TFF3 interacts with LINGO2 to regulate EGFR activation for protection against colitis and gastrointestinal helminths
TFF3 secretion by goblet cells regulates mucus viscosity and wound healing, but a receptor for TFF3 has not been identified. Here, the authors show that TFF3 binds LINGO2 to de-repress and enhance EGFR signaling that drives wound healing and immunity against helminths.
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Nature Publishing Group
2019-09-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-019-12315-1 |
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doaj-14dea147249543ad842b96b14c99cd1b2021-05-11T12:35:07ZengNature Publishing GroupNature Communications2041-17232019-09-0110111310.1038/s41467-019-12315-1TFF3 interacts with LINGO2 to regulate EGFR activation for protection against colitis and gastrointestinal helminthsNicole Maloney Belle0Yingbiao Ji1Karl Herbine2Yun Wei3JoonHyung Park4Kelly Zullo5Li-Yin Hung6Sriram Srivatsa7Tanner Young8Taylor Oniskey9Christopher Pastore10Wildaliz Nieves11Ma Somsouk12De’Broski R. Herbert13Department of Pathobiology, University of Pennsylvania School of Veterinary MedicineDepartment of Pathobiology, University of Pennsylvania School of Veterinary MedicineDepartment of Pathobiology, University of Pennsylvania School of Veterinary MedicineDivision of Experimental Medicine, University of California, San FranciscoDepartment of Pathobiology, University of Pennsylvania School of Veterinary MedicineDepartment of Pathobiology, University of Pennsylvania School of Veterinary MedicineDepartment of Pathobiology, University of Pennsylvania School of Veterinary MedicineDepartment of Pathobiology, University of Pennsylvania School of Veterinary MedicineDepartment of Pathobiology, University of Pennsylvania School of Veterinary MedicineDivision of Experimental Medicine, University of California, San FranciscoDepartment of Pathobiology, University of Pennsylvania School of Veterinary MedicineDivision of Gastroenterology at ZSFG, University of California, San FranciscoDivision of Gastroenterology at ZSFG, University of California, San FranciscoDepartment of Pathobiology, University of Pennsylvania School of Veterinary MedicineTFF3 secretion by goblet cells regulates mucus viscosity and wound healing, but a receptor for TFF3 has not been identified. Here, the authors show that TFF3 binds LINGO2 to de-repress and enhance EGFR signaling that drives wound healing and immunity against helminths.https://doi.org/10.1038/s41467-019-12315-1 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Nicole Maloney Belle Yingbiao Ji Karl Herbine Yun Wei JoonHyung Park Kelly Zullo Li-Yin Hung Sriram Srivatsa Tanner Young Taylor Oniskey Christopher Pastore Wildaliz Nieves Ma Somsouk De’Broski R. Herbert |
spellingShingle |
Nicole Maloney Belle Yingbiao Ji Karl Herbine Yun Wei JoonHyung Park Kelly Zullo Li-Yin Hung Sriram Srivatsa Tanner Young Taylor Oniskey Christopher Pastore Wildaliz Nieves Ma Somsouk De’Broski R. Herbert TFF3 interacts with LINGO2 to regulate EGFR activation for protection against colitis and gastrointestinal helminths Nature Communications |
author_facet |
Nicole Maloney Belle Yingbiao Ji Karl Herbine Yun Wei JoonHyung Park Kelly Zullo Li-Yin Hung Sriram Srivatsa Tanner Young Taylor Oniskey Christopher Pastore Wildaliz Nieves Ma Somsouk De’Broski R. Herbert |
author_sort |
Nicole Maloney Belle |
title |
TFF3 interacts with LINGO2 to regulate EGFR activation for protection against colitis and gastrointestinal helminths |
title_short |
TFF3 interacts with LINGO2 to regulate EGFR activation for protection against colitis and gastrointestinal helminths |
title_full |
TFF3 interacts with LINGO2 to regulate EGFR activation for protection against colitis and gastrointestinal helminths |
title_fullStr |
TFF3 interacts with LINGO2 to regulate EGFR activation for protection against colitis and gastrointestinal helminths |
title_full_unstemmed |
TFF3 interacts with LINGO2 to regulate EGFR activation for protection against colitis and gastrointestinal helminths |
title_sort |
tff3 interacts with lingo2 to regulate egfr activation for protection against colitis and gastrointestinal helminths |
publisher |
Nature Publishing Group |
series |
Nature Communications |
issn |
2041-1723 |
publishDate |
2019-09-01 |
description |
TFF3 secretion by goblet cells regulates mucus viscosity and wound healing, but a receptor for TFF3 has not been identified. Here, the authors show that TFF3 binds LINGO2 to de-repress and enhance EGFR signaling that drives wound healing and immunity against helminths. |
url |
https://doi.org/10.1038/s41467-019-12315-1 |
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