Chinese Herbal Medicines and Active Metabolites: Potential Antioxidant Treatments for Atherosclerosis
Atherosclerosis is a complex chronic disease that occurs in the arterial wall. Oxidative stress plays a crucial role in the occurrence and progression of atherosclerotic plaques. The dominance of oxidative stress over antioxidative capacity generates excess reactive oxygen species, leading to dysfun...
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2021-05-01
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doaj-1480fe91852d49c4a26eeaf09e8949862021-05-13T09:58:15ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122021-05-011210.3389/fphar.2021.675999675999Chinese Herbal Medicines and Active Metabolites: Potential Antioxidant Treatments for AtherosclerosisLuxia Song0Luxia Song1Jie Zhang2Jie Zhang3Runmin Lai4Runmin Lai5Qiuyi Li6Qiuyi Li7Jianqing Ju8Hao Xu9Graduate School, Beijing University of Chinese Medicine, Beijing, ChinaNational Clinical Research Center for Chinese Medicine Cardiology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaGraduate School, Beijing University of Chinese Medicine, Beijing, ChinaNational Clinical Research Center for Chinese Medicine Cardiology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaGraduate School, Beijing University of Chinese Medicine, Beijing, ChinaNational Clinical Research Center for Chinese Medicine Cardiology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaGraduate School, Beijing University of Chinese Medicine, Beijing, ChinaNational Clinical Research Center for Chinese Medicine Cardiology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaNational Clinical Research Center for Chinese Medicine Cardiology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaNational Clinical Research Center for Chinese Medicine Cardiology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaAtherosclerosis is a complex chronic disease that occurs in the arterial wall. Oxidative stress plays a crucial role in the occurrence and progression of atherosclerotic plaques. The dominance of oxidative stress over antioxidative capacity generates excess reactive oxygen species, leading to dysfunctions of the endothelium and accelerating atherosclerotic plaque progression. Studies showed that Chinese herbal medicines and traditional Chinese medicine (TCM) might regulate oxidative stress; they have already been used to treat diseases related to atherosclerosis, including stroke and myocardial infarction. This review will summarize the mechanisms of oxidative stress in atherosclerosis and discuss studies of Chinese herbal medicines and TCM preparations treating atherosclerosis, aiming to increase understanding of TCM and stimulate research for new drugs to treat diseases associated with oxidative stress.https://www.frontiersin.org/articles/10.3389/fphar.2021.675999/fulloxidative stressatherosclerosisanti-oxidant treatmenttraditional Chinese medicineChinese herbal medicines |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Luxia Song Luxia Song Jie Zhang Jie Zhang Runmin Lai Runmin Lai Qiuyi Li Qiuyi Li Jianqing Ju Hao Xu |
spellingShingle |
Luxia Song Luxia Song Jie Zhang Jie Zhang Runmin Lai Runmin Lai Qiuyi Li Qiuyi Li Jianqing Ju Hao Xu Chinese Herbal Medicines and Active Metabolites: Potential Antioxidant Treatments for Atherosclerosis Frontiers in Pharmacology oxidative stress atherosclerosis anti-oxidant treatment traditional Chinese medicine Chinese herbal medicines |
author_facet |
Luxia Song Luxia Song Jie Zhang Jie Zhang Runmin Lai Runmin Lai Qiuyi Li Qiuyi Li Jianqing Ju Hao Xu |
author_sort |
Luxia Song |
title |
Chinese Herbal Medicines and Active Metabolites: Potential Antioxidant Treatments for Atherosclerosis |
title_short |
Chinese Herbal Medicines and Active Metabolites: Potential Antioxidant Treatments for Atherosclerosis |
title_full |
Chinese Herbal Medicines and Active Metabolites: Potential Antioxidant Treatments for Atherosclerosis |
title_fullStr |
Chinese Herbal Medicines and Active Metabolites: Potential Antioxidant Treatments for Atherosclerosis |
title_full_unstemmed |
Chinese Herbal Medicines and Active Metabolites: Potential Antioxidant Treatments for Atherosclerosis |
title_sort |
chinese herbal medicines and active metabolites: potential antioxidant treatments for atherosclerosis |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Pharmacology |
issn |
1663-9812 |
publishDate |
2021-05-01 |
description |
Atherosclerosis is a complex chronic disease that occurs in the arterial wall. Oxidative stress plays a crucial role in the occurrence and progression of atherosclerotic plaques. The dominance of oxidative stress over antioxidative capacity generates excess reactive oxygen species, leading to dysfunctions of the endothelium and accelerating atherosclerotic plaque progression. Studies showed that Chinese herbal medicines and traditional Chinese medicine (TCM) might regulate oxidative stress; they have already been used to treat diseases related to atherosclerosis, including stroke and myocardial infarction. This review will summarize the mechanisms of oxidative stress in atherosclerosis and discuss studies of Chinese herbal medicines and TCM preparations treating atherosclerosis, aiming to increase understanding of TCM and stimulate research for new drugs to treat diseases associated with oxidative stress. |
topic |
oxidative stress atherosclerosis anti-oxidant treatment traditional Chinese medicine Chinese herbal medicines |
url |
https://www.frontiersin.org/articles/10.3389/fphar.2021.675999/full |
work_keys_str_mv |
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