Altered Regional Cortical Brain Activity in Healthy Subjects After Sleep Deprivation: A Functional Magnetic Resonance Imaging Study

• Main Authors: Lingling Chen, Xueliang Qi, Jiyong Zheng
• Format: Article
• Language: English
• Published: Frontiers Media S.A. 2018-08-01
• Series: Frontiers in Neurology
• Subjects: sleep deprivation; receiver operating characteristic; area under the curve; amplitude of low frequency fluctuations; functional magnetic resonance imaging
• Online Access: https://www.frontiersin.org/article/10.3389/fneur.2018.00588/full

Objective: To investigate acute sleep deprivation (SD)-related regional brain activity changes and their relationships with behavioral performances.Methods: Twenty-two female subjects underwent an MRI scan and an attention network test at rested wakefulness (RW) status and after 24 h SD. The amplitude of low-frequency fluctuations (ALFF) was used to investigate SD-related regional brain activity changes. We used the receiver operating characteristic (ROC) curve to evaluate the ability of the ALFF differences in regional brain areas to distinguish the SD status from the RW status. We used Pearson correlations to evaluate the relationships between the ALFF differences in brain areas and the behavioral performances during the SD status.Results: Subjects at the SD status exhibited a lower accuracy rate and a longer reaction time relative to the RW status. Compared with RW, SD showed significant lower ALFF values in the right cerebellum anterior lobe, and higher ALFF areas in the bilateral inferior occipital gyrus, left thalamus, left insula, and bilateral postcentral gyrus. The area under the curve values of the specific ALFF differences in brain areas were (mean ± std, 0.851 ± 0.045; 0.805–0.93). Further, the ROC curve analysis demonstrated that the ALFF differences in those regional brain areas alone discriminated the SD status from the RW status with high degrees of sensitivities (82.16 ± 7.61%; 75–93.8%) and specificities (81.23 ± 11.39%; 62.5–93.7%). The accuracy rate showed negative correlations with the left inferior occipital gyrus, left thalamus, and left postcentral gyrus, and showed a positive correlation with the right cerebellum.Conclusions: The ALFF analysis is a potential indicator for detecting the excitation–inhibition imbalance of regional cortical activations disturbed by acute SD with high performances.