The Effects of Xuefu Zhuyu and Shengmai on the Evolution of Syndromes and Inflammatory Markers in Patients with Unstable Angina Pectoris after Percutaneous Coronary Intervention: A Randomised Controlled Clinical Trial
We evaluated the effects of the Xuefu Zhuyu capsule (XFZY) and the Shengmai capsule (SM) on the evolution of syndromes and inflammatory markers in patients with unstable angina pectoris (UAP) after percutaneous coronary intervention (PCI). Ninety patients with UAP after PCI were randomly and equally...
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2013-01-01
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Online Access: | http://dx.doi.org/10.1155/2013/896467 |
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doaj-145cb6c845a54e14abe5bc905451dfea2020-11-25T00:11:21ZengHindawi LimitedEvidence-Based Complementary and Alternative Medicine1741-427X1741-42882013-01-01201310.1155/2013/896467896467The Effects of Xuefu Zhuyu and Shengmai on the Evolution of Syndromes and Inflammatory Markers in Patients with Unstable Angina Pectoris after Percutaneous Coronary Intervention: A Randomised Controlled Clinical TrialJie Wang0Xiaochen Yang1Fuyong Chu2Jianxin Chen3Qingyong He4Kuiwu Yao5Fei Teng6Yonghong Gao7Yanhui Xing8Aiming Wu9Yanwei Xing10Guang'anmen Hospital, Chinese Academy of Chinese Medical Sciences, Xuan Wu, Beijing 100053, ChinaGuang'anmen Hospital, Chinese Academy of Chinese Medical Sciences, Xuan Wu, Beijing 100053, ChinaBeijing Hospital of Traditional Chinese Medicine, Dong Cheng, Beijing 100010, ChinaBeijing University of Chinese Medicine, Chao Yang, Beijing 100029, ChinaGuang'anmen Hospital, Chinese Academy of Chinese Medical Sciences, Xuan Wu, Beijing 100053, ChinaGuang'anmen Hospital, Chinese Academy of Chinese Medical Sciences, Xuan Wu, Beijing 100053, ChinaGuang'anmen Hospital, Chinese Academy of Chinese Medical Sciences, Xuan Wu, Beijing 100053, ChinaThe Key Laboratory of Chinese Internal Medicine of the Ministry of Education, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Dong Cheng, Beijing 100700, ChinaInstitute of Information on Traditional Chinese Medicine, China Academy of Chinese Medical Sciences, Hai Dian, Beijing 100700, ChinaThe Key Laboratory of Chinese Internal Medicine of the Ministry of Education, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Dong Cheng, Beijing 100700, ChinaGuang'anmen Hospital, Chinese Academy of Chinese Medical Sciences, Xuan Wu, Beijing 100053, ChinaWe evaluated the effects of the Xuefu Zhuyu capsule (XFZY) and the Shengmai capsule (SM) on the evolution of syndromes and inflammatory markers in patients with unstable angina pectoris (UAP) after percutaneous coronary intervention (PCI). Ninety patients with UAP after PCI were randomly and equally assigned to three groups: the XFZY group, the SM group, and the placebo group, with 30 patients in each group. Six syndrome factors (including Qi deficiency, yin deficiency, yang deficiency, blood stasis, phlegm, and Qi stagnation) and 4 inflammatory markers (high-sensitivity C-reactive protein (Hs-CRP), endothelins-1 (ET-1), matrix metalloproteinases-9 (MMP-9), and homocysteine (Hcy)) were observed at week 0 and at the 1st, 4th and 12th weeks. In conclusion, the evolution of syndromes present in patients with UAP after PCI followed these trends (1) The deficiency syndromes gradually increased during a 12-week period, but the excess syndromes first gradually decreased and then mildly increased after PCI. (2) XFZY and SM can prevent excess syndromes from increasing in the later stages and prevent deficiency syndromes from increasing in all stages. (3) XFZY and SMcan reduce the levels of the inflammatory markers, especially in the later stages after PCI.http://dx.doi.org/10.1155/2013/896467 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jie Wang Xiaochen Yang Fuyong Chu Jianxin Chen Qingyong He Kuiwu Yao Fei Teng Yonghong Gao Yanhui Xing Aiming Wu Yanwei Xing |
spellingShingle |
Jie Wang Xiaochen Yang Fuyong Chu Jianxin Chen Qingyong He Kuiwu Yao Fei Teng Yonghong Gao Yanhui Xing Aiming Wu Yanwei Xing The Effects of Xuefu Zhuyu and Shengmai on the Evolution of Syndromes and Inflammatory Markers in Patients with Unstable Angina Pectoris after Percutaneous Coronary Intervention: A Randomised Controlled Clinical Trial Evidence-Based Complementary and Alternative Medicine |
author_facet |
Jie Wang Xiaochen Yang Fuyong Chu Jianxin Chen Qingyong He Kuiwu Yao Fei Teng Yonghong Gao Yanhui Xing Aiming Wu Yanwei Xing |
author_sort |
Jie Wang |
title |
The Effects of Xuefu Zhuyu and Shengmai on the Evolution of Syndromes and Inflammatory Markers in Patients with Unstable Angina Pectoris after Percutaneous Coronary Intervention: A Randomised Controlled Clinical Trial |
title_short |
The Effects of Xuefu Zhuyu and Shengmai on the Evolution of Syndromes and Inflammatory Markers in Patients with Unstable Angina Pectoris after Percutaneous Coronary Intervention: A Randomised Controlled Clinical Trial |
title_full |
The Effects of Xuefu Zhuyu and Shengmai on the Evolution of Syndromes and Inflammatory Markers in Patients with Unstable Angina Pectoris after Percutaneous Coronary Intervention: A Randomised Controlled Clinical Trial |
title_fullStr |
The Effects of Xuefu Zhuyu and Shengmai on the Evolution of Syndromes and Inflammatory Markers in Patients with Unstable Angina Pectoris after Percutaneous Coronary Intervention: A Randomised Controlled Clinical Trial |
title_full_unstemmed |
The Effects of Xuefu Zhuyu and Shengmai on the Evolution of Syndromes and Inflammatory Markers in Patients with Unstable Angina Pectoris after Percutaneous Coronary Intervention: A Randomised Controlled Clinical Trial |
title_sort |
effects of xuefu zhuyu and shengmai on the evolution of syndromes and inflammatory markers in patients with unstable angina pectoris after percutaneous coronary intervention: a randomised controlled clinical trial |
publisher |
Hindawi Limited |
series |
Evidence-Based Complementary and Alternative Medicine |
issn |
1741-427X 1741-4288 |
publishDate |
2013-01-01 |
description |
We evaluated the effects of the Xuefu Zhuyu capsule (XFZY) and the Shengmai capsule (SM) on the evolution of syndromes and inflammatory markers in patients with unstable angina pectoris (UAP) after percutaneous coronary intervention (PCI). Ninety patients with UAP after PCI were randomly and equally assigned to three groups: the XFZY group, the SM group, and the placebo group, with 30 patients in each group. Six syndrome factors (including Qi deficiency, yin deficiency, yang deficiency, blood stasis, phlegm, and Qi stagnation) and 4 inflammatory markers (high-sensitivity C-reactive protein (Hs-CRP), endothelins-1 (ET-1), matrix metalloproteinases-9 (MMP-9), and homocysteine (Hcy)) were observed at week 0 and at the 1st, 4th and 12th weeks. In conclusion, the evolution of syndromes present in patients with UAP after PCI followed these trends (1) The deficiency syndromes gradually increased during a 12-week period, but the excess syndromes first gradually decreased and then mildly increased after PCI. (2) XFZY and SM can prevent excess syndromes from increasing in the later stages and prevent deficiency syndromes from increasing in all stages. (3) XFZY and SMcan reduce the levels of the inflammatory markers, especially in the later stages after PCI. |
url |
http://dx.doi.org/10.1155/2013/896467 |
work_keys_str_mv |
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