Recent transmission of drug-resistant Mycobacterium tuberculosis in a prison population in southern Brazil
ABSTRACT We conducted a cross-sectional, retrospective study, characterized by classical and molecular epidemiology, involving M. tuberculosis isolates from a regional prison in southern Brazil. Between January of 2011 and August of 2014, 379 prisoners underwent sputum smear microscopy and culture;...
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Sociedade Brasileira de Pneumologia e Tisiologia
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doaj-14a5b2cfb01c480980684b183aec77cb2020-11-24T23:39:38ZengSociedade Brasileira de Pneumologia e TisiologiaJornal Brasileiro de Pneumologia1806-375642428628910.1590/S1806-37562016000000023S1806-37132016000400286Recent transmission of drug-resistant Mycobacterium tuberculosis in a prison population in southern BrazilAna Julia ReisSimone Maria Martini de DavidLuciana de Souza NunesAndreia Rosane de Moura ValimLia Gonçalves PossueloABSTRACT We conducted a cross-sectional, retrospective study, characterized by classical and molecular epidemiology, involving M. tuberculosis isolates from a regional prison in southern Brazil. Between January of 2011 and August of 2014, 379 prisoners underwent sputum smear microscopy and culture; 53 (13.9%) were diagnosed with active tuberculosis. Of those, 8 (22.9%) presented with isoniazid-resistant tuberculosis. Strain genotyping was carried out by 15-locus mycobacterial interspersed repetitive unit-variable-number tandem-repeat analysis; 68.6% of the patients were distributed into five clusters, and 87.5% of the resistant cases were in the same cluster. The frequency of drug-resistant tuberculosis cases and the rate of recent transmission were high. Our data suggest the need to implement an effective tuberculosis control program within the prison system.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1806-37132016000400286&lng=en&tlng=enTuberculosisPrisonsMolecular epidemiology |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ana Julia Reis Simone Maria Martini de David Luciana de Souza Nunes Andreia Rosane de Moura Valim Lia Gonçalves Possuelo |
spellingShingle |
Ana Julia Reis Simone Maria Martini de David Luciana de Souza Nunes Andreia Rosane de Moura Valim Lia Gonçalves Possuelo Recent transmission of drug-resistant Mycobacterium tuberculosis in a prison population in southern Brazil Jornal Brasileiro de Pneumologia Tuberculosis Prisons Molecular epidemiology |
author_facet |
Ana Julia Reis Simone Maria Martini de David Luciana de Souza Nunes Andreia Rosane de Moura Valim Lia Gonçalves Possuelo |
author_sort |
Ana Julia Reis |
title |
Recent transmission of drug-resistant Mycobacterium tuberculosis in a prison population in southern Brazil |
title_short |
Recent transmission of drug-resistant Mycobacterium tuberculosis in a prison population in southern Brazil |
title_full |
Recent transmission of drug-resistant Mycobacterium tuberculosis in a prison population in southern Brazil |
title_fullStr |
Recent transmission of drug-resistant Mycobacterium tuberculosis in a prison population in southern Brazil |
title_full_unstemmed |
Recent transmission of drug-resistant Mycobacterium tuberculosis in a prison population in southern Brazil |
title_sort |
recent transmission of drug-resistant mycobacterium tuberculosis in a prison population in southern brazil |
publisher |
Sociedade Brasileira de Pneumologia e Tisiologia |
series |
Jornal Brasileiro de Pneumologia |
issn |
1806-3756 |
description |
ABSTRACT We conducted a cross-sectional, retrospective study, characterized by classical and molecular epidemiology, involving M. tuberculosis isolates from a regional prison in southern Brazil. Between January of 2011 and August of 2014, 379 prisoners underwent sputum smear microscopy and culture; 53 (13.9%) were diagnosed with active tuberculosis. Of those, 8 (22.9%) presented with isoniazid-resistant tuberculosis. Strain genotyping was carried out by 15-locus mycobacterial interspersed repetitive unit-variable-number tandem-repeat analysis; 68.6% of the patients were distributed into five clusters, and 87.5% of the resistant cases were in the same cluster. The frequency of drug-resistant tuberculosis cases and the rate of recent transmission were high. Our data suggest the need to implement an effective tuberculosis control program within the prison system. |
topic |
Tuberculosis Prisons Molecular epidemiology |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1806-37132016000400286&lng=en&tlng=en |
work_keys_str_mv |
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