TFF3 interacts with LINGO2 to regulate EGFR activation for protection against colitis and gastrointestinal helminths

TFF3 interacts with LINGO2 to regulate EGFR activation for protection against colitis and gastrointestinal helminths

TFF3 secretion by goblet cells regulates mucus viscosity and wound healing, but a receptor for TFF3 has not been identified. Here, the authors show that TFF3 binds LINGO2 to de-repress and enhance EGFR signaling that drives wound healing and immunity against helminths.

Bibliographic Details
Main Authors: Nicole Maloney Belle, Yingbiao Ji, Karl Herbine, Yun Wei, JoonHyung Park, Kelly Zullo, Li-Yin Hung, Sriram Srivatsa, Tanner Young, Taylor Oniskey, Christopher Pastore, Wildaliz Nieves, Ma Somsouk, De’Broski R. Herbert
Format: Article
Language:English
Published: Nature Publishing Group 2019-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-12315-1
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spelling doaj-14dea147249543ad842b96b14c99cd1b2021-05-11T12:35:07ZengNature Publishing GroupNature Communications2041-17232019-09-0110111310.1038/s41467-019-12315-1TFF3 interacts with LINGO2 to regulate EGFR activation for protection against colitis and gastrointestinal helminthsNicole Maloney Belle0Yingbiao Ji1Karl Herbine2Yun Wei3JoonHyung Park4Kelly Zullo5Li-Yin Hung6Sriram Srivatsa7Tanner Young8Taylor Oniskey9Christopher Pastore10Wildaliz Nieves11Ma Somsouk12De’Broski R. Herbert13Department of Pathobiology, University of Pennsylvania School of Veterinary MedicineDepartment of Pathobiology, University of Pennsylvania School of Veterinary MedicineDepartment of Pathobiology, University of Pennsylvania School of Veterinary MedicineDivision of Experimental Medicine, University of California, San FranciscoDepartment of Pathobiology, University of Pennsylvania School of Veterinary MedicineDepartment of Pathobiology, University of Pennsylvania School of Veterinary MedicineDepartment of Pathobiology, University of Pennsylvania School of Veterinary MedicineDepartment of Pathobiology, University of Pennsylvania School of Veterinary MedicineDepartment of Pathobiology, University of Pennsylvania School of Veterinary MedicineDivision of Experimental Medicine, University of California, San FranciscoDepartment of Pathobiology, University of Pennsylvania School of Veterinary MedicineDivision of Gastroenterology at ZSFG, University of California, San FranciscoDivision of Gastroenterology at ZSFG, University of California, San FranciscoDepartment of Pathobiology, University of Pennsylvania School of Veterinary MedicineTFF3 secretion by goblet cells regulates mucus viscosity and wound healing, but a receptor for TFF3 has not been identified. Here, the authors show that TFF3 binds LINGO2 to de-repress and enhance EGFR signaling that drives wound healing and immunity against helminths.https://doi.org/10.1038/s41467-019-12315-1
collection DOAJ
language English
format Article
sources DOAJ
author Nicole Maloney Belle
Yingbiao Ji
Karl Herbine
Yun Wei
JoonHyung Park
Kelly Zullo
Li-Yin Hung
Sriram Srivatsa
Tanner Young
Taylor Oniskey
Christopher Pastore
Wildaliz Nieves
Ma Somsouk
De’Broski R. Herbert
spellingShingle Nicole Maloney Belle
Yingbiao Ji
Karl Herbine
Yun Wei
JoonHyung Park
Kelly Zullo
Li-Yin Hung
Sriram Srivatsa
Tanner Young
Taylor Oniskey
Christopher Pastore
Wildaliz Nieves
Ma Somsouk
De’Broski R. Herbert
TFF3 interacts with LINGO2 to regulate EGFR activation for protection against colitis and gastrointestinal helminths
Nature Communications
author_facet Nicole Maloney Belle
Yingbiao Ji
Karl Herbine
Yun Wei
JoonHyung Park
Kelly Zullo
Li-Yin Hung
Sriram Srivatsa
Tanner Young
Taylor Oniskey
Christopher Pastore
Wildaliz Nieves
Ma Somsouk
De’Broski R. Herbert
author_sort Nicole Maloney Belle
title TFF3 interacts with LINGO2 to regulate EGFR activation for protection against colitis and gastrointestinal helminths
title_short TFF3 interacts with LINGO2 to regulate EGFR activation for protection against colitis and gastrointestinal helminths
title_full TFF3 interacts with LINGO2 to regulate EGFR activation for protection against colitis and gastrointestinal helminths
title_fullStr TFF3 interacts with LINGO2 to regulate EGFR activation for protection against colitis and gastrointestinal helminths
title_full_unstemmed TFF3 interacts with LINGO2 to regulate EGFR activation for protection against colitis and gastrointestinal helminths
title_sort tff3 interacts with lingo2 to regulate egfr activation for protection against colitis and gastrointestinal helminths
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2019-09-01
description TFF3 secretion by goblet cells regulates mucus viscosity and wound healing, but a receptor for TFF3 has not been identified. Here, the authors show that TFF3 binds LINGO2 to de-repress and enhance EGFR signaling that drives wound healing and immunity against helminths.
url https://doi.org/10.1038/s41467-019-12315-1
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