Mutation hotspots at CTCF binding sites coupled to chromosomal instability in gastrointestinal cancers

Mutation hotspots at CTCF binding sites coupled to chromosomal instability in gastrointestinal cancers

The impact of non-coding somatic mutations in gastric cancer is unknown. Here, using whole genome sequencing data from 212 gastric tumors, the authors identify recurring mutations at specific CTCF binding sites that are common across gastrointestinal cancers and associated with chromosomal instabili...

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Bibliographic Details
Main Authors: Yu Amanda Guo, Mei Mei Chang, Weitai Huang, Wen Fong Ooi, Manjie Xing, Patrick Tan, Anders Jacobsen Skanderup
Format: Article
Language:English
Published: Nature Publishing Group 2018-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-03828-2
Description
Summary:The impact of non-coding somatic mutations in gastric cancer is unknown. Here, using whole genome sequencing data from 212 gastric tumors, the authors identify recurring mutations at specific CTCF binding sites that are common across gastrointestinal cancers and associated with chromosomal instability.
ISSN:2041-1723

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