Mometasone furoate and fluticasone furoate are equally effective in restoring nasal epithelial barrier dysfunction in allergic rhinitis
Tight junction defects (TJ) have been associated with a defective epithelial barrier function in allergic rhinitis (AR). Intranasal corticosteroids are potent drugs frequently used to treat AR and are shown to restore epithelial integrity by acting on TJs and by reducing type 2 cytokine production....
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doaj-1425511f3c7242e1860bb362a0c7dca42021-09-13T04:13:17ZengElsevierWorld Allergy Organization Journal1939-45512021-09-01149100585Mometasone furoate and fluticasone furoate are equally effective in restoring nasal epithelial barrier dysfunction in allergic rhinitisMaria Doulaptsi0Tine Wils1Peter W. Hellings2Katleen Martens3Ricard Farré4Maria Vicario5Wytske Fokkens6Emmanuel Prokopakis7Brecht Steelant8Department of Otorhinolaryngology, Head and Neck Surgery, University of Crete School of Medicine, Heraklion, Crete, Greece.; KU Leuven Department of Microbiology, Immunology and Transplantation, Allergy and Clinical Immunology Research group, Leuven, Belgium.KU Leuven Department of Microbiology, Immunology and Transplantation, Allergy and Clinical Immunology Research group, Leuven, Belgium.KU Leuven Department of Microbiology, Immunology and Transplantation, Allergy and Clinical Immunology Research group, Leuven, Belgium.; University Hospitals Leuven, Clinical Department of Otorhinolaryngology, Head and Neck Surgery, Leuven, Belgium.; Department of Otorhinolaryngology, Academic Medical Center, Amsterdam, The Netherlands.; University of Ghent, Department of Otorhinolaryngology, Laboratory of Upper Airways Research, Ghent, Belgium.KU Leuven Department of Microbiology, Immunology and Transplantation, Allergy and Clinical Immunology Research group, Leuven, Belgium.KU Leuven, Department of Chronic Diseases, Metabolism and Ageing, Translational Research Center for Gastrointestinal Disorders, Leuven, Belgium.Digestive Diseases Research Unit, Department of Gastroenterology, Institut de Recerca Vall d’Hebron, Hospital Universitari Vall d’Hebron, Universitat Autònoma de Barcelona, Barcelona, SpainDepartment of Otorhinolaryngology, Academic Medical Center, Amsterdam, The Netherlands.Department of Otorhinolaryngology, Head and Neck Surgery, University of Crete School of Medicine, Heraklion, Crete, Greece.Department of Otorhinolaryngology, Head and Neck Surgery, University of Crete School of Medicine, Heraklion, Crete, Greece.; KU Leuven Department of Microbiology, Immunology and Transplantation, Allergy and Clinical Immunology Research group, Leuven, Belgium.; Corresponding author. KU Leuven, Allergy and Clinical Immunology Research Unit, Herestraat 49, Box 811, Leuven, Belgium.Tight junction defects (TJ) have been associated with a defective epithelial barrier function in allergic rhinitis (AR). Intranasal corticosteroids are potent drugs frequently used to treat AR and are shown to restore epithelial integrity by acting on TJs and by reducing type 2 cytokine production. However, the effect of different classes of intranasal corticosteroids on the epithelial barrier has not been studied. Therefore, we compared the effect of 2 intranasal corticosteroids, ie, fluticasone furoate (FF) and mometasone furoate (MF) on epithelial barrier function. Both FF and MF similarly increased trans-epithelial electrical resistance of primary nasal epithelial cell cultures from AR patients. In a house dust mite-induced allergic asthma mouse model, FF and MF had similar beneficial effects on fluorescein isothiocyanate–dextran 4 kDa mucosal permeability, eosinophilic infiltration and IL-13 levels. Both molecules increased mRNA expression of the TJ proteins occludin and zonula occludens-1, thereby restoring epithelial barrier function. Lastly, we showed that long-term FF treatment also increased expression of occludin in AR patients compared to controls. In conclusion, both FF and MF effectively restore epithelial barrier function by increasing expression of TJ proteins in AR patients.http://www.sciencedirect.com/science/article/pii/S193945512100079XFluticasone furoateMometasone furoateTight junctionsEpithelial integrityAllergic rhinitis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Maria Doulaptsi Tine Wils Peter W. Hellings Katleen Martens Ricard Farré Maria Vicario Wytske Fokkens Emmanuel Prokopakis Brecht Steelant |
spellingShingle |
Maria Doulaptsi Tine Wils Peter W. Hellings Katleen Martens Ricard Farré Maria Vicario Wytske Fokkens Emmanuel Prokopakis Brecht Steelant Mometasone furoate and fluticasone furoate are equally effective in restoring nasal epithelial barrier dysfunction in allergic rhinitis World Allergy Organization Journal Fluticasone furoate Mometasone furoate Tight junctions Epithelial integrity Allergic rhinitis |
author_facet |
Maria Doulaptsi Tine Wils Peter W. Hellings Katleen Martens Ricard Farré Maria Vicario Wytske Fokkens Emmanuel Prokopakis Brecht Steelant |
author_sort |
Maria Doulaptsi |
title |
Mometasone furoate and fluticasone furoate are equally effective in restoring nasal epithelial barrier dysfunction in allergic rhinitis |
title_short |
Mometasone furoate and fluticasone furoate are equally effective in restoring nasal epithelial barrier dysfunction in allergic rhinitis |
title_full |
Mometasone furoate and fluticasone furoate are equally effective in restoring nasal epithelial barrier dysfunction in allergic rhinitis |
title_fullStr |
Mometasone furoate and fluticasone furoate are equally effective in restoring nasal epithelial barrier dysfunction in allergic rhinitis |
title_full_unstemmed |
Mometasone furoate and fluticasone furoate are equally effective in restoring nasal epithelial barrier dysfunction in allergic rhinitis |
title_sort |
mometasone furoate and fluticasone furoate are equally effective in restoring nasal epithelial barrier dysfunction in allergic rhinitis |
publisher |
Elsevier |
series |
World Allergy Organization Journal |
issn |
1939-4551 |
publishDate |
2021-09-01 |
description |
Tight junction defects (TJ) have been associated with a defective epithelial barrier function in allergic rhinitis (AR). Intranasal corticosteroids are potent drugs frequently used to treat AR and are shown to restore epithelial integrity by acting on TJs and by reducing type 2 cytokine production. However, the effect of different classes of intranasal corticosteroids on the epithelial barrier has not been studied. Therefore, we compared the effect of 2 intranasal corticosteroids, ie, fluticasone furoate (FF) and mometasone furoate (MF) on epithelial barrier function. Both FF and MF similarly increased trans-epithelial electrical resistance of primary nasal epithelial cell cultures from AR patients. In a house dust mite-induced allergic asthma mouse model, FF and MF had similar beneficial effects on fluorescein isothiocyanate–dextran 4 kDa mucosal permeability, eosinophilic infiltration and IL-13 levels. Both molecules increased mRNA expression of the TJ proteins occludin and zonula occludens-1, thereby restoring epithelial barrier function. Lastly, we showed that long-term FF treatment also increased expression of occludin in AR patients compared to controls. In conclusion, both FF and MF effectively restore epithelial barrier function by increasing expression of TJ proteins in AR patients. |
topic |
Fluticasone furoate Mometasone furoate Tight junctions Epithelial integrity Allergic rhinitis |
url |
http://www.sciencedirect.com/science/article/pii/S193945512100079X |
work_keys_str_mv |
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