twin pairs born in Denmark from 1951 to 2000 (N = 31,524 pairs), where one or both twins had a diagnosis in the schizophrenia spectrum. We defined two groups consisting of; N = 788 twin pairs (affected with schizophrenia spectrum) and a subsample of N = 448 (affected with schizophrenia). Survival analysis was applied to investigate the effect of age at illness onset. Findings: We found that early age at illness onset compared to later onset in the first diagnosed twin can be considered a major risk factor for developing schizophrenia in the second twin. Additionally, we found that the stronger genetic component in MZ twins compared to DZ twins is manifested in the proximity of assigned diagnosis within pairs. Discussion: Early onset schizophrenia could be linked to a more severe genetic predisposition, indicating that age might be perceived as a clinical marker for genetic vulnerability for the illness.http://www.sciencedirect.com/science/article/pii/S2352396417301445Twin studyAge at onsetSchizophreniaNationwide register-based data |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Rikke Hilker Dorte Helenius Birgitte Fagerlund Axel Skytthe Kaare Christensen Thomas M. Werge Merete Nordentoft Birte Glenthøj |
spellingShingle |
Rikke Hilker Dorte Helenius Birgitte Fagerlund Axel Skytthe Kaare Christensen Thomas M. Werge Merete Nordentoft Birte Glenthøj Is an Early Age at Illness Onset in Schizophrenia Associated With Increased Genetic Susceptibility? Analysis of Data From the Nationwide Danish Twin Register EBioMedicine Twin study Age at onset Schizophrenia Nationwide register-based data |
author_facet |
Rikke Hilker Dorte Helenius Birgitte Fagerlund Axel Skytthe Kaare Christensen Thomas M. Werge Merete Nordentoft Birte Glenthøj |
author_sort |
Rikke Hilker |
title |
Is an Early Age at Illness Onset in Schizophrenia Associated With Increased Genetic Susceptibility? Analysis of Data From the Nationwide Danish Twin Register |
title_short |
Is an Early Age at Illness Onset in Schizophrenia Associated With Increased Genetic Susceptibility? Analysis of Data From the Nationwide Danish Twin Register |
title_full |
Is an Early Age at Illness Onset in Schizophrenia Associated With Increased Genetic Susceptibility? Analysis of Data From the Nationwide Danish Twin Register |
title_fullStr |
Is an Early Age at Illness Onset in Schizophrenia Associated With Increased Genetic Susceptibility? Analysis of Data From the Nationwide Danish Twin Register |
title_full_unstemmed |
Is an Early Age at Illness Onset in Schizophrenia Associated With Increased Genetic Susceptibility? Analysis of Data From the Nationwide Danish Twin Register |
title_sort |
is an early age at illness onset in schizophrenia associated with increased genetic susceptibility? analysis of data from the nationwide danish twin register |
publisher |
Elsevier |
series |
EBioMedicine |
issn |
2352-3964 |
publishDate |
2017-04-01 |
description |
Background: Early age at illness onset has been viewed as an important liability marker for schizophrenia, which may be associated with an increased genetic vulnerability. A twin approach can be valuable, because it allows for the investigation of specific illness markers in individuals with a shared genetic background.
Methods: We linked nationwide registers to identify a cohort of twin pairs born in Denmark from 1951 to 2000 (N = 31,524 pairs), where one or both twins had a diagnosis in the schizophrenia spectrum. We defined two groups consisting of; N = 788 twin pairs (affected with schizophrenia spectrum) and a subsample of N = 448 (affected with schizophrenia). Survival analysis was applied to investigate the effect of age at illness onset.
Findings: We found that early age at illness onset compared to later onset in the first diagnosed twin can be considered a major risk factor for developing schizophrenia in the second twin. Additionally, we found that the stronger genetic component in MZ twins compared to DZ twins is manifested in the proximity of assigned diagnosis within pairs.
Discussion: Early onset schizophrenia could be linked to a more severe genetic predisposition, indicating that age might be perceived as a clinical marker for genetic vulnerability for the illness. |
topic |
Twin study Age at onset Schizophrenia Nationwide register-based data |
url |
http://www.sciencedirect.com/science/article/pii/S2352396417301445 |
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