TFF3 interacts with LINGO2 to regulate EGFR activation for protection against colitis and gastrointestinal helminths
TFF3 secretion by goblet cells regulates mucus viscosity and wound healing, but a receptor for TFF3 has not been identified. Here, the authors show that TFF3 binds LINGO2 to de-repress and enhance EGFR signaling that drives wound healing and immunity against helminths.
Main Authors: | Nicole Maloney Belle, Yingbiao Ji, Karl Herbine, Yun Wei, JoonHyung Park, Kelly Zullo, Li-Yin Hung, Sriram Srivatsa, Tanner Young, Taylor Oniskey, Christopher Pastore, Wildaliz Nieves, Ma Somsouk, De’Broski R. Herbert |
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Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2019-09-01
|
Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-019-12315-1 |
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