Dengue Virus Glycosylation: What Do We Know?
In many infectious diseases caused by either viruses or bacteria, pathogen glycoproteins play important roles during the infection cycle, ranging from entry to successful intracellular replication and host immune evasion. Dengue is no exception. Dengue virus glycoproteins, envelope protein (E) and n...
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doaj-149b0f979cec4c3dbf94bfd6643fa5f22020-11-24T21:36:04ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2017-07-01810.3389/fmicb.2017.01415283239Dengue Virus Glycosylation: What Do We Know?Sally S. L. Yap0Terry Nguyen-Khuong1Pauline M. Rudd2Sylvie Alonso3Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, and Immunology program, Life Sciences Institute, National University of SingaporeSingapore, SingaporeAnalytics Group, Bioprocessing Technology Institute, A∗STARSingapore, SingaporeAnalytics Group, Bioprocessing Technology Institute, A∗STARSingapore, SingaporeDepartment of Microbiology and Immunology, Yong Loo Lin School of Medicine, and Immunology program, Life Sciences Institute, National University of SingaporeSingapore, SingaporeIn many infectious diseases caused by either viruses or bacteria, pathogen glycoproteins play important roles during the infection cycle, ranging from entry to successful intracellular replication and host immune evasion. Dengue is no exception. Dengue virus glycoproteins, envelope protein (E) and non-structural protein 1 (NS1) are two popular sub-unit vaccine candidates. E protein on the virion surface is the major target of neutralizing antibodies. NS1 which is secreted during DENV infection has been shown to induce a variety of host responses through its binding to several host factors. However, despite their critical role in disease and protection, the glycosylated variants of these two proteins and their biological importance have remained understudied. In this review, we seek to provide a comprehensive summary of the current knowledge on protein glycosylation in DENV, and its role in virus biogenesis, host cell receptor interaction and disease pathogenesis.http://journal.frontiersin.org/article/10.3389/fmicb.2017.01415/fulldengue virusglycosylationglycomicsE proteinNS1 protein |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sally S. L. Yap Terry Nguyen-Khuong Pauline M. Rudd Sylvie Alonso |
spellingShingle |
Sally S. L. Yap Terry Nguyen-Khuong Pauline M. Rudd Sylvie Alonso Dengue Virus Glycosylation: What Do We Know? Frontiers in Microbiology dengue virus glycosylation glycomics E protein NS1 protein |
author_facet |
Sally S. L. Yap Terry Nguyen-Khuong Pauline M. Rudd Sylvie Alonso |
author_sort |
Sally S. L. Yap |
title |
Dengue Virus Glycosylation: What Do We Know? |
title_short |
Dengue Virus Glycosylation: What Do We Know? |
title_full |
Dengue Virus Glycosylation: What Do We Know? |
title_fullStr |
Dengue Virus Glycosylation: What Do We Know? |
title_full_unstemmed |
Dengue Virus Glycosylation: What Do We Know? |
title_sort |
dengue virus glycosylation: what do we know? |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Microbiology |
issn |
1664-302X |
publishDate |
2017-07-01 |
description |
In many infectious diseases caused by either viruses or bacteria, pathogen glycoproteins play important roles during the infection cycle, ranging from entry to successful intracellular replication and host immune evasion. Dengue is no exception. Dengue virus glycoproteins, envelope protein (E) and non-structural protein 1 (NS1) are two popular sub-unit vaccine candidates. E protein on the virion surface is the major target of neutralizing antibodies. NS1 which is secreted during DENV infection has been shown to induce a variety of host responses through its binding to several host factors. However, despite their critical role in disease and protection, the glycosylated variants of these two proteins and their biological importance have remained understudied. In this review, we seek to provide a comprehensive summary of the current knowledge on protein glycosylation in DENV, and its role in virus biogenesis, host cell receptor interaction and disease pathogenesis. |
topic |
dengue virus glycosylation glycomics E protein NS1 protein |
url |
http://journal.frontiersin.org/article/10.3389/fmicb.2017.01415/full |
work_keys_str_mv |
AT sallyslyap denguevirusglycosylationwhatdoweknow AT terrynguyenkhuong denguevirusglycosylationwhatdoweknow AT paulinemrudd denguevirusglycosylationwhatdoweknow AT sylviealonso denguevirusglycosylationwhatdoweknow |
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1725942390191030272 |