Contribution of Pro-Inflammatory Cytokine Signaling within Midbrain Periaqueductal Gray to Pain Sensitivity in Parkinson's disease via GABAergic Pathway

Contribution of Pro-Inflammatory Cytokine Signaling within Midbrain Periaqueductal Gray to Pain Sensitivity in Parkinson's disease via GABAergic Pathway

Background/Aims: Hypersensitive pain response is often observed in patients with Parkinson's disease (PD); however, the mechanisms responsible for hyperalgesia are not well understood. Chronic neuroinflammation is one of the hallmarks of PD pathophysiology. Since the midbrain periaqueductal gra...

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Bibliographic Details
Main Authors: Xianbo Zhuang, Yanxiu Chen, Xianpeng Zhuang, Tuanzhi Chen, Tao Xing, Weifei Wang, Xiafeng Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-07-01
Series:Frontiers in Neurology
Subjects:
Cytokines
Inflammation Mediators
Pain Threshold
Parkinsonian Disorders
midbrain central gray
Parkinson's disease; cytokines; pain sensitivity; midbrain PAG
Online Access:http://journal.frontiersin.org/Journal/10.3389/fneur.2016.00104/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fneur.2016.00104/full

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