Optimized light delivery probe using ball lenses for co-registered photoacoustic and ultrasound endo-cavity subsurface imaging
An optimized hand-held photoacoustic and ultrasound probe suitable for endo-cavity tumor subsurface imaging was designed and evaluated. Compared to previous designs, the prototype probe, consisting of four 1 mm multi-mode optical fibers attached with 1.5 mm diameter ball-shaped fiber tips sandwiched...
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doaj-13dd324ca22049f3b63d59b7d906a6f52020-11-24T21:50:05ZengElsevierPhotoacoustics2213-59792019-03-01136675Optimized light delivery probe using ball lenses for co-registered photoacoustic and ultrasound endo-cavity subsurface imagingGuang Yang0Eghbal Amidi1Sreyankar Nandy2Atahar Mostafa3Quing Zhu4Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO 63130, USADepartment of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO 63130, USADepartment of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO 63130, USADepartment of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO 63130, USADepartment of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO 63130, USA; Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA; Corresponding author at: Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO 63130, USA.An optimized hand-held photoacoustic and ultrasound probe suitable for endo-cavity tumor subsurface imaging was designed and evaluated. Compared to previous designs, the prototype probe, consisting of four 1 mm multi-mode optical fibers attached with 1.5 mm diameter ball-shaped fiber tips sandwiched between a transvaginal ultrasound transducer and a custom-made sheath, demonstrated a higher light output and better beam homogeneity on tissue subsurface. The output power and fluence profile were simulated for different design parameters. A camera recorded fluence profiles through calibrated intralipid solution at various imaging depths. The light delivery efficiency was experimentally compared with and without the ball lenses, based on ex-vivo imaging of human colorectal cancer and in-vivo imaging of a palmar vein proximal to the human wrist. The simulations and experiments demonstrated that ball-shaped fiber tip design can achieve homogeneous fluence distribution on tissue subsurface with acceptable light output efficiency, suggesting its clinical potential for in-vivo endo-cavity imaging. Keywords: Photoacoustic imaging, Optimized light delivery probe, Ball-shaped fiber tip, Adenocarcinomahttp://www.sciencedirect.com/science/article/pii/S2213597918300508 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Guang Yang Eghbal Amidi Sreyankar Nandy Atahar Mostafa Quing Zhu |
spellingShingle |
Guang Yang Eghbal Amidi Sreyankar Nandy Atahar Mostafa Quing Zhu Optimized light delivery probe using ball lenses for co-registered photoacoustic and ultrasound endo-cavity subsurface imaging Photoacoustics |
author_facet |
Guang Yang Eghbal Amidi Sreyankar Nandy Atahar Mostafa Quing Zhu |
author_sort |
Guang Yang |
title |
Optimized light delivery probe using ball lenses for co-registered photoacoustic and ultrasound endo-cavity subsurface imaging |
title_short |
Optimized light delivery probe using ball lenses for co-registered photoacoustic and ultrasound endo-cavity subsurface imaging |
title_full |
Optimized light delivery probe using ball lenses for co-registered photoacoustic and ultrasound endo-cavity subsurface imaging |
title_fullStr |
Optimized light delivery probe using ball lenses for co-registered photoacoustic and ultrasound endo-cavity subsurface imaging |
title_full_unstemmed |
Optimized light delivery probe using ball lenses for co-registered photoacoustic and ultrasound endo-cavity subsurface imaging |
title_sort |
optimized light delivery probe using ball lenses for co-registered photoacoustic and ultrasound endo-cavity subsurface imaging |
publisher |
Elsevier |
series |
Photoacoustics |
issn |
2213-5979 |
publishDate |
2019-03-01 |
description |
An optimized hand-held photoacoustic and ultrasound probe suitable for endo-cavity tumor subsurface imaging was designed and evaluated. Compared to previous designs, the prototype probe, consisting of four 1 mm multi-mode optical fibers attached with 1.5 mm diameter ball-shaped fiber tips sandwiched between a transvaginal ultrasound transducer and a custom-made sheath, demonstrated a higher light output and better beam homogeneity on tissue subsurface. The output power and fluence profile were simulated for different design parameters. A camera recorded fluence profiles through calibrated intralipid solution at various imaging depths. The light delivery efficiency was experimentally compared with and without the ball lenses, based on ex-vivo imaging of human colorectal cancer and in-vivo imaging of a palmar vein proximal to the human wrist. The simulations and experiments demonstrated that ball-shaped fiber tip design can achieve homogeneous fluence distribution on tissue subsurface with acceptable light output efficiency, suggesting its clinical potential for in-vivo endo-cavity imaging. Keywords: Photoacoustic imaging, Optimized light delivery probe, Ball-shaped fiber tip, Adenocarcinoma |
url |
http://www.sciencedirect.com/science/article/pii/S2213597918300508 |
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