Promising Clinical Outcome With Long Term Follow-Up After Body Gamma Knife Stereotactic Radiosurgery for Patients With Early Stage Non-small Cell Lung Cancer
Introduction: Stereotactic ablative radiosurgery (SRS) or stereotactic ablative body radiotherapy (SABR) is the standard treatment for patients with inoperable early stage non-small cell lung cancer (NSCLC), the body gamma knife SRS (ɤ-SRS) is a special SABR technology developed in China. This study...
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doaj-14bbcfb83a10436287d476072c70f8442020-11-25T00:45:51ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2018-12-01810.3389/fonc.2018.00618428612Promising Clinical Outcome With Long Term Follow-Up After Body Gamma Knife Stereotactic Radiosurgery for Patients With Early Stage Non-small Cell Lung CancerHongqi Li0Hongqi Li1Jing Li2Jing Li3Xuan Wang4Haifeng Pang5Yupeng Di6Gang Ren7Ping Li8Chen Liu9Xiao Chen10Xiaoli Kang11Yingjie Wang12Tingyi Xia13Department of Radiation Oncology, Airforce General Hospital PLA, Beijing, ChinaMedical School, People's Liberation Army General Hospital, Beijing, ChinaDepartment of Radiation Oncology, Airforce General Hospital PLA, Beijing, ChinaMedical School, People's Liberation Army General Hospital, Beijing, ChinaDepartment of Radiation Oncology, Airforce General Hospital PLA, Beijing, ChinaDepartment of Radiation Oncology, Airforce General Hospital PLA, Beijing, ChinaDepartment of Radiation Oncology, Airforce General Hospital PLA, Beijing, ChinaDepartment of Radiation Oncology, Airforce General Hospital PLA, Beijing, ChinaDepartment of Radiation Oncology, Airforce General Hospital PLA, Beijing, ChinaDepartment of Radiation Oncology, Airforce General Hospital PLA, Beijing, ChinaDepartment of Radiation Oncology, Airforce General Hospital PLA, Beijing, ChinaDepartment of Radiation Oncology, Airforce General Hospital PLA, Beijing, ChinaDepartment of Radiation Oncology, Airforce General Hospital PLA, Beijing, ChinaDepartment of Radiation Oncology, Airforce General Hospital PLA, Beijing, ChinaIntroduction: Stereotactic ablative radiosurgery (SRS) or stereotactic ablative body radiotherapy (SABR) is the standard treatment for patients with inoperable early stage non-small cell lung cancer (NSCLC), the body gamma knife SRS (ɤ-SRS) is a special SABR technology developed in China. This study prospectively assessed the clinical outcome, toxicity and cost following body ɤ-SRS for early stage NSCLC.Methods: From 2007 to 2010, a total of 29 patients with early stage NSCLC were prospectively enrolled in this study. The prescription dose for Planning Target Volume (PTV), Clinical Target Volume (CTV), and Gross Target Volume (GTV) were 50, 60, and 70 gray (Gy) in 10 fractions. Isodose curves of 50, 60, and 70% covered at least 100% of PTV, 90% of CTV, and 80% of GTV, respectively. The body ɤ-SRS was delivered 5 days per week and completed in 2 weeks.Results: Median follow-up time was 62.0 (range 11.1-140.3) months. 1-, 3-, 5-year OS rates were 93.1%, 72.0%, 60.3%; PFS rates were 86.2, 64.2 and 48.8%; and LR, RR, and DM rates were 10.9%, 21.4%, 29.0%. The median cost of the body ɤ-SRS during treatment was 4,838 (range 4,615–4,923) dollars and the median cost through 5 years was 36,960 (range 9920-56,824) dollars.Conclusion: With existing clinical data, the body ɤ-SRS is an effective treatment option for patients with medically inoperable early stage NSCLC or patients who do not prefer operation, as they may benefit from the minimized toxicity. Due to excellent cost effectiveness, the availability of the body ɤ-SRS will expand, especially in developing nations, and underdeveloped countries.https://www.frontiersin.org/article/10.3389/fonc.2018.00618/fullearly stage lung cancernon-small cell lung cancerbody gamma knifestereotactic body radiotherapy (SBRT)stereotactic ablative radiation therapy (SABR)stereotactic radiosurgery (SRS) |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hongqi Li Hongqi Li Jing Li Jing Li Xuan Wang Haifeng Pang Yupeng Di Gang Ren Ping Li Chen Liu Xiao Chen Xiaoli Kang Yingjie Wang Tingyi Xia |
spellingShingle |
Hongqi Li Hongqi Li Jing Li Jing Li Xuan Wang Haifeng Pang Yupeng Di Gang Ren Ping Li Chen Liu Xiao Chen Xiaoli Kang Yingjie Wang Tingyi Xia Promising Clinical Outcome With Long Term Follow-Up After Body Gamma Knife Stereotactic Radiosurgery for Patients With Early Stage Non-small Cell Lung Cancer Frontiers in Oncology early stage lung cancer non-small cell lung cancer body gamma knife stereotactic body radiotherapy (SBRT) stereotactic ablative radiation therapy (SABR) stereotactic radiosurgery (SRS) |
author_facet |
Hongqi Li Hongqi Li Jing Li Jing Li Xuan Wang Haifeng Pang Yupeng Di Gang Ren Ping Li Chen Liu Xiao Chen Xiaoli Kang Yingjie Wang Tingyi Xia |
author_sort |
Hongqi Li |
title |
Promising Clinical Outcome With Long Term Follow-Up After Body Gamma Knife Stereotactic Radiosurgery for Patients With Early Stage Non-small Cell Lung Cancer |
title_short |
Promising Clinical Outcome With Long Term Follow-Up After Body Gamma Knife Stereotactic Radiosurgery for Patients With Early Stage Non-small Cell Lung Cancer |
title_full |
Promising Clinical Outcome With Long Term Follow-Up After Body Gamma Knife Stereotactic Radiosurgery for Patients With Early Stage Non-small Cell Lung Cancer |
title_fullStr |
Promising Clinical Outcome With Long Term Follow-Up After Body Gamma Knife Stereotactic Radiosurgery for Patients With Early Stage Non-small Cell Lung Cancer |
title_full_unstemmed |
Promising Clinical Outcome With Long Term Follow-Up After Body Gamma Knife Stereotactic Radiosurgery for Patients With Early Stage Non-small Cell Lung Cancer |
title_sort |
promising clinical outcome with long term follow-up after body gamma knife stereotactic radiosurgery for patients with early stage non-small cell lung cancer |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Oncology |
issn |
2234-943X |
publishDate |
2018-12-01 |
description |
Introduction: Stereotactic ablative radiosurgery (SRS) or stereotactic ablative body radiotherapy (SABR) is the standard treatment for patients with inoperable early stage non-small cell lung cancer (NSCLC), the body gamma knife SRS (ɤ-SRS) is a special SABR technology developed in China. This study prospectively assessed the clinical outcome, toxicity and cost following body ɤ-SRS for early stage NSCLC.Methods: From 2007 to 2010, a total of 29 patients with early stage NSCLC were prospectively enrolled in this study. The prescription dose for Planning Target Volume (PTV), Clinical Target Volume (CTV), and Gross Target Volume (GTV) were 50, 60, and 70 gray (Gy) in 10 fractions. Isodose curves of 50, 60, and 70% covered at least 100% of PTV, 90% of CTV, and 80% of GTV, respectively. The body ɤ-SRS was delivered 5 days per week and completed in 2 weeks.Results: Median follow-up time was 62.0 (range 11.1-140.3) months. 1-, 3-, 5-year OS rates were 93.1%, 72.0%, 60.3%; PFS rates were 86.2, 64.2 and 48.8%; and LR, RR, and DM rates were 10.9%, 21.4%, 29.0%. The median cost of the body ɤ-SRS during treatment was 4,838 (range 4,615–4,923) dollars and the median cost through 5 years was 36,960 (range 9920-56,824) dollars.Conclusion: With existing clinical data, the body ɤ-SRS is an effective treatment option for patients with medically inoperable early stage NSCLC or patients who do not prefer operation, as they may benefit from the minimized toxicity. Due to excellent cost effectiveness, the availability of the body ɤ-SRS will expand, especially in developing nations, and underdeveloped countries. |
topic |
early stage lung cancer non-small cell lung cancer body gamma knife stereotactic body radiotherapy (SBRT) stereotactic ablative radiation therapy (SABR) stereotactic radiosurgery (SRS) |
url |
https://www.frontiersin.org/article/10.3389/fonc.2018.00618/full |
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