Chemical Diversity Investigation of Hepatotoxic Pyrrolizidine Alkaloids in Qianliguang (Senecio scandens) and Related Species by UHPLC-QTOF-MS

• Main Authors: Lin Zhu, Na Li, Jian-Qing Ruan, Peter P. Fu, Zhong-Zhen Zhao, Ge Lin
• Format: Article
• Language: English
• Published: Wolters Kluwer Medknow Publications 2015-04-01
• Series: World Journal of Traditional Chinese Medicine
• Subjects: Qianliguang (Senecio scandens); Pyrrolizidine alkaloids; UHPLC-QTOF-MS; Qualitation; Quantification
• Online Access: http://www.wjtcm.org:8080/ch/reader/create_pdf.aspx?file_no=20140010&year_id=2015&quarter_id=1&flag=1

Objective: Qianliguang (Senecio scandens) is a common Chinese medicinal herb. Qianliguang-containing herbal proprietary products are registered as over-the-counter remedies in China and exported to Western countries. The presence of hepatotoxic pyrrolizidine alkaloids (PAs) has raised concerns about the safety of using Qianliguang and its products. The present study aims at investigation of different types of PAs present in Qianliguang collected from representative locations in China.