Subchronic Toxicity Study of Standardized Methanolic Extract of Mitragyna Speciosa Korth in Sprague-Dawley Rats
Mitragyna speciosa Korth, or better known as ketum, has long been used by traditional folk around Southeast Asia to prevent fatigue from working under hot tropical weather and as a replacement of opium, which can then cause addiction. To date, no findings have been reported of the toxic...
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doaj-14b8a5845af74e3e92b1cb1a2288ef102020-11-25T00:21:41ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2015-06-01910.3389/fnins.2015.00189133864Subchronic Toxicity Study of Standardized Methanolic Extract of Mitragyna Speciosa Korth in Sprague-Dawley RatsMohd Ulul Ilmie Ahmad Nazri0Hasnan eJaafar1Sharif Mahsufi Mansor2Jafri Malin Abdullah3Jafri Malin Abdullah4Jafri Malin Abdullah5Universiti Sains MalaysiaUniversiti Sains MalaysiaUniversiti Sains MalaysiaUniversiti Sains MalaysiaUniversiti Sains MalaysiaHospital Universiti Sains MalaysiaMitragyna speciosa Korth, or better known as ketum, has long been used by traditional folk around Southeast Asia to prevent fatigue from working under hot tropical weather and as a replacement of opium, which can then cause addiction. To date, no findings have been reported of the toxic effect of ketum subchronically (28 days). Hence, the aim of this study was to investigate the toxicity of subchronic effect of standardised methanolic extract of ketum (SMEMS) in Sprague-Dawley rats. Rats were orally administered with 100, 200, and 500 mg/kg of SMEMS for 28 days. Body weights were recorded daily. They were terminated at day 28 to obtain data for haematology, biochemistry, and histopathology of the brain, liver, kidney, lung, heart, sciatic nerve, and spinal cord. The SMEMS affected body weight compared to control group. Biochemistry findings showed that liver and kidney were affected with the abnormal values in AST, creatinine, globulin, glucose, total protein, and urea. However, SMEMS produced toxic effect more to liver, kidney, and lung than other organs as observed histopathologically. The results suggested subchronic exposure of ketum is toxic to the physiology of the animals.http://journal.frontiersin.org/Journal/10.3389/fnins.2015.00189/fullMitragyna speciosaSprague-Dawley ratoral administrationSubchronic toxicityStandardised methanolic extract |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mohd Ulul Ilmie Ahmad Nazri Hasnan eJaafar Sharif Mahsufi Mansor Jafri Malin Abdullah Jafri Malin Abdullah Jafri Malin Abdullah |
spellingShingle |
Mohd Ulul Ilmie Ahmad Nazri Hasnan eJaafar Sharif Mahsufi Mansor Jafri Malin Abdullah Jafri Malin Abdullah Jafri Malin Abdullah Subchronic Toxicity Study of Standardized Methanolic Extract of Mitragyna Speciosa Korth in Sprague-Dawley Rats Frontiers in Neuroscience Mitragyna speciosa Sprague-Dawley rat oral administration Subchronic toxicity Standardised methanolic extract |
author_facet |
Mohd Ulul Ilmie Ahmad Nazri Hasnan eJaafar Sharif Mahsufi Mansor Jafri Malin Abdullah Jafri Malin Abdullah Jafri Malin Abdullah |
author_sort |
Mohd Ulul Ilmie Ahmad Nazri |
title |
Subchronic Toxicity Study of Standardized Methanolic Extract of Mitragyna Speciosa Korth in Sprague-Dawley Rats |
title_short |
Subchronic Toxicity Study of Standardized Methanolic Extract of Mitragyna Speciosa Korth in Sprague-Dawley Rats |
title_full |
Subchronic Toxicity Study of Standardized Methanolic Extract of Mitragyna Speciosa Korth in Sprague-Dawley Rats |
title_fullStr |
Subchronic Toxicity Study of Standardized Methanolic Extract of Mitragyna Speciosa Korth in Sprague-Dawley Rats |
title_full_unstemmed |
Subchronic Toxicity Study of Standardized Methanolic Extract of Mitragyna Speciosa Korth in Sprague-Dawley Rats |
title_sort |
subchronic toxicity study of standardized methanolic extract of mitragyna speciosa korth in sprague-dawley rats |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Neuroscience |
issn |
1662-453X |
publishDate |
2015-06-01 |
description |
Mitragyna speciosa Korth, or better known as ketum, has long been used by traditional folk around Southeast Asia to prevent fatigue from working under hot tropical weather and as a replacement of opium, which can then cause addiction. To date, no findings have been reported of the toxic effect of ketum subchronically (28 days). Hence, the aim of this study was to investigate the toxicity of subchronic effect of standardised methanolic extract of ketum (SMEMS) in Sprague-Dawley rats. Rats were orally administered with 100, 200, and 500 mg/kg of SMEMS for 28 days. Body weights were recorded daily. They were terminated at day 28 to obtain data for haematology, biochemistry, and histopathology of the brain, liver, kidney, lung, heart, sciatic nerve, and spinal cord. The SMEMS affected body weight compared to control group. Biochemistry findings showed that liver and kidney were affected with the abnormal values in AST, creatinine, globulin, glucose, total protein, and urea. However, SMEMS produced toxic effect more to liver, kidney, and lung than other organs as observed histopathologically. The results suggested subchronic exposure of ketum is toxic to the physiology of the animals. |
topic |
Mitragyna speciosa Sprague-Dawley rat oral administration Subchronic toxicity Standardised methanolic extract |
url |
http://journal.frontiersin.org/Journal/10.3389/fnins.2015.00189/full |
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