Natural anti-inflammatory terpenoids in Camellia japonica leaf and probable biosynthesis pathways of the metabolome
Abstract Background Metabolomics of Camellia japonica leaf has been studied to identify the terpenoids present in it and their interrelations regarding biosynthesis as most of their pathways are closely situated. Camellia japonica is famous for its anti-inflammatory activity in the field of medicine...
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2020-08-01
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Online Access: | http://link.springer.com/article/10.1186/s42269-020-00397-7 |
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doaj-14cb3916b3e2448db2d434e0ab60fb582020-11-25T03:54:03ZengSpringerOpenBulletin of the National Research Centre2522-83072020-08-0144111410.1186/s42269-020-00397-7Natural anti-inflammatory terpenoids in Camellia japonica leaf and probable biosynthesis pathways of the metabolomeSoumya Majumder0Arindam Ghosh1Malay Bhattacharya2Molecular Biology and Tissue Culture Laboratory, Department of Tea Science, University of North BengalMolecular Biology and Tissue Culture Laboratory, Department of Tea Science, University of North BengalMolecular Biology and Tissue Culture Laboratory, Department of Tea Science, University of North BengalAbstract Background Metabolomics of Camellia japonica leaf has been studied to identify the terpenoids present in it and their interrelations regarding biosynthesis as most of their pathways are closely situated. Camellia japonica is famous for its anti-inflammatory activity in the field of medicines and ethno-botany. In this research, we intended to study the metabolomics of Camellia japonica leaf by using gas chromatography-mass spectroscopy technique. Results A total of twenty-nine anti-inflammatory compounds, occupying 83.96% of total area, came out in the result. Most of the metabolites are terpenoids leading with triterpenoids like squalene, lupeol, and vitamin E. In this study, the candidate molecules responsible for anti-inflammatory activity were spotted out in the leaf extract and biosynthetic relation or interactions between those components were also established. Conclusion Finding novel anticancer and anti-inflammatory medicinal compounds like lupeol in a large amount in Camellia japonica leaf is the most remarkable outcome of this gas chromatography-mass spectroscopy analysis. Developing probable pathway for biosynthesis of methyl commate B is also noteworthy.http://link.springer.com/article/10.1186/s42269-020-00397-7Camellia japonicaMetabolomicsGC-MSAnti-inflammatory compoundsLupeol |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Soumya Majumder Arindam Ghosh Malay Bhattacharya |
spellingShingle |
Soumya Majumder Arindam Ghosh Malay Bhattacharya Natural anti-inflammatory terpenoids in Camellia japonica leaf and probable biosynthesis pathways of the metabolome Bulletin of the National Research Centre Camellia japonica Metabolomics GC-MS Anti-inflammatory compounds Lupeol |
author_facet |
Soumya Majumder Arindam Ghosh Malay Bhattacharya |
author_sort |
Soumya Majumder |
title |
Natural anti-inflammatory terpenoids in Camellia japonica leaf and probable biosynthesis pathways of the metabolome |
title_short |
Natural anti-inflammatory terpenoids in Camellia japonica leaf and probable biosynthesis pathways of the metabolome |
title_full |
Natural anti-inflammatory terpenoids in Camellia japonica leaf and probable biosynthesis pathways of the metabolome |
title_fullStr |
Natural anti-inflammatory terpenoids in Camellia japonica leaf and probable biosynthesis pathways of the metabolome |
title_full_unstemmed |
Natural anti-inflammatory terpenoids in Camellia japonica leaf and probable biosynthesis pathways of the metabolome |
title_sort |
natural anti-inflammatory terpenoids in camellia japonica leaf and probable biosynthesis pathways of the metabolome |
publisher |
SpringerOpen |
series |
Bulletin of the National Research Centre |
issn |
2522-8307 |
publishDate |
2020-08-01 |
description |
Abstract Background Metabolomics of Camellia japonica leaf has been studied to identify the terpenoids present in it and their interrelations regarding biosynthesis as most of their pathways are closely situated. Camellia japonica is famous for its anti-inflammatory activity in the field of medicines and ethno-botany. In this research, we intended to study the metabolomics of Camellia japonica leaf by using gas chromatography-mass spectroscopy technique. Results A total of twenty-nine anti-inflammatory compounds, occupying 83.96% of total area, came out in the result. Most of the metabolites are terpenoids leading with triterpenoids like squalene, lupeol, and vitamin E. In this study, the candidate molecules responsible for anti-inflammatory activity were spotted out in the leaf extract and biosynthetic relation or interactions between those components were also established. Conclusion Finding novel anticancer and anti-inflammatory medicinal compounds like lupeol in a large amount in Camellia japonica leaf is the most remarkable outcome of this gas chromatography-mass spectroscopy analysis. Developing probable pathway for biosynthesis of methyl commate B is also noteworthy. |
topic |
Camellia japonica Metabolomics GC-MS Anti-inflammatory compounds Lupeol |
url |
http://link.springer.com/article/10.1186/s42269-020-00397-7 |
work_keys_str_mv |
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