Antibacterial Activity of Germacrane Type Sesquiterpenes from <i>Curcuma heyneana</i> Rhizomes
The isolation of terpenoids from C. heyneana rhizomes and their antibacterial activity have been conducted. The terpenoids were isolated by using vacuum liquid chromatography and radial chromatography. The structures of the compounds were determined based on spectroscopic data (1H-NMR, 13C-NMR (1D a...
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doaj-1461651bd57c4edc8458d0107e3d08092020-11-24T21:07:50ZengUniversitas Gadjah MadaIndonesian Journal of Chemistry1411-94202460-15782014-03-01141323610.22146/ijc.2126414362Antibacterial Activity of Germacrane Type Sesquiterpenes from <i>Curcuma heyneana</i> RhizomesHartiwi Diastuti0Yana Maolana Syah1Lia Dewi Juliawaty2Marlia Singgih3Natural Product Chemistry Group, Faculty of Mathematics and Natural Sciences, Institut Teknologi Bandung, Jl. Ganesha no. 10, Bandung 40132Natural Product Chemistry Group, Faculty of Mathematics and Natural Sciences, Institut Teknologi Bandung, Jl. Ganesha no. 10, Bandung 40132Natural Product Chemistry Group, Faculty of Mathematics and Natural Sciences, Institut Teknologi Bandung, Jl. Ganesha no. 10, Bandung 40132School of Pharmacy, Institut Teknologi Bandung, Jl. Ganesha no. 10, BandungThe isolation of terpenoids from C. heyneana rhizomes and their antibacterial activity have been conducted. The terpenoids were isolated by using vacuum liquid chromatography and radial chromatography. The structures of the compounds were determined based on spectroscopic data (1H-NMR, 13C-NMR (1D and 2D)). The antibacterial activity was carried out by using microdilution method and evaluated against eight bacteria. Three germacrane type sesquiterpenes have been isolated from C. heyneana rhizhomes and were identified as germacrone, dehydrocurdione, and 1(10),4(5)-diepoxygermacrone. Germacrone showed highest antibacterial activity against P. aeruginosa with MIC values of 15.6 µg/mL and MBC values 31.2 µg/mL. Dehydrocurdione showed highest antibacterial activity against B. subtilis with MIC values of 31.2 µg/mL and MBC values of 31.2 µg/mL. However, 1(10),4(5)-diepoxygermacrone showed a weak antibacterial activity.https://jurnal.ugm.ac.id/ijc/article/view/21264C. heyneanasesquiterpenesantibacterial |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hartiwi Diastuti Yana Maolana Syah Lia Dewi Juliawaty Marlia Singgih |
spellingShingle |
Hartiwi Diastuti Yana Maolana Syah Lia Dewi Juliawaty Marlia Singgih Antibacterial Activity of Germacrane Type Sesquiterpenes from <i>Curcuma heyneana</i> Rhizomes Indonesian Journal of Chemistry C. heyneana sesquiterpenes antibacterial |
author_facet |
Hartiwi Diastuti Yana Maolana Syah Lia Dewi Juliawaty Marlia Singgih |
author_sort |
Hartiwi Diastuti |
title |
Antibacterial Activity of Germacrane Type Sesquiterpenes from <i>Curcuma heyneana</i> Rhizomes |
title_short |
Antibacterial Activity of Germacrane Type Sesquiterpenes from <i>Curcuma heyneana</i> Rhizomes |
title_full |
Antibacterial Activity of Germacrane Type Sesquiterpenes from <i>Curcuma heyneana</i> Rhizomes |
title_fullStr |
Antibacterial Activity of Germacrane Type Sesquiterpenes from <i>Curcuma heyneana</i> Rhizomes |
title_full_unstemmed |
Antibacterial Activity of Germacrane Type Sesquiterpenes from <i>Curcuma heyneana</i> Rhizomes |
title_sort |
antibacterial activity of germacrane type sesquiterpenes from <i>curcuma heyneana</i> rhizomes |
publisher |
Universitas Gadjah Mada |
series |
Indonesian Journal of Chemistry |
issn |
1411-9420 2460-1578 |
publishDate |
2014-03-01 |
description |
The isolation of terpenoids from C. heyneana rhizomes and their antibacterial activity have been conducted. The terpenoids were isolated by using vacuum liquid chromatography and radial chromatography. The structures of the compounds were determined based on spectroscopic data (1H-NMR, 13C-NMR (1D and 2D)). The antibacterial activity was carried out by using microdilution method and evaluated against eight bacteria. Three germacrane type sesquiterpenes have been isolated from C. heyneana rhizhomes and were identified as germacrone, dehydrocurdione, and 1(10),4(5)-diepoxygermacrone. Germacrone showed highest antibacterial activity against P. aeruginosa with MIC values of 15.6 µg/mL and MBC values 31.2 µg/mL. Dehydrocurdione showed highest antibacterial activity against B. subtilis with MIC values of 31.2 µg/mL and MBC values of 31.2 µg/mL. However, 1(10),4(5)-diepoxygermacrone showed a weak antibacterial activity. |
topic |
C. heyneana sesquiterpenes antibacterial |
url |
https://jurnal.ugm.ac.id/ijc/article/view/21264 |
work_keys_str_mv |
AT hartiwidiastuti antibacterialactivityofgermacranetypesesquiterpenesfromicurcumaheyneanairhizomes AT yanamaolanasyah antibacterialactivityofgermacranetypesesquiterpenesfromicurcumaheyneanairhizomes AT liadewijuliawaty antibacterialactivityofgermacranetypesesquiterpenesfromicurcumaheyneanairhizomes AT marliasinggih antibacterialactivityofgermacranetypesesquiterpenesfromicurcumaheyneanairhizomes |
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