Gigantic GIST: A Case of the Largest Gastrointestinal Stromal Tumor Found to Date
Gastrointestinal stromal tumors are uncommon when compared to all gastrointestinal neoplasms but are the most common mesenchymal tumors of the gastrointestinal tract. The largest gastrointestinal stromal tumor ever recorded in literature weighed approximately 6.1 kg and measured 39 cm × 27 cm × 14 c...
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doaj-14d9d2d7941b40daa60200727b2d2fae2020-11-24T22:07:54ZengHindawi LimitedCase Reports in Surgery2090-69002090-69192018-01-01201810.1155/2018/61708616170861Gigantic GIST: A Case of the Largest Gastrointestinal Stromal Tumor Found to DateAbdalla Mohamed0Youssef Botros1Paul Hanna2Sang Lee3Walid Baddoura4Jamshed Zuberi5Tanuja Damani6Department of Medicine, St. Joseph’s University Medical Center, Paterson, NJ, USADivision of Gastroenterology and Hepatology, St. Joseph’s University Medical Center, Paterson, NJ, USADepartment of Surgery, St. Joseph’s University Medical Center, Paterson, NJ, USADepartment of Surgery, St. Joseph’s University Medical Center, Paterson, NJ, USADivision of Gastroenterology and Hepatology, St. Joseph’s University Medical Center, Paterson, NJ, USADepartment of Surgery, St. Joseph’s University Medical Center, Paterson, NJ, USADepartment of Surgery, St. Joseph’s University Medical Center, Paterson, NJ, USAGastrointestinal stromal tumors are uncommon when compared to all gastrointestinal neoplasms but are the most common mesenchymal tumors of the gastrointestinal tract. The largest gastrointestinal stromal tumor ever recorded in literature weighed approximately 6.1 kg and measured 39 cm × 27 cm × 14 cm. About two-thirds of GISTs are malignant. The tumor size, mitotic rate, cellularity, and nuclear pleomorphism are the most important parameters when considering prognosis and recurrence. The definitive treatment for these tumors is resection. In the year 2000, the first patient was treated with the tyrosine kinase inhibitor imatinib and since then, gastrointestinal stromal tumors with high-risk features have been treated successfully with tyrosine kinase inhibitors. We present the largest gastrointestinal stromal tumor recorded in medical literature measuring 42.0 cm × 31.0 cm × 23.0 cm in maximum dimensions and weighing in at approximately 18.5 kg in a 65-year-old African-American male who presented with increased abdominal distention. The mass was successfully excised, and the patient was treated with imatinib without local or distant recurrence 1.5 years postoperatively.http://dx.doi.org/10.1155/2018/6170861 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Abdalla Mohamed Youssef Botros Paul Hanna Sang Lee Walid Baddoura Jamshed Zuberi Tanuja Damani |
spellingShingle |
Abdalla Mohamed Youssef Botros Paul Hanna Sang Lee Walid Baddoura Jamshed Zuberi Tanuja Damani Gigantic GIST: A Case of the Largest Gastrointestinal Stromal Tumor Found to Date Case Reports in Surgery |
author_facet |
Abdalla Mohamed Youssef Botros Paul Hanna Sang Lee Walid Baddoura Jamshed Zuberi Tanuja Damani |
author_sort |
Abdalla Mohamed |
title |
Gigantic GIST: A Case of the Largest Gastrointestinal Stromal Tumor Found to Date |
title_short |
Gigantic GIST: A Case of the Largest Gastrointestinal Stromal Tumor Found to Date |
title_full |
Gigantic GIST: A Case of the Largest Gastrointestinal Stromal Tumor Found to Date |
title_fullStr |
Gigantic GIST: A Case of the Largest Gastrointestinal Stromal Tumor Found to Date |
title_full_unstemmed |
Gigantic GIST: A Case of the Largest Gastrointestinal Stromal Tumor Found to Date |
title_sort |
gigantic gist: a case of the largest gastrointestinal stromal tumor found to date |
publisher |
Hindawi Limited |
series |
Case Reports in Surgery |
issn |
2090-6900 2090-6919 |
publishDate |
2018-01-01 |
description |
Gastrointestinal stromal tumors are uncommon when compared to all gastrointestinal neoplasms but are the most common mesenchymal tumors of the gastrointestinal tract. The largest gastrointestinal stromal tumor ever recorded in literature weighed approximately 6.1 kg and measured 39 cm × 27 cm × 14 cm. About two-thirds of GISTs are malignant. The tumor size, mitotic rate, cellularity, and nuclear pleomorphism are the most important parameters when considering prognosis and recurrence. The definitive treatment for these tumors is resection. In the year 2000, the first patient was treated with the tyrosine kinase inhibitor imatinib and since then, gastrointestinal stromal tumors with high-risk features have been treated successfully with tyrosine kinase inhibitors. We present the largest gastrointestinal stromal tumor recorded in medical literature measuring 42.0 cm × 31.0 cm × 23.0 cm in maximum dimensions and weighing in at approximately 18.5 kg in a 65-year-old African-American male who presented with increased abdominal distention. The mass was successfully excised, and the patient was treated with imatinib without local or distant recurrence 1.5 years postoperatively. |
url |
http://dx.doi.org/10.1155/2018/6170861 |
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