Docosahexaenoic Acid-Acylated Astaxanthin Esters Exhibit Superior Renal Protective Effect to Recombination of Astaxanthin with DHA via Alleviating Oxidative Stress Coupled with Apoptosis in Vancomycin-Treated Mice with Nephrotoxicity
Prevention of acute kidney injury caused by drugs is still a clinical problem to be solved urgently. Astaxanthin (AST) and docosahexaenoic acid (DHA) are important marine-derived active ingredients, and they are reported to exhibit renal protective activity. It is noteworthy that the existing forms...
Main Authors: | , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2021-08-01
|
Series: | Marine Drugs |
Subjects: | |
Online Access: | https://www.mdpi.com/1660-3397/19/9/499 |
id |
doaj-14bbede365844df9b124a651581896ec |
---|---|
record_format |
Article |
spelling |
doaj-14bbede365844df9b124a651581896ec2021-09-26T00:35:30ZengMDPI AGMarine Drugs1660-33972021-08-011949949910.3390/md19090499Docosahexaenoic Acid-Acylated Astaxanthin Esters Exhibit Superior Renal Protective Effect to Recombination of Astaxanthin with DHA via Alleviating Oxidative Stress Coupled with Apoptosis in Vancomycin-Treated Mice with NephrotoxicityHao-Hao Shi0Ying Guo1Li-Pin Chen2Cheng-Cheng Wang3Qing-Rong Huang4Chang-Hu Xue5Yu-Ming Wang6Tian-Tian Zhang7College of Food Science and Engineering, Ocean University of China, Qingdao 266003, ChinaCollege of Food Science and Engineering, Ocean University of China, Qingdao 266003, ChinaCollege of Food Science and Engineering, Ocean University of China, Qingdao 266003, ChinaCollege of Food Science and Engineering, Ocean University of China, Qingdao 266003, ChinaDepartment of Food Science, The State University of New Jersey, Rutgers, 65 Dudley Road, New Brunswick, NJ 08901, USACollege of Food Science and Engineering, Ocean University of China, Qingdao 266003, ChinaCollege of Food Science and Engineering, Ocean University of China, Qingdao 266003, ChinaCollege of Food Science and Engineering, Ocean University of China, Qingdao 266003, ChinaPrevention of acute kidney injury caused by drugs is still a clinical problem to be solved urgently. Astaxanthin (AST) and docosahexaenoic acid (DHA) are important marine-derived active ingredients, and they are reported to exhibit renal protective activity. It is noteworthy that the existing forms of AST in nature are mainly fatty acid-acylated AST monoesters and diesters, as well as unesterified AST, in which DHA is an esterified fatty acid. However, no reports focus on the different bioactivities of unesterified AST, monoesters and diesters, as well as the recombination of DHA and unesterified AST on nephrotoxicity. In the present study, vancomycin-treated mice were used to evaluate the effects of DHA-acylated AST monoesters, DHA-acylated AST diesters, unesterified AST, and the recombination of AST and DHA in alleviating nephrotoxicity by determining serum biochemical index, histopathological changes, and the enzyme activity related to oxidative stress. Results found that the intervention of DHA-acylated AST diesters significantly ameliorated kidney dysfunction by decreasing the levels of urea nitrogen and creatinine, alleviating pathological damage and oxidative stress compared to AST monoester, unesterified AST, and the recombination of AST and DHA. Further studies revealed that dietary DHA-acylated AST esters could inhibit the activation of the caspase cascade and MAPKs signaling pathway, and reduce the levels of pro-inflammatory cytokines. These findings indicated that the administration of DHA-acylated AST esters could alleviate vancomycin-induced nephrotoxicity, which represented a potentially novel candidate or therapeutic adjuvant for alleviating acute kidney injury.https://www.mdpi.com/1660-3397/19/9/499nephrotoxicityastaxanthinDHAmonoestersdiesters |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hao-Hao Shi Ying Guo Li-Pin Chen Cheng-Cheng Wang Qing-Rong Huang Chang-Hu Xue Yu-Ming Wang Tian-Tian Zhang |
spellingShingle |
Hao-Hao Shi Ying Guo Li-Pin Chen Cheng-Cheng Wang Qing-Rong Huang Chang-Hu Xue Yu-Ming Wang Tian-Tian Zhang Docosahexaenoic Acid-Acylated Astaxanthin Esters Exhibit Superior Renal Protective Effect to Recombination of Astaxanthin with DHA via Alleviating Oxidative Stress Coupled with Apoptosis in Vancomycin-Treated Mice with Nephrotoxicity Marine Drugs nephrotoxicity astaxanthin DHA monoesters diesters |
author_facet |
Hao-Hao Shi Ying Guo Li-Pin Chen Cheng-Cheng Wang Qing-Rong Huang Chang-Hu Xue Yu-Ming Wang Tian-Tian Zhang |
author_sort |
Hao-Hao Shi |
title |
Docosahexaenoic Acid-Acylated Astaxanthin Esters Exhibit Superior Renal Protective Effect to Recombination of Astaxanthin with DHA via Alleviating Oxidative Stress Coupled with Apoptosis in Vancomycin-Treated Mice with Nephrotoxicity |
title_short |
Docosahexaenoic Acid-Acylated Astaxanthin Esters Exhibit Superior Renal Protective Effect to Recombination of Astaxanthin with DHA via Alleviating Oxidative Stress Coupled with Apoptosis in Vancomycin-Treated Mice with Nephrotoxicity |
title_full |
Docosahexaenoic Acid-Acylated Astaxanthin Esters Exhibit Superior Renal Protective Effect to Recombination of Astaxanthin with DHA via Alleviating Oxidative Stress Coupled with Apoptosis in Vancomycin-Treated Mice with Nephrotoxicity |
title_fullStr |
Docosahexaenoic Acid-Acylated Astaxanthin Esters Exhibit Superior Renal Protective Effect to Recombination of Astaxanthin with DHA via Alleviating Oxidative Stress Coupled with Apoptosis in Vancomycin-Treated Mice with Nephrotoxicity |
title_full_unstemmed |
Docosahexaenoic Acid-Acylated Astaxanthin Esters Exhibit Superior Renal Protective Effect to Recombination of Astaxanthin with DHA via Alleviating Oxidative Stress Coupled with Apoptosis in Vancomycin-Treated Mice with Nephrotoxicity |
title_sort |
docosahexaenoic acid-acylated astaxanthin esters exhibit superior renal protective effect to recombination of astaxanthin with dha via alleviating oxidative stress coupled with apoptosis in vancomycin-treated mice with nephrotoxicity |
publisher |
MDPI AG |
series |
Marine Drugs |
issn |
1660-3397 |
publishDate |
2021-08-01 |
description |
Prevention of acute kidney injury caused by drugs is still a clinical problem to be solved urgently. Astaxanthin (AST) and docosahexaenoic acid (DHA) are important marine-derived active ingredients, and they are reported to exhibit renal protective activity. It is noteworthy that the existing forms of AST in nature are mainly fatty acid-acylated AST monoesters and diesters, as well as unesterified AST, in which DHA is an esterified fatty acid. However, no reports focus on the different bioactivities of unesterified AST, monoesters and diesters, as well as the recombination of DHA and unesterified AST on nephrotoxicity. In the present study, vancomycin-treated mice were used to evaluate the effects of DHA-acylated AST monoesters, DHA-acylated AST diesters, unesterified AST, and the recombination of AST and DHA in alleviating nephrotoxicity by determining serum biochemical index, histopathological changes, and the enzyme activity related to oxidative stress. Results found that the intervention of DHA-acylated AST diesters significantly ameliorated kidney dysfunction by decreasing the levels of urea nitrogen and creatinine, alleviating pathological damage and oxidative stress compared to AST monoester, unesterified AST, and the recombination of AST and DHA. Further studies revealed that dietary DHA-acylated AST esters could inhibit the activation of the caspase cascade and MAPKs signaling pathway, and reduce the levels of pro-inflammatory cytokines. These findings indicated that the administration of DHA-acylated AST esters could alleviate vancomycin-induced nephrotoxicity, which represented a potentially novel candidate or therapeutic adjuvant for alleviating acute kidney injury. |
topic |
nephrotoxicity astaxanthin DHA monoesters diesters |
url |
https://www.mdpi.com/1660-3397/19/9/499 |
work_keys_str_mv |
AT haohaoshi docosahexaenoicacidacylatedastaxanthinestersexhibitsuperiorrenalprotectiveeffecttorecombinationofastaxanthinwithdhaviaalleviatingoxidativestresscoupledwithapoptosisinvancomycintreatedmicewithnephrotoxicity AT yingguo docosahexaenoicacidacylatedastaxanthinestersexhibitsuperiorrenalprotectiveeffecttorecombinationofastaxanthinwithdhaviaalleviatingoxidativestresscoupledwithapoptosisinvancomycintreatedmicewithnephrotoxicity AT lipinchen docosahexaenoicacidacylatedastaxanthinestersexhibitsuperiorrenalprotectiveeffecttorecombinationofastaxanthinwithdhaviaalleviatingoxidativestresscoupledwithapoptosisinvancomycintreatedmicewithnephrotoxicity AT chengchengwang docosahexaenoicacidacylatedastaxanthinestersexhibitsuperiorrenalprotectiveeffecttorecombinationofastaxanthinwithdhaviaalleviatingoxidativestresscoupledwithapoptosisinvancomycintreatedmicewithnephrotoxicity AT qingronghuang docosahexaenoicacidacylatedastaxanthinestersexhibitsuperiorrenalprotectiveeffecttorecombinationofastaxanthinwithdhaviaalleviatingoxidativestresscoupledwithapoptosisinvancomycintreatedmicewithnephrotoxicity AT changhuxue docosahexaenoicacidacylatedastaxanthinestersexhibitsuperiorrenalprotectiveeffecttorecombinationofastaxanthinwithdhaviaalleviatingoxidativestresscoupledwithapoptosisinvancomycintreatedmicewithnephrotoxicity AT yumingwang docosahexaenoicacidacylatedastaxanthinestersexhibitsuperiorrenalprotectiveeffecttorecombinationofastaxanthinwithdhaviaalleviatingoxidativestresscoupledwithapoptosisinvancomycintreatedmicewithnephrotoxicity AT tiantianzhang docosahexaenoicacidacylatedastaxanthinestersexhibitsuperiorrenalprotectiveeffecttorecombinationofastaxanthinwithdhaviaalleviatingoxidativestresscoupledwithapoptosisinvancomycintreatedmicewithnephrotoxicity |
_version_ |
1716870317183336448 |