Oxi-Inflamm-Aging: a New Theory with Practical Implications

• Main Authors: Ángel Julio Romero Cabrera, Leocadia Amores Hernández
• Format: Article
• Language: Spanish
• Published: Centro Provincial de Información de Ciencias Médicas. Cienfuegos 2016-10-01
• Series: Medisur
• Subjects: envejecimiento; estrés oxidativo; inflamación; enfermedades crónicas; longevidad
• Online Access: http://medisur.sld.cu/index.php/medisur/article/view/3280

Oxidative stress causes an impairment of the physiological systems essential for maintaining homeostasis, including the immune system. Immune <em>dysregulation</em> leads to a <em>chronic low-grade inflammatory state</em> in aging. This is the basis of the new integrative theory called oxy-inflamm-aging. The present article describes the foundations of this theory, the current research studies that support it, and its link with the pathogenesis of some age-related diseases. It is concluded that the adoption of a healthy lifestyle from an early age can contribute to a successful aging. The benefits of caloric restriction and antioxidant supplements are still under study in order to prevent <em>oxidative stress </em>and <em>inflammation</em>, and consequently achieve greater longevity and reduce the burden of age-associated diseases.